Medicine Information

Diatus

Name: Diatus
Brand: Diatus
Rating: 4.5 (117 reviews)

Tablet15 mgCough SuppressantsATC: R05DA09

Generic Name

Dextromethorphan Hydrobromide

Manufacturer

Opsonin Pharma Limited

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
diatus 15 mg tablet	৳ 8.00	৳ 80.00

Description

Overview of the medicine

Diatus 15 mg Tablet is an antitussive medication used to relieve cough due to minor throat and bronchial irritation, such as that occurring with common cold or inhaled irritants. It helps to reduce the urge to cough.

Uses & Indications

Temporary relief of cough due to minor throat and bronchial irritation (e.g., common cold, flu)

Suppression of non-productive cough

Dosage

Adults

15-30 mg every 4-8 hours as needed, not to exceed 120 mg in 24 hours.

Elderly

Same as adult dose, but caution advised due to potential for increased sensitivity.

Renal_impairment

Use with caution. Dose reduction may be necessary in severe renal impairment. Consult a doctor.

How to Take

May be taken with or without food. Swallow the tablet whole with water. Do not crush or chew.

Mechanism of Action

Dextromethorphan acts centrally on the cough center in the medulla oblongata to elevate the cough threshold, thereby suppressing cough. It is a non-opioid antitussive.

Pharmacokinetics

Onset

15-30 minutes

Excretion

Primarily renal, as unchanged drug and metabolites.

Half life

Approximately 2-4 hours; can be up to 11 hours in poor metabolizers.

Absorption

Rapidly absorbed from the gastrointestinal tract.

Metabolism

Extensive hepatic metabolism, primarily by cytochrome P450 2D6 (CYP2D6) to its active metabolite dextrorphan.

Side Effects

Contraindications

Hypersensitivity to dextromethorphan or any component of the formulation.
Concurrent use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing MAOI therapy due to risk of serotonin syndrome.
Patients with chronic productive cough, asthma, or other respiratory conditions where cough may be protective.

Drug Interactions

Alcohol and other CNS depressants

Additive central nervous system (CNS) depressant effects may occur, leading to increased drowsiness or dizziness.

Monoamine Oxidase Inhibitors (MAOIs)

Concurrent use may lead to serotonin syndrome, characterized by hyperthermia, rigidity, mental status changes, and autonomic instability.

Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)

Increased risk of serotonin syndrome when co-administered.

Storage

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include nausea, vomiting, dizziness, drowsiness, nystagmus, ataxia, respiratory depression, and in severe cases, hallucinations or coma. Management involves supportive care, activated charcoal if ingestion is recent, and naloxone can reverse severe respiratory depression.

Pregnancy & Lactation

Pregnancy Category C. Use with caution during pregnancy if benefits outweigh risks. Consult a doctor. Limited data available on use during lactation; generally considered low risk but physician consultation is recommended.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

Box containing 10 tabletsBox containing 20 tablets (2x10's)

Shelf Life

Typically 2-3 years from the date of manufacture. Refer to the packaging for specific expiry date.

Availability

Pharmacies

Approval Status

Approved

Patent Status

Generic available

Clinical Trials

Dextromethorphan is a well-established antitussive, and its efficacy has been demonstrated in numerous clinical trials for the symptomatic relief of cough.

Lab Monitoring

No routine laboratory monitoring is typically required.

Doctor Notes

Counsel patients on appropriate use, especially avoiding recreational abuse.
Advise patients about potential drowsiness and interactions with other CNS depressants.
Caution for patients with underlying respiratory conditions like asthma, as cough may be protective.

Patient Guidelines

Do not exceed the recommended dosage.
Avoid concomitant use with alcohol or other sedatives.
If cough persists for more than 7 days, worsens, or is accompanied by fever, rash, or persistent headache, consult a doctor immediately.
Do not use for chronic cough associated with smoking, asthma, or emphysema, or where cough produces excessive phlegm.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

This medication may cause drowsiness or dizziness. Avoid driving or operating heavy machinery until you are aware of how Diatus 15 mg Tablet affects you.