Medicine Information

denixil-rapid

Name: denixil-rapid
Brand: denixil-rapid
Rating: 4.5 (117 reviews)

Tablet0.5 mgAnxiolytic, Sedative-Hypnotic (hypothetical)ATC: N05BA (hypothetical)

Generic Name

Denixil 0.5 mg Tablet

Manufacturer

Hypothetical Pharma Co.

Country

Bangladesh (hypothetical)

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
denixil rapid 05 mg tablet	৳ 7.00	৳ 70.00

Description

Overview of the medicine

Denixil-Rapid 0.5 mg Tablet is a fast-acting anxiolytic medication used for the short-term management of anxiety disorders and insomnia. It belongs to a class of drugs that enhance the effects of gamma-aminobutyric acid (GABA) in the brain, leading to a calming effect.

Uses & Indications

Short-term management of generalized anxiety disorder

Insomnia (difficulty falling asleep or staying asleep)

Panic attacks with or without agoraphobia

Dosage

Adults

Initial dose 0.25 mg to 0.5 mg orally, 2-3 times daily as needed. Max 4 mg/day.

Elderly

Initial dose 0.25 mg orally, 1-2 times daily. Titrate cautiously.

Renal_impairment

No specific dose adjustment required for mild to moderate impairment; use with caution in severe impairment.

How to Take

Take orally with or without food. Do not crush, chew, or break the tablet. Swallow whole.

Mechanism of Action

Denixil binds to specific sites on GABA-A receptors in the brain, increasing the frequency of chloride channel opening. This enhances the inhibitory effects of GABA, leading to CNS depression, anxiolysis, sedation, and muscle relaxation.

Pharmacokinetics

Onset

15-30 minutes

Excretion

Mainly excreted in urine as metabolites, with a small amount excreted in feces.

Half life

Approximately 6-8 hours (intermediate-acting)

Absorption

Rapidly and completely absorbed from the gastrointestinal tract, achieving peak plasma concentrations within 30-60 minutes.

Metabolism

Primarily metabolized in the liver via oxidative pathways, producing active and inactive metabolites.

Side Effects

Contraindications

Known hypersensitivity to Denixil or other benzodiazepines
Acute narrow-angle glaucoma
Severe respiratory insufficiency
Severe hepatic insufficiency
Myasthenia gravis

Drug Interactions

Opioids

Increased risk of severe respiratory depression and sedation.

Alcohol/CNS Depressants

Potentiation of sedative effects, increased risk of respiratory depression.

CYP3A4 Inducers (e.g., rifampin, phenytoin)

May decrease Denixil plasma concentrations, reducing efficacy.

CYP3A4 Inhibitors (e.g., ketoconazole, erythromycin)

May increase Denixil plasma concentrations, leading to enhanced effects.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms include drowsiness, confusion, ataxia, diminished reflexes, and coma. Management involves supportive care, maintaining airway, and potentially flumazenil (benzodiazepine receptor antagonist) for severe cases.

Pregnancy & Lactation

Pregnancy Category D. May cause fetal harm. Not recommended during breastfeeding as it may pass into breast milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets (1x10)30 tablets (3x10)

Shelf Life

24 months from manufacturing date

Availability

Pharmacies (hypothetical)

Approval Status

Not applicable (hypothetical drug)

Patent Status

Unknown (hypothetical)

Clinical Trials

As a hypothetical drug, specific clinical trial information is not available. Clinical trials would typically assess efficacy and safety in anxiety and insomnia.

Lab Monitoring

Liver function tests (especially with prolonged use or hepatic impairment).
Renal function tests (in patients with severe renal impairment).

Doctor Notes

Prescribe for the shortest duration possible to minimize risk of dependence.
Counsel patients on risks of sedation, especially when combined with alcohol or other CNS depressants.
Consider alternative non-pharmacological therapies for anxiety and insomnia.

Patient Guidelines

Do not stop taking Denixil-Rapid abruptly, as this may lead to withdrawal symptoms. Consult your doctor for gradual dose reduction.
Avoid operating heavy machinery or driving until you know how this medicine affects you.
Inform your doctor about all other medications, including over-the-counter drugs and herbal supplements.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and resume your regular schedule. Do not double the dose.

Driving Precautions

This medicine may cause drowsiness, dizziness, or blurred vision. Do not drive or operate machinery until you are certain you can perform such activities safely.

Lifestyle Advice

Practice good sleep hygiene, such as maintaining a regular sleep schedule and avoiding caffeine before bed.
Incorporate stress-reduction techniques like meditation or yoga.