Medicine Information

Dexpoten

Name: Dexpoten
Brand: Dexpoten
Rating: 4.5 (117 reviews)

Syrup10 mg/5 mlAntitussivesATC: R05DA09

Generic Name

Dextromethorphan Hydrobromide

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
dexpoten 10 mg syrup	৳ 80.00	N/A

Description

Overview of the medicine

Dextromethorphan is a cough suppressant used for the temporary relief of coughs caused by minor throat and bronchial irritation, such as from the common cold or flu. It works by affecting the cough reflex in the brain.

Uses & Indications

Temporary relief of cough due to common cold or flu

Cough associated with minor throat and bronchial irritation

Non-productive cough

Dosage

Adults

10-20 mg every 4-6 hours, or 30 mg every 6-8 hours, not to exceed 120 mg in 24 hours.

Elderly

Similar to adult dosage; caution advised for those with comorbidities or polypharmacy.

Renal_impairment

Use with caution; dose reduction may be necessary in severe renal impairment. Consult physician.

How to Take

Administer orally. Use a measuring spoon or cup for accurate dosing.

Mechanism of Action

Dextromethorphan acts centrally on the cough center in the medulla oblongata to elevate the cough threshold, thereby suppressing the cough reflex. It is a non-opioid antitussive.

Pharmacokinetics

Onset

15-30 minutes

Excretion

Mainly excreted in the urine as unchanged drug and metabolites.

Half life

2-4 hours (variable due to CYP2D6 polymorphism)

Absorption

Rapidly absorbed from the gastrointestinal tract.

Metabolism

Extensively metabolized in the liver, primarily by CYP2D6, to its active metabolite, dextrorphan.

Side Effects

Contraindications

Hypersensitivity to dextromethorphan or any component of the formulation
Concurrent use with or within 14 days of discontinuing monoamine oxidase inhibitors (MAOIs)
Asthma exacerbation or severe respiratory depression

Drug Interactions

SSRIs and TCAs

Increased risk of serotonin syndrome when co-administered.

Alcohol and other CNS depressants

May enhance central nervous system (CNS) depression, leading to increased drowsiness or dizziness.

Monoamine Oxidase Inhibitors (MAOIs)

Concurrent use may lead to serotonin syndrome, characterized by hyperthermia, rigidity, mental status changes, and autonomic instability.

CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)

May increase plasma concentrations of dextromethorphan, leading to exaggerated effects and toxicity.

Storage

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include nausea, vomiting, dizziness, drowsiness, blurred vision, ataxia, nystagmus, CNS excitation, and respiratory depression. Severe cases may lead to serotonin syndrome, hallucinations, and coma. Treatment is symptomatic and supportive. Naloxone may be used to reverse CNS and respiratory depression, though dextromethorphan is not an opioid.

Pregnancy & Lactation

Pregnancy Category C. Use only if clearly needed and potential benefits outweigh risks. Consult a doctor before use during pregnancy or lactation.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

60 ml syrup100 ml syrup

Shelf Life

Typically 24 to 36 months from the manufacturing date, consult packaging for exact date.

Availability

Pharmacies and drugstores

Approval Status

Approved (Generally available over-the-counter)

Patent Status

Off-patent

Clinical Trials

Dextromethorphan has been extensively studied and is a well-established antitussive agent with numerous clinical trials supporting its efficacy and safety for cough suppression.

Lab Monitoring

No specific routine lab monitoring is required for therapeutic use. In cases of overdose or suspected interaction with CYP2D6 inhibitors, plasma dextromethorphan levels may be monitored.

Doctor Notes

Educate patients on proper dosing and the potential for abuse, especially with high doses.
Advise patients to avoid concurrent use with alcohol and other CNS depressants.
Counsel patients on serotonin syndrome symptoms when co-prescribing with serotonergic agents.

Patient Guidelines

Do not exceed the recommended dose.
Avoid alcohol while taking this medicine.
If cough persists for more than 7 days, recurs, or is accompanied by fever, rash, or persistent headache, consult a doctor.
May cause drowsiness; avoid driving or operating heavy machinery.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.