Medicine Information

D-Rise

Name: D-Rise
Brand: D-Rise
Rating: 4.5 (117 reviews)

Capsule40000 IUVitamin D preparationsATC: A11CC05

Generic Name

Cholecalciferol (Vitamin D3)

Manufacturer

Utopian Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
d rise 40000 iu capsule	৳ 35.00	৳ 350.00

Description

Overview of the medicine

D-Rise 40000 IU Capsule contains Cholecalciferol (Vitamin D3), which is essential for calcium absorption, bone health, and immune function. It is used to treat and prevent Vitamin D deficiency and associated conditions.

Uses & Indications

Treatment and prevention of Vitamin D deficiency

Osteomalacia

Rickets

As an adjunct to specific therapy for osteoporosis

Dosage

Adults

For severe deficiency: 40,000 IU once weekly for 7 weeks, followed by maintenance. For moderate deficiency: 40,000 IU once every 2-4 weeks or as directed by physician.

Elderly

Same as adult dosage, but caution with concomitant medication and renal function.

Renal_impairment

Use with caution. Monitoring of calcium and phosphate levels is crucial. Specific dosage adjustment may be required.

How to Take

Oral. The capsule should be swallowed whole with water, preferably with a main meal to enhance absorption.

Mechanism of Action

Cholecalciferol is metabolized in the liver to calcifediol (25-hydroxyvitamin D3) and then in the kidneys to calcitriol (1,25-dihydroxyvitamin D3), the active form of Vitamin D. Calcitriol regulates calcium and phosphate homeostasis by promoting their absorption from the gut, reabsorption in the kidneys, and mobilization from bone.

Pharmacokinetics

Onset

Several hours to days for biological effects to become apparent, full effect within weeks.

Excretion

Mainly excreted in bile and feces, with a small amount excreted in urine.

Half life

Circulating 25(OH)D3 has a half-life of 2-3 weeks, while the active 1,25(OH)2D3 has a half-life of 4-6 hours.

Absorption

Well absorbed from the small intestine, especially when taken with fatty meals.

Metabolism

Primarily hydroxylated in the liver to 25-hydroxyvitamin D (calcifediol), then in the kidneys to 1,25-dihydroxyvitamin D (calcitriol).

Side Effects

Contraindications

Hypercalcaemia (high calcium levels)
Hypervitaminosis D (Vitamin D toxicity)
Nephrolithiasis (kidney stones) or nephrocalcinosis
Hypersensitivity to cholecalciferol or any excipients

Drug Interactions

Glucocorticoids

May decrease the effects of Vitamin D.

Thiazide diuretics

May increase risk of hypercalcaemia by reducing urinary calcium excretion.

Cardiac glycosides (e.g., Digoxin)

Increased risk of arrhythmias if hypercalcaemia occurs.

Anticonvulsants (e.g., Phenytoin, Barbiturates)

May reduce Vitamin D levels by accelerating its metabolism.

Storage

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Overdose

Symptoms include hypercalcaemia, nausea, vomiting, constipation, anorexia, polyuria, polydipsia, weakness, headache, and in severe cases, renal impairment, cardiac arrhythmias, and coma. Treatment involves stopping Vitamin D, hydration, and managing hypercalcaemia.

Pregnancy & Lactation

Generally considered safe at recommended daily allowances. High doses should be used with caution and only if clearly needed, under medical supervision, due to potential risk of hypercalcaemia in the mother and fetus.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules30 capsules

Shelf Life

Typically 24-36 months from manufacturing date.

Availability

Pharmacies, drugstores

Approval Status

Approved by regulatory authorities worldwide (e.g., FDA, EMA, DGDA)

Patent Status

Generic

Clinical Trials

Extensive clinical data supports the efficacy of Vitamin D in treating and preventing deficiency. Ongoing research explores its role in various other health conditions.

Lab Monitoring

Serum calcium levels
Serum phosphate levels
Serum 25(OH)D levels (to monitor Vitamin D status)
Renal function (e.g., creatinine)

Doctor Notes

Advise patients on dietary sources of Vitamin D and safe sun exposure.
Emphasize the importance of adherence to prescribed dosage and regular follow-up for monitoring serum levels.
Consider co-administering calcium if dietary intake is insufficient.

Patient Guidelines

Take as directed by your doctor.
Do not exceed the recommended dose.
Take with food to improve absorption.
Report any symptoms of hypercalcaemia immediately (e.g., severe nausea, vomiting, excessive thirst, frequent urination).

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

D-Rise 40000 IU Capsule is not known to affect the ability to drive or operate machinery.

Lifestyle Advice

Maintain a balanced diet.
Engage in regular outdoor activities for natural Vitamin D synthesis from sunlight.
Consult your doctor about calcium intake if also taking Vitamin D supplements.