Medicine Information

Destin

Name: Destin
Brand: Destin
Rating: 4.5 (117 reviews)

Syrup2.5 mg/5 mlAntihistamine (Second Generation)ATC: R06AX27

Generic Name

Desloratadine

Manufacturer

XYZ Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
destin 25 mg syrup	৳ 28.00	N/A

Description

Overview of the medicine

Destin 2.5 mg/5 ml Syrup contains Desloratadine, a non-sedating antihistamine used to relieve symptoms associated with allergic rhinitis (including seasonal and perennial) and chronic idiopathic urticaria. It helps to alleviate sneezing, runny nose, itchy nose or eyes, congestion, and skin rash/hives.

Uses & Indications

Relief of symptoms associated with seasonal allergic rhinitis

Relief of symptoms associated with perennial allergic rhinitis

Relief of symptoms associated with chronic idiopathic urticaria (hives)

Dosage

Adults

5 mg (10 ml) once daily.

Elderly

Usually no dosage adjustment required; monitor renal function.

Renal_impairment

Consider lower starting dose (e.g., 5 mg every other day) in severe renal impairment.

How to Take

For oral administration. Can be taken with or without food.

Mechanism of Action

Desloratadine is a long-acting tricyclic histamine antagonist with selective H1-receptor antagonist activity. It prevents histamine from binding to H1 receptors, thereby inhibiting the inflammatory response and symptoms of allergy. It also has anti-inflammatory properties.

Pharmacokinetics

Onset

Within 30-60 minutes

Excretion

Excreted primarily via urine and feces as metabolites.

Half life

Approximately 27 hours

Absorption

Rapidly absorbed from the gastrointestinal tract; food does not affect absorption.

Metabolism

Extensively metabolized to 3-hydroxydesloratadine (an active metabolite) via hydroxylation, followed by glucuronidation.

Side Effects

Contraindications

Hypersensitivity to Desloratadine, Loratadine, or any component of the formulation.
Patients with severe kidney or liver disease (use with caution).

Drug Interactions

Erythromycin

May increase plasma concentrations of desloratadine.

Ketoconazole

May increase plasma concentrations of desloratadine.

Storage

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Overdose

Symptoms include somnolence, increased heart rate, and headache. Treatment is symptomatic and supportive; no specific antidote.

Pregnancy & Lactation

Pregnancy: Limited data, use only if clearly needed. Lactation: Desloratadine is excreted in breast milk, use with caution.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

60 ml syrup100 ml syrup

Shelf Life

24-36 months from manufacturing date, check expiry date on packaging.

Availability

Pharmacies, hospitals, clinics

Approval Status

Approved by regulatory authorities

Patent Status

Patent expired, generic versions available

Clinical Trials

Desloratadine has undergone extensive clinical trials demonstrating its efficacy and safety in treating allergic rhinitis and chronic idiopathic urticaria across various patient populations.

Lab Monitoring

No routine lab monitoring required. In patients with renal or hepatic impairment, liver and kidney function tests may be considered.

Doctor Notes

Advise patients regarding the non-sedating nature, but counsel about individual variability.
Emphasize consistent daily dosing for optimal effect.
Rule out other conditions mimicking allergic symptoms.

Patient Guidelines

Take exactly as prescribed by your doctor.
Do not exceed the recommended dose.
Inform your doctor about any existing medical conditions or other medications you are taking.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.

Driving Precautions

Generally considered non-sedating, but individual responses vary. Exercise caution when driving or operating machinery until you know how this medicine affects you.