Medicine Information

Dexotix

Name: Dexotix
Brand: Dexotix
Rating: 4.5 (117 reviews)

Tablet60 mgAntidepressantATC: N06AB99

Generic Name

Dexotine Hydrochloride 60 mg Tablet

Manufacturer

PharmaCorp Inc.

Country

Bangladesh

Loading images...

Price Details

Current market pricing information

Variant	Unit Price	Strip Price
dexotix 60 mg tablet	৳ 10.00	৳ 40.00

Description

Overview of the medicine

Dexotix 60 mg tablet is an antidepressant medication primarily used to treat major depressive disorder, generalized anxiety disorder, and panic disorder. It works by restoring the balance of a natural substance (serotonin) in the brain.

Uses & Indications

Major Depressive Disorder (MDD)

Generalized Anxiety Disorder (GAD)

Panic Disorder (PD)

Dosage

Adults

Initial dose 30 mg once daily, may be increased to 60 mg once daily after several weeks if needed, based on clinical response and tolerability.

Elderly

Initial dose 15 mg once daily, gradually titrate upwards with caution, considering reduced renal and hepatic function.

Renal_impairment

Mild to moderate renal impairment may require dose adjustment; use with caution in severe impairment.

How to Take

Take Dexotix 60 mg tablet orally once daily, with or without food, as directed by your doctor. Swallow the tablet whole; do not crush, chew, or break it.

Mechanism of Action

Dexotix selectively inhibits the reuptake of serotonin (5-HT) into presynaptic neurons, thereby increasing the concentration of serotonin in the synaptic cleft. This leads to enhanced serotonergic neurotransmission and improvement in mood and anxiety symptoms.

Pharmacokinetics

Onset

Therapeutic effects typically begin within 2-4 weeks, with full effect potentially taking longer.

Excretion

Mainly excreted via urine (60%) and feces (40%) as metabolites.

Half life

Approximately 25-30 hours, allowing for once-daily dosing.

Absorption

Rapidly and well absorbed after oral administration, reaching peak plasma concentrations within 2-4 hours.

Metabolism

Extensively metabolized in the liver, primarily by CYP2D6 and CYP3A4 enzymes, into active and inactive metabolites.

Side Effects

Contraindications

Hypersensitivity to Dexotine or any of its components.
Concomitant use with Monoamine Oxidase Inhibitors (MAOIs).
Uncontrolled narrow-angle glaucoma.

Drug Interactions

Warfarin

May increase the risk of bleeding due to effects on platelet function.

Tricyclic Antidepressants (TCAs)

May increase plasma concentrations of TCAs, requiring dose adjustment.

Monoamine Oxidase Inhibitors (MAOIs)

Increased risk of serotonin syndrome, a potentially life-threatening condition. Concomitant use is contraindicated.

Storage

Store below 25°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose may include nausea, vomiting, dizziness, tremor, somnolence, tachycardia, and rarely, seizures or coma. Management involves supportive care, maintaining airway, monitoring vital signs, and symptomatic treatment. Gastric lavage and activated charcoal may be considered if ingestion is recent.

Pregnancy & Lactation

Consult your doctor before using Dexotix during pregnancy or while breastfeeding. The potential risks and benefits should be carefully weighed. If used in late pregnancy, newborns may experience withdrawal symptoms.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per pack30 tablets per pack

Shelf Life

3 years from the date of manufacture.

Availability

Pharmacies nationwide

Approval Status

Approved by regulatory authorities

Patent Status

Patent protected

Clinical Trials

Dexotix has undergone several clinical trials demonstrating its efficacy and safety for approved indications. Ongoing research continues to explore its potential in other therapeutic areas and its long-term effects.

Lab Monitoring

Periodic monitoring of liver function tests (LFTs) may be advisable during prolonged therapy.
Monitor serum sodium levels, especially in elderly patients or those on diuretics.

Doctor Notes

Emphasize gradual tapering of dose when discontinuing to minimize withdrawal symptoms.
Monitor patients for the emergence or worsening of suicidal ideation, especially at the beginning of treatment or after dose changes.
Assess for potential drug interactions, particularly with other serotonergic agents or drugs metabolized by CYP2D6/CYP3A4.

Patient Guidelines

Take the medicine exactly as prescribed by your doctor; do not stop abruptly without medical advice.
Inform your doctor about any new or worsening symptoms, especially changes in mood or suicidal thoughts.
Avoid alcohol and illicit drugs during treatment.

Missed Dose Advice

If you miss a dose of Dexotix, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at once to make up for a missed dose.

Driving Precautions

Dexotix may cause dizziness, drowsiness, or impaired judgment. Avoid driving or operating heavy machinery until you know how this medicine affects you.