Medicine Information

D-Fix

Name: D-Fix
Brand: D-Fix
Rating: 4.5 (117 reviews)

Capsule400 mgAntibiotics (Cephalosporins)ATC: J01DD08

Generic Name

Cefixime

Manufacturer

ACI Pharmaceuticals

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
d fix 400 mg capsule	৳ 50.00	৳ 200.00

Description

Overview of the medicine

Cefixime is a broad-spectrum cephalosporin antibiotic used to treat a variety of bacterial infections.

Uses & Indications

Uncomplicated Urinary Tract Infections (UTIs)

Otitis Media

Pharyngitis and Tonsillitis

Acute Bronchitis and Acute Exacerbations of Chronic Bronchitis

Uncomplicated Gonorrhea

Pneumonia

Dosage

Adults

The usual adult dose is 400 mg once daily or 200 mg every 12 hours. For uncomplicated gonorrhea, a single dose of 400 mg is recommended.

Elderly

No specific dosage adjustment is necessary for elderly patients unless there is severe renal impairment.

Renal_impairment

In patients with creatinine clearance less than 60 mL/min, the dose should be reduced. For creatinine clearance between 21-60 mL/min, 300 mg daily; for less than 20 mL/min, 100-200 mg daily.

How to Take

D-Fix 400 mg capsule can be taken with or without food. It should be swallowed whole with a glass of water. It is important to complete the full course of treatment as prescribed by the doctor, even if symptoms improve.

Mechanism of Action

Cefixime exerts its bactericidal effect by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, preventing the final transpeptidation step of peptidoglycan synthesis.

Pharmacokinetics

Onset

Antibacterial effect typically observed within 2-4 hours.

Excretion

Primarily renal excretion (approximately 50% of absorbed dose via urine) and biliary excretion (about 10% via bile).

Half life

The plasma half-life is typically 3-4 hours, which allows for once or twice daily dosing.

Absorption

Oral absorption of cefixime is about 30-50% and is relatively slow, reaching peak plasma concentrations 2-8 hours after administration.

Metabolism

Cefixime is not extensively metabolized; about 50% of an absorbed dose is excreted unchanged in the urine.

Side Effects

Contraindications

Known hypersensitivity to cefixime or other cephalosporin antibiotics.
History of serious hypersensitivity reactions to penicillin or other beta-lactam antibiotics.

Drug Interactions

Probenecid

Increases cefixime plasma concentrations by inhibiting renal excretion.

Carbamazepine

Concomitant administration may increase carbamazepine plasma concentrations.

Oral Contraceptives

May decrease the effectiveness of oral contraceptives, requiring additional birth control methods.

Warfarin and other anticoagulants

May increase prothrombin time with or without bleeding. Close monitoring of INR is recommended.

Storage

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Overdose

In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Symptomatic and supportive treatment is recommended.

Pregnancy & Lactation

Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Cefixime is excreted in small amounts in human milk; use with caution in nursing mothers.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 x 7 capsules (blister pack)1 x 10 capsules (blister pack)

Shelf Life

24 to 36 months from the date of manufacture, specific to manufacturer.

Availability

Pharmacies, hospitals, clinics

Approval Status

Approved by regulatory authorities

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Ongoing clinical trials focus on cefixime's efficacy against emerging resistant bacterial strains and in specific patient populations.

Lab Monitoring

Periodic assessment of renal and hepatic function may be advisable during prolonged therapy.
Monitor INR for patients on warfarin or other anticoagulants.

Doctor Notes

Counsel patients on the importance of completing the full antibiotic course to prevent resistance.
Be mindful of potential drug interactions, especially with anticoagulants.
Consider dose adjustment in patients with significant renal impairment.

Patient Guidelines

Take the medicine exactly as prescribed by your doctor.
Complete the entire course of treatment, even if you feel better, to prevent recurrence and development of antibiotic resistance.
Do not share this medicine with others.
Report any unusual or severe side effects to your doctor immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

D-Fix may cause dizziness in some individuals. Patients should be cautioned about operating machinery or driving until they know how they react to the medication.