Medicine Information

Dianide

Name: Dianide
Brand: Dianide
Rating: 4.5 (117 reviews)

Suspension100 mg/5 mLAntiamoebic, AntibacterialATC: P01AB01

Generic Name

Metronidazole

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
dianide 100 mg suspension	৳ 35.24	N/A

Description

Overview of the medicine

Dianide 100 mg suspension is an antibiotic used to treat various bacterial and parasitic infections. It contains Metronidazole, which works by stopping the growth of certain bacteria and parasites.

Uses & Indications

Amoebiasis (intestinal and hepatic)

Giardiasis

Trichomoniasis

Bacterial vaginosis

Anaerobic bacterial infections

Dosage

Adults

Not typically used in 100 mg suspension form for adults. For amoebiasis, adults usually take 400-800 mg three times daily (as tablets).

Elderly

Similar to adults, with caution in hepatic impairment.

Renal_impairment

Dosage adjustment not usually required for mild to moderate impairment. In severe impairment (CrCl < 10 mL/min), reduce dose by 50% or prolong dosing interval.

How to Take

Shake well before use. Administer orally, usually with or after food to minimize GI upset.

Mechanism of Action

Metronidazole is a nitroimidazole antimicrobial. It enters the organism, and in anaerobic conditions, its nitro group is reduced by electron transport proteins to reactive intermediates. These intermediates bind to and damage DNA, proteins, and cell membranes, leading to cell death.

Pharmacokinetics

Onset

Typically within 1-2 hours after oral administration.

Excretion

Mainly renal (60-80% as metabolites and unchanged drug), some fecal excretion (6-15%).

Half life

Approximately 8 hours (range 6-12 hours).

Absorption

Well absorbed orally, with peak plasma concentrations occurring within 1-2 hours.

Metabolism

Primarily hepatic, via oxidation and glucuronidation, forming hydroxylated and carboxylic acid metabolites.

Side Effects

Contraindications

Hypersensitivity to metronidazole or other nitroimidazole derivatives
First trimester of pregnancy (relative contraindication)
Active central nervous system disease

Drug Interactions

Alcohol

Disulfiram-like reaction (nausea, vomiting, flushing, tachycardia). Avoid alcohol.

Lithium

Increases plasma lithium levels, risk of lithium toxicity.

Warfarin

Potentiates anticoagulant effect, monitor INR.

Disulfiram

Psychotic reactions, avoid concomitant use.

Storage

Store below 30°C in a dry place, protected from light. Do not freeze. Keep out of reach of children.

Overdose

Symptoms include nausea, vomiting, ataxia, and mild disorientation. Treatment is symptomatic and supportive; there is no specific antidote.

Pregnancy & Lactation

Generally avoided in the first trimester of pregnancy; use only if clearly needed in subsequent trimesters. Metronidazole passes into breast milk; consider temporary discontinuation of breastfeeding or alternative treatment.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

60 mL suspension bottle100 mL suspension bottle

Shelf Life

Typically 24-36 months when unopened. Refer to product label for exact expiry date.

Availability

Pharmacies, Hospitals

Approval Status

Approved

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Metronidazole has been extensively studied for decades, demonstrating efficacy in treating various anaerobic and protozoal infections. Ongoing research focuses on resistance patterns and new formulations.

Lab Monitoring

Liver function tests (in patients with hepatic impairment)
Complete blood count (for prolonged therapy)
INR (if co-administered with warfarin)

Doctor Notes

Counsel patients on alcohol avoidance.
Consider liver and renal function in elderly or compromised patients.
Monitor for neurological symptoms with prolonged use.

Patient Guidelines

Complete the full course of treatment even if symptoms improve.
Avoid alcohol during treatment and for 3 days after.
Take with food to minimize stomach upset.

Missed Dose Advice

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.