Medicine Information

Dexagen-L

Name: Dexagen-L
Brand: Dexagen-L
Rating: 4.5 (117 reviews)

Eye DropDexamethasone 0.1% + Levofloxacin 0.5%Corticosteroid & Anti-infectiveATC: S01CA01

Generic Name

Dexamethasone + Levofloxacin

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
dexagen l 01 05 eye drop	৳ 150.00	N/A

Description

Overview of the medicine

Dexagen-L eye drop is a combination medication containing Dexamethasone, a corticosteroid, and Levofloxacin, a fluoroquinolone antibiotic. It is used to treat inflammatory conditions of the eye where there is a risk of bacterial infection or an existing bacterial infection.

Uses & Indications

Bacterial conjunctivitis with inflammation

Post-operative ocular inflammation and infection prophylaxis

Keratitis and other superficial ocular infections susceptible to Levofloxacin where corticosteroid is indicated

Dosage

Adults

1-2 drops in the affected eye(s) 4 times daily, or as directed by the physician. Dosage may be tapered as symptoms improve.

Elderly

No specific dosage adjustment required, but use with caution due to potential for systemic side effects with prolonged use.

Renal_impairment

No specific dosage adjustment required for topical ophthalmic use.

How to Take

For ophthalmic use only. Tilt head back, pull down the lower eyelid to form a pouch, instill the drop(s) into the pouch. Close eye gently and apply pressure to the inner corner of the eye for 1-2 minutes to prevent systemic absorption. Do not touch the dropper tip to any surface.

Mechanism of Action

Dexamethasone reduces inflammation by inhibiting the release of inflammatory mediators and suppressing immune response. Levofloxacin kills bacteria by inhibiting DNA gyrase and topoisomerase IV, essential enzymes for bacterial DNA replication, transcription, repair, and recombination.

Pharmacokinetics

Onset

Anti-inflammatory effects within hours; antibacterial effects can be seen within hours of initial dose.

Excretion

Primarily renal for systemically absorbed components; most of the topically applied drug is cleared locally or by tears.

Half life

Local half-life in ocular tissues varies, systemic half-life of absorbed components is longer but systemic levels are very low.

Absorption

Minimal systemic absorption after ocular administration. Local absorption into ocular tissues.

Metabolism

Primarily metabolized in the liver for systemically absorbed components; local metabolism in ocular tissues is minimal.

Side Effects

Contraindications

Viral diseases of the cornea and conjunctiva (e.g., Herpes Simplex Keratitis, Vaccinia, Varicella)
Mycobacterial infection of the eye
Fungal diseases of ocular structures
Hypersensitivity to Dexamethasone, Levofloxacin, or any components of the formulation

Drug Interactions

Systemic corticosteroids

Prolonged concomitant use might increase systemic absorption, though unlikely with typical ophthalmic use.

Storage

Store in a cool, dry place, below 25°C. Protect from light. Do not freeze. Keep out of reach of children.

Overdose

An acute overdose is unlikely with ophthalmic administration. If accidental ingestion occurs, seek medical advice. Management is supportive.

Pregnancy & Lactation

Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution should be exercised when administered to a nursing mother, as small amounts may be excreted in breast milk. Consult a doctor.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

5 ml dropper bottle10 ml dropper bottle

Shelf Life

2 years (unopened); 28 days after opening.

Availability

Pharmacies, Hospitals

Approval Status

Approved by DGDA

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Clinical trials have demonstrated the efficacy and safety of combined Dexamethasone and Levofloxacin ophthalmic solution in treating ocular inflammatory conditions with associated bacterial infection.

Lab Monitoring

Intraocular pressure (IOP) monitoring with prolonged corticosteroid use (especially >10 days)

Doctor Notes

Advise patients to report any severe eye pain, vision changes, or signs of new infection immediately.
Check IOP if using for more than 10 days.
Ensure patient understands proper administration technique to avoid contamination.

Patient Guidelines

Do not use for more than 7-10 days unless directed by a doctor.
Remove contact lenses before application and wait at least 15 minutes before reinserting.
Do not wear contact lenses if you have an eye infection.
Avoid touching the dropper tip to prevent contamination.

Missed Dose Advice

If a dose is missed, apply it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose.