Medicine Information

Deprolin-G

Name: Deprolin-G
Brand: Deprolin-G
Rating: 4.5 (117 reviews)

Syrup200 mg / 5 mlAnticonvulsants; Neuropathic Pain AgentsATC: N03AX12

Generic Name

Gabapentin

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
deprolin g 200 mg syrup	৳ 85.00	N/A

Description

Overview of the medicine

Deprolin-G 200 mg Syrup contains Gabapentin, an antiepileptic drug also used to treat neuropathic pain. It is an oral solution formulated for ease of administration, especially in patients who have difficulty swallowing tablets.

Uses & Indications

Adjunctive therapy in the treatment of partial seizures with and without secondary generalization in adults and children 3 years and older.

Management of postherpetic neuralgia in adults.

Neuropathic pain (e.g., diabetic neuropathy, post-stroke pain).

Dosage

Adults

Starting dose for neuropathic pain is typically 300 mg once daily on day 1, 300 mg twice daily on day 2, and 300 mg three times daily on day 3, then titrated up to a maximum of 1800-3600 mg/day in three divided doses. For seizures, starting dose is 300 mg three times daily, adjusted based on response up to 3600 mg/day.

Elderly

Dosage should be adjusted based on renal function, as Gabapentin is renally eliminated. Start with a lower dose and titrate cautiously.

Renal_impairment

Dosage must be reduced significantly based on creatinine clearance. For CrCl <30 mL/min, maximum daily dose may be 300 mg every other day or 300 mg daily for CrCl 15-29 mL/min.

How to Take

Deprolin-G syrup can be taken with or without food. Measure the dose accurately using the provided measuring device. Do not stop taking the medicine suddenly without consulting your doctor.

Mechanism of Action

Gabapentin's exact mechanism of action is not fully understood but it is believed to involve binding to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, which reduces the release of excitatory neurotransmitters. This action contributes to its anticonvulsant and analgesic effects.

Pharmacokinetics

Onset

Varies depending on indication, typically within hours for pain relief, longer for seizure control to reach steady state.

Excretion

Excreted unchanged by the kidneys. Renal clearance is directly proportional to creatinine clearance.

Half life

Approximately 5 to 7 hours in adults with normal renal function.

Absorption

Rapidly absorbed after oral administration, but absorption is saturable, meaning bioavailability decreases with increasing dose.

Metabolism

Not significantly metabolized in humans; does not induce hepatic enzymes.

Side Effects

Contraindications

Hypersensitivity to Gabapentin or any component of the formulation.
Acute pancreatitis (rare, but reported).

Drug Interactions

Alcohol

May enhance CNS depressant effects of Gabapentin.

Antacids

May decrease Gabapentin bioavailability; separate administration by at least 2 hours.

Opioids (e.g., Morphine)

May increase Gabapentin concentrations and enhance CNS depression. Monitor for increased sedation and respiratory depression.

Storage

Store below 30°C in a dry place, away from direct light. Keep out of reach of children.

Overdose

Symptoms of overdose include dizziness, double vision, slurred speech, drowsiness, lethargy, and mild diarrhea. Management is primarily supportive care; hemodialysis can be used in severe renal impairment or life-threatening overdose.

Pregnancy & Lactation

Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Gabapentin is excreted in human milk; use with caution in nursing mothers.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

100 ml syrup bottle200 ml syrup bottle

Shelf Life

Typically 24 months from manufacturing date when stored correctly.

Availability

Pharmacies, hospitals

Approval Status

Approved

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have demonstrated Gabapentin's efficacy in managing partial seizures and neuropathic pain. Post-marketing surveillance continues to monitor safety and efficacy.

Lab Monitoring

Renal function (creatinine clearance) in elderly or renally impaired patients.
Monitor for signs of CNS depression and behavioral changes.

Doctor Notes

Advise patients on the importance of gradual titration and discontinuation to minimize adverse effects.
Counsel patients about the risk of CNS depression, especially with concomitant use of other depressants or alcohol.
Emphasize reporting any mood changes or suicidal ideation.

Patient Guidelines

Take this medicine exactly as prescribed by your doctor.
Do not stop taking Gabapentin suddenly, as it may increase seizure frequency.
Report any new or worsening depression, suicidal thoughts, or unusual changes in mood or behavior to your doctor immediately.
Avoid driving or operating heavy machinery until you know how this medicine affects you, as it may cause dizziness or drowsiness.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Gabapentin can cause dizziness, drowsiness, and impaired coordination. Patients should be warned not to drive or operate hazardous machinery until they are reasonably certain that Gabapentin does not adversely affect their ability to engage in such activities.