Diclorex
Generic Name
diclorex-25-mg-tablet
Manufacturer
Specific manufacturer varies by region (e.g., Beximco Pharmaceuticals for Bangladesh)
Country
Bangladesh (example)
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Price Details
Current market pricing information
Variant | Unit Price | Strip Price |
---|---|---|
diclorex 25 mg tablet | ৳ 0.54 | N/A |
Description
Overview of the medicine
Diclorex 25 mg tablet is a non-steroidal anti-inflammatory drug (NSAID) containing Diclofenac Sodium. It is used to relieve pain, swelling, and inflammation in various conditions such as arthritis, muscle aches, and dental pain.
Uses & Indications
Dosage
Adults
Usually 25 mg to 50 mg, 2-3 times daily. Maximum daily dose generally 150 mg.
Elderly
Lower doses may be required; caution advised due to increased risk of adverse effects.
Renal_impairment
Use with caution. Dose reduction or avoidance may be necessary in severe impairment.
How to Take
Take the tablet orally, preferably with or after food, to minimize gastrointestinal discomfort. Do not crush or chew the tablet.
Mechanism of Action
Diclofenac works by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for the synthesis of prostaglandins, mediators of inflammation, pain, and fever. By reducing prostaglandin production, it alleviates these symptoms.
Pharmacokinetics
Onset
Onset of action for pain relief typically within 30-60 minutes.
Excretion
Approximately 60% of the dose is excreted in the urine and 30% in the bile/feces.
Half life
Plasma elimination half-life is approximately 1-2 hours, but therapeutic effects can last longer.
Absorption
Rapid and complete absorption from the gastrointestinal tract, though subject to first-pass metabolism.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C9.
Side Effects
Contraindications
- Hypersensitivity to diclofenac or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Severe heart failure
- Severe renal or hepatic impairment
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration and bleeding.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Antiplatelet agents (e.g., Aspirin)
Increased risk of gastrointestinal bleeding.
ACE inhibitors and Angiotensin II Receptor Blockers (ARBs)
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. In rare cases, hypertension, acute renal failure, respiratory depression, and coma may occur. Management is supportive and symptomatic. Gastric lavage and activated charcoal may be considered within one hour of ingestion.
Pregnancy & Lactation
Pregnancy Category C (D in 3rd trimester or near delivery). Avoid in the third trimester due to potential fetal harm (premature closure of ductus arteriosus). Use with caution in the first and second trimesters only if potential benefit outweighs risk. Diclofenac is excreted in breast milk; therefore, it is generally advised to avoid during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory authorities worldwide
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of diclofenac for its approved indications. Ongoing post-marketing surveillance continues.
Lab Monitoring
- Complete Blood Count (CBC) (for long-term use)
- Renal function tests (Creatinine, BUN)
- Liver function tests (ALT, AST)
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration consistent with patient treatment goals.
- Monitor for signs and symptoms of GI bleeding or cardiovascular events, especially in patients with pre-existing risk factors.
- Assess renal and hepatic function periodically during long-term therapy.
Patient Guidelines
- Take the lowest effective dose for the shortest possible duration.
- Always take with food or milk to reduce stomach upset.
- Do not exceed the prescribed dose.
- Report any signs of stomach pain, black stools, or unusual bleeding/bruising immediately.
- Avoid alcohol while taking this medicine.
- Do not lie down for at least 10 minutes after taking the tablet.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Diclofenac may cause dizziness, drowsiness, or visual disturbances. Patients should be cautioned about operating machinery or driving if they experience these side effects.
Lifestyle Advice
- Maintain a healthy diet and lifestyle.
- Avoid excessive alcohol consumption.
- Regular exercise may help manage chronic pain conditions.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
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