Medicine Information

Depresil

Name: Depresil
Brand: Depresil
Rating: 4.5 (117 reviews)

Tablet0.5 mgAntidepressantATC: N06AB10

Generic Name

Serotalin Tartrate

Manufacturer

PharmaCorp Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
depresil 05 mg tablet	৳ 4.50	৳ 45.00

Description

Overview of the medicine

Depresil 0.5 mg tablet is an antidepressant medication used to treat major depressive disorder, generalized anxiety disorder, and panic disorder. It helps restore the balance of certain natural substances (neurotransmitters) in the brain.

Uses & Indications

Major Depressive Disorder (MDD)

Generalized Anxiety Disorder (GAD)

Panic Disorder (PD) with or without agoraphobia

Dosage

Adults

Initial dose 0.5 mg once daily, may be increased to a maximum of 2 mg daily based on clinical response and tolerability. Maintenance dose typically 0.5-1 mg daily.

Elderly

A lower initial dose of 0.25 mg once daily may be considered, with careful titration up to a maximum of 1 mg daily.

Renal_impairment

No specific dose adjustment is typically required for mild to moderate renal impairment. For severe impairment (CrCl <30 mL/min), caution is advised, and a lower dose may be necessary.

How to Take

Depresil tablets should be taken orally once daily, with or without food. It is recommended to take the tablet at the same time each day.

Mechanism of Action

Depresil works by selectively inhibiting the reuptake of serotonin in the brain's neurons. This increases the concentration of serotonin in the synaptic cleft, thereby enhancing serotonergic neurotransmission and improving mood and anxiety symptoms.

Pharmacokinetics

Onset

Initial therapeutic effects may be observed within 1-2 weeks, full effect in 4-6 weeks.

Excretion

Excreted mainly via urine as metabolites, with a small portion excreted in feces.

Half life

Approximately 20-30 hours, allowing for once-daily dosing.

Absorption

Well absorbed orally, with peak plasma concentrations achieved within 2-4 hours.

Metabolism

Primarily metabolized in the liver by cytochrome P450 enzymes, mainly CYP2C19 and CYP3A4.

Side Effects

Contraindications

Hypersensitivity to Serotalin Tartrate or any component of the formulation.
Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing MAOI therapy.
Severe hepatic impairment.

Drug Interactions

MAOIs

Concurrent use is contraindicated due to risk of serotonin syndrome.

NSAIDs

Increased risk of gastrointestinal bleeding.

Warfarin

May increase anticoagulant effect, monitor INR.

Tricyclic Antidepressants (TCAs)

May increase plasma levels of TCAs, requiring dose adjustment.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose may include drowsiness, nausea, vomiting, tachycardia, tremor, and dizziness. Severe overdose can lead to serotonin syndrome, seizures, and coma. Treatment is symptomatic and supportive. Maintain an open airway, monitor cardiac and vital signs, and administer activated charcoal if ingestion is recent.

Pregnancy & Lactation

Pregnancy Category C. Depresil should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in human milk; therefore, caution should be exercised when administered to a nursing woman.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per strip30 tablets per box

Shelf Life

36 months from the date of manufacture

Availability

Available in pharmacies nationwide

Approval Status

Approved

Patent Status

Patented

Clinical Trials

Depresil underwent Phase I, II, and III clinical trials demonstrating its efficacy and safety for approved indications. Post-marketing surveillance is ongoing.

Lab Monitoring

No routine lab monitoring is required.
Monitor serum sodium levels in patients at risk of hyponatremia.
Liver function tests may be considered in patients with pre-existing hepatic impairment.

Doctor Notes

Emphasize the importance of gradual dose tapering when discontinuing treatment to minimize withdrawal symptoms.
Educate patients on the delayed onset of full therapeutic effects and the need for consistent daily dosing.
Monitor for emergent suicidal ideation, especially in young patients, and serotonin syndrome when co-administered with other serotonergic agents.

Patient Guidelines

Take Depresil exactly as prescribed by your doctor.
Do not stop taking the medicine abruptly, as this can lead to withdrawal symptoms. Gradual tapering is necessary.
Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Depresil may cause drowsiness, dizziness, or blurred vision. Patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that Depresil does not adversely affect their ability to engage in such activities.

Lifestyle Advice

Avoid alcohol consumption while taking Depresil, as it may worsen side effects.
Maintain a healthy lifestyle with regular exercise and a balanced diet to support overall mental well-being.