Medicine Information

Diclo-TR

Name: Diclo-TR
Brand: Diclo-TR
Rating: 4.5 (117 reviews)

Capsule (Timed Release)100 mgNon-steroidal Anti-inflammatory Drug (NSAID)ATC: M01AB05

Generic Name

Diclofenac (Timed Release)

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
diclo tr 100 mg capsule	৳ 3.00	N/A

Description

Overview of the medicine

Diclofenac (Timed Release) 100 mg capsule is a non-steroidal anti-inflammatory drug (NSAID) used for the treatment of pain and inflammation associated with various conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute musculoskeletal disorders.

Uses & Indications

Osteoarthritis

Rheumatoid Arthritis

Ankylosing Spondylitis

Acute musculoskeletal disorders

Dysmenorrhea

Dosage

Adults

Usually 100 mg once daily, preferably with food. Max 100 mg/day.

Elderly

Lower doses may be required, monitor for adverse effects. Usually 100 mg once daily.

Renal_impairment

Use with caution; dose adjustment may be necessary for severe impairment. Avoid if GFR < 30 mL/min.

How to Take

Take the capsule whole with a glass of water, preferably with or after food to minimize gastrointestinal upset. Do not chew or crush.

Mechanism of Action

Diclofenac inhibits prostaglandin synthesis by blocking cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing inflammation, pain, and fever.

Pharmacokinetics

Onset

Approximately 1-2 hours (for initial release), sustained effect over 12-24 hours.

Excretion

Primarily excreted via urine (60%) as metabolites and bile (35%) as metabolites.

Half life

About 1-2 hours (parent compound), but active metabolites contribute to prolonged effect. Timed-release extends effective half-life.

Absorption

Well absorbed orally. Timed-release formulation ensures slower and sustained absorption.

Metabolism

Extensively metabolized in the liver (CYP2C9, CYP2C19, CYP3A4) mainly via hydroxylation and glucuronidation.

Side Effects

Contraindications

Hypersensitivity to diclofenac or other NSAIDs
Active gastrointestinal bleeding or ulceration
Severe renal or hepatic impairment
Severe heart failure
Third trimester of pregnancy
Coronary Artery Bypass Graft (CABG) surgery (peri-operative pain)

Drug Interactions

Methotrexate

Increased methotrexate toxicity.

Corticosteroids

Increased risk of gastrointestinal ulceration/bleeding.

Lithium/Digoxin

Increased plasma levels of lithium/digoxin.

Warfarin/Anticoagulants

Increased risk of bleeding.

Diuretics/ACE inhibitors

Reduced antihypertensive effect; increased risk of renal impairment.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms include lethargy, drowsiness, nausea, vomiting, epigastric pain, GI bleeding. Management is symptomatic and supportive; gastric lavage or activated charcoal may be considered within 1 hour of ingestion. No specific antidote.

Pregnancy & Lactation

Avoid in the third trimester of pregnancy due to risk of premature closure of ductus arteriosus. Use with caution in first and second trimesters only if clearly needed. Excreted in breast milk in small amounts; use with caution.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules30 capsules

Shelf Life

Typically 2-3 years from manufacturing date

Availability

Pharmacies, Hospitals

Approval Status

Approved

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Numerous clinical trials support the efficacy and safety of diclofenac in various inflammatory and pain conditions. Timed-release formulations aim to improve patient compliance and reduce dosing frequency.

Lab Monitoring

Complete Blood Count (CBC)
Liver function tests (LFTs)
Renal function tests (RFTs) - especially serum creatinine and BUN
Blood pressure monitoring

Doctor Notes

Always assess patient's cardiovascular and gastrointestinal risk factors before prescribing NSAIDs.
Monitor renal function and blood pressure regularly during long-term therapy.
Consider prescribing proton pump inhibitors (PPIs) for GI protection in high-risk patients.

Patient Guidelines

Take with food or milk to reduce stomach upset.
Do not exceed the prescribed dose.
Report any signs of unusual bleeding, dark stools, or severe stomach pain.
Avoid alcohol while taking this medicine.
Do not chew or crush the capsule.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

Driving Precautions

May cause dizziness or drowsiness. Exercise caution when driving or operating machinery until you know how it affects you.

Lifestyle Advice

Maintain a healthy diet and regular exercise.
Avoid smoking.
Limit alcohol intake.

Alternative Medicines in Bangladesh

Similar medicines available in the market

Diclofenac SR 100 mg (Beximco)Ecofenac TR 100 mg (Square)Olafenac SR 100 mg (Incepta)

Global Brand Names

International brand names for this medicine

General Pharmaceuticals Ltd.

Ophthalmic SuspensionLoteprednol 0.5% / Tobramycin 0.3% Ophthalmic Suspension

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