Dexend
Generic Name
Dextroamphetamine Sulfate
Manufacturer
Hypothetical Manufacturer
Country
USA
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dexend 60 mg capsule | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Dextroamphetamine is a central nervous system stimulant used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy. It works by increasing the levels of certain neurotransmitters in the brain.
Uses & Indications
Dosage
Adults
For ADHD: Typically 20-60 mg once daily in the morning for extended-release capsules. Dosage should be individualized and titrated. For Narcolepsy: 5-60 mg daily in divided doses.
Elderly
Initiate with lower doses and monitor closely for side effects due to increased sensitivity.
Renal_impairment
Use with caution. Dose adjustments may be necessary depending on the degree of impairment.
How to Take
Take orally, usually once daily in the morning, with or without food. Capsules should be swallowed whole; do not chew or crush.
Mechanism of Action
Dextroamphetamine works by blocking the reuptake of norepinephrine and dopamine into the presynaptic neuron and increasing the release of these monoamines into the extraneuronal space.
Pharmacokinetics
Onset
30-60 minutes for immediate release; longer for extended release.
Excretion
Primarily renal. Excretion is pH-dependent; increased in acidic urine, decreased in alkaline urine.
Half life
Approximately 10-12 hours in adults.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached within 1-3 hours for immediate release. Extended-release forms have a slower absorption with a biphasic peak.
Metabolism
Primarily hepatic, via hydroxylation and deamination.
Side Effects
Contraindications
- Advanced arteriosclerosis
- Symptomatic cardiovascular disease
- Moderate to severe hypertension
- Hyperthyroidism
- Glaucoma
- Known hypersensitivity or idiosyncrasy to sympathomimetic amines
- During or within 14 days following the administration of monoamine oxidase inhibitors (MAOIs)
- Agitated states
- History of drug abuse
Drug Interactions
MAOIs
Hypertensive crisis
SSRIs
Risk of serotonin syndrome
Antihypertensives
May counteract the hypotensive effect of antihypertensives
Antacids (e.g., sodium bicarbonate)
Increase absorption and prolong half-life of dextroamphetamine
Urinary acidifiers (e.g., ammonium chloride)
Decrease absorption and accelerate excretion
Storage
Store at room temperature (20°C to 25°C), away from moisture and heat. Keep out of reach of children.
Overdose
Symptoms include restlessness, tremor, hyperreflexia, rapid respiration, confusion, assaultiveness, hallucinations, panic states, hyperpyrexia, rhabdomyolysis, and convulsions. Management is primarily supportive.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during lactation as it is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies
Approval Status
Approved by regulatory authorities (e.g., FDA)
Patent Status
Generic available
Clinical Trials
Numerous clinical trials have demonstrated efficacy in improving ADHD symptoms and wakefulness in narcolepsy.
Lab Monitoring
- Blood pressure and heart rate
- Growth in pediatric patients
- Psychiatric status, especially for emergence or worsening of psychotic or manic symptoms
Doctor Notes
- Assess for cardiovascular risk factors prior to initiation and monitor throughout treatment.
- Monitor for signs of abuse and diversion.
- Consider drug holidays for pediatric patients to assess growth and reduce potential for tolerance.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not share this medication with others.
- Inform your doctor about all other medications you are taking.
- Report any new or worsening side effects immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is late in the day (to avoid sleep disturbance). Do not double the dose to catch up.
Driving Precautions
May impair your ability to drive or operate machinery. Exercise caution until you know how this medication affects you.
Lifestyle Advice
- Maintain a healthy diet and exercise routine.
- Avoid late-day doses to prevent sleep disturbances.
- Avoid alcohol while on this medication.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
Related
Medicines
Explore similar medicines to find the best option for your healthcare needs.
Axxo
Square Pharmaceuticals Ltd.
Lotenate Plus
General Pharmaceuticals Ltd.
Exler
Incepta Pharmaceuticals
Azi S
Square Pharmaceuticals Ltd.
Exomi MUPS
Square Pharmaceuticals Ltd.
Timozin
MediCorp Pharma Ltd.
Axovit
Reputable Pharma Ltd.
Exipain
Acme Laboratories Ltd.
Exalin
Square Pharmaceuticals Ltd.
Avilam
Various (e.g., Sanofi as Avil)