Medicine Information

Desofast

Name: Desofast
Brand: Desofast
Rating: 4.5 (117 reviews)

Syrup / Oral Solution2.5 mg/5 mLAntihistaminesATC: R06AX27

Generic Name

Desloratadine 2.5 mg/5 mL Syrup

Manufacturer

XYZ Pharma Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
desofast 25 mg syrup	৳ 24.00	N/A

Description

Overview of the medicine

Desofast 2.5 mg/5 mL Syrup is an antihistamine used to relieve symptoms of allergic rhinitis and chronic idiopathic urticaria. It is a non-drowsy formulation.

Uses & Indications

Relief of symptoms associated with seasonal allergic rhinitis

Relief of symptoms associated with perennial allergic rhinitis

Relief of symptoms associated with chronic idiopathic urticaria

Dosage

Adults

5 mg (10 mL syrup) once daily.

Elderly

No specific dose adjustment is generally required, but caution is advised in patients with renal or hepatic impairment.

Renal_impairment

For patients with renal impairment, the starting dose should be 5 mg (10 mL syrup) every other day. Consult a physician.

Pediatric_1_5_years

1.25 mg (2.5 mL syrup) once daily.

Pediatric_6_11_years

2.5 mg (5 mL syrup) once daily.

Pediatric_6_11_months

1.25 mg (2.5 mL syrup) once daily.

How to Take

Take orally, with or without food. Use an accurate measuring device (e.g., spoon or syringe) provided with the syrup to ensure correct dosage.

Mechanism of Action

Desloratadine is a selective peripheral H1-receptor antagonist. It inhibits the release of histamine from mast cells and basophils, and also inhibits the expression of adhesion molecules and pro-inflammatory cytokines, thus reducing allergic symptoms.

Pharmacokinetics

Onset

Onset of action typically occurs within 1 hour.

Excretion

Approximately 87% of the desloratadine dose is excreted in urine and feces as metabolites.

Half life

Mean terminal elimination half-life is approximately 27 hours.

Absorption

Rapidly absorbed after oral administration, detectable in plasma within 30 minutes. Peak plasma concentrations (Cmax) are reached approximately 3 hours after dosing.

Metabolism

Extensively metabolized to an active metabolite, 3-hydroxydesloratadine. Metabolism is primarily by hydroxylation, followed by glucuronidation.

Side Effects

Contraindications

Hypersensitivity to desloratadine, loratadine, or any component of the formulation.
Severe hepatic impairment.

Drug Interactions

Cimetidine

Increases plasma concentration of desloratadine, but no clinically significant adverse effects observed.

Erythromycin

Increases plasma concentration of desloratadine, but no clinically significant adverse effects observed.

Ketoconazole

Increases plasma concentration of desloratadine, but no clinically significant adverse effects observed.

Storage

Store below 30°C. Protect from light and moisture. Do not freeze.

Overdose

Symptoms of overdose may include somnolence, increased heart rate, and headache. In the event of an overdose, symptomatic and supportive treatment is recommended. Desloratadine is not eliminated by hemodialysis.

Pregnancy & Lactation

Pregnancy Category C. Use in pregnancy only if potential benefit justifies the potential risk to the fetus. Desloratadine is excreted in breast milk; therefore, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

30 mL syrup bottle60 mL syrup bottle100 mL syrup bottle

Shelf Life

24 months from manufacturing date.

Availability

Available in pharmacies nationwide

Approval Status

Approved by DGDA (Bangladesh)

Patent Status

Generic available, original patent expired

Clinical Trials

Desloratadine has undergone extensive clinical trials demonstrating its efficacy and safety in treating allergic rhinitis and chronic idiopathic urticaria in adults and pediatric patients.

Lab Monitoring

Routine laboratory monitoring is generally not required during desloratadine therapy.

Doctor Notes

Counsel parents on accurate dosing for pediatric patients using the provided measuring device.
Consider renal/hepatic function when prescribing to elderly patients or those with impaired function.

Patient Guidelines

Do not exceed the recommended dose.
If symptoms do not improve within a few days or worsen, consult your doctor.
Keep out of reach of children.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Desloratadine is generally non-drowsy. However, individuals may react differently. Exercise caution when driving or operating machinery until you know how this medication affects you.