Medicine Information

Diloren

Name: Diloren
Brand: Diloren
Rating: 4.5 (117 reviews)

Gel1% w/wNon-steroidal Anti-inflammatory Drugs (NSAIDs), Topical AnalgesicsATC: M02AA15

Generic Name

Diclofenac Sodium 1% w/w Gel

Manufacturer

Generic Pharmaceutical Company

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
diloren 1 w gel	৳ 40.00	N/A

Description

Overview of the medicine

Diloren 1% w/w Gel contains Diclofenac Sodium, a non-steroidal anti-inflammatory drug (NSAID), used for topical relief of pain and inflammation associated with musculoskeletal conditions.

Uses & Indications

For the local symptomatic relief of pain and inflammation in trauma of the tendons, ligaments, muscles and joints (e.g. due to sprains, strains and bruises).

Localised forms of soft tissue rheumatism (e.g. tendinitis, bursitis, shoulder-hand syndrome and periarthropathy).

For the local symptomatic relief of pain in osteoarthritis of superficial joints (e.g. knee, fingers).

Dosage

Adults

Apply 2 to 4 grams of gel (approx. 2.0 to 2.5 cm long strip) to the affected area 2 to 4 times a day, rubbing it in gently. The amount of gel depends on the size of the affected area.

Elderly

The usual adult dosage applies. No special dose adjustment is required.

Renal_impairment

No specific dose adjustment is required for topical application due to minimal systemic absorption.

How to Take

Apply a small amount of gel thinly to the affected skin area and rub it gently into the skin. Wash hands thoroughly after application, unless hands are the treated area.

Mechanism of Action

Diclofenac inhibits prostaglandin synthesis by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes. This reduces inflammation, pain, and fever.

Pharmacokinetics

Onset

Onset of pain relief can occur within 30 minutes to an hour after application.

Excretion

Metabolites are primarily excreted in the urine (around 60%) and bile (around 35%).

Half life

Systemic plasma half-life is approximately 1-2 hours, but it accumulates in synovial fluid, prolonging local action.

Absorption

Approximately 6% of the applied diclofenac is absorbed systemically after topical application. Absorption is higher in areas with compromised skin barrier.

Metabolism

The small portion absorbed systemically is metabolized in the liver, primarily via hydroxylation and glucuronidation.

Side Effects

Contraindications

Hypersensitivity to diclofenac, aspirin, or other non-steroidal anti-inflammatory drugs (NSAIDs).
History of asthma, urticaria, or acute rhinitis precipitated by aspirin or other NSAIDs.
Third trimester of pregnancy due to risk of premature closure of the ductus arteriosus.
Application to open wounds, infected skin, or mucous membranes.

Drug Interactions

Oral NSAIDs

Concomitant use with oral NSAIDs may lead to an increased incidence of systemic side effects.

Anticoagulants

Theoretical risk of increased bleeding tendency with concomitant use, though systemic absorption is minimal.

Storage

Store below 30°C. Protect from direct sunlight and moisture. Do not freeze. Keep out of reach of children.

Overdose

Overdose is unlikely with topical application due to minimal systemic absorption. If accidentally ingested, symptomatic and supportive treatment should be initiated.

Pregnancy & Lactation

Avoid during the third trimester of pregnancy. Use with caution during the first and second trimesters and during lactation, only if the potential benefits outweigh the risks and under medical advice. Minimal systemic absorption, but potential risks to the fetus/infant should be considered.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

20g tube30g tube50g tube

Shelf Life

Typically 2-3 years from manufacturing date. Check product label for specific expiry.

Availability

Pharmacies, drugstores

Approval Status

Approved in many countries globally

Patent Status

Expired

Clinical Trials

Extensive clinical trials have demonstrated the efficacy and safety of topical diclofenac for musculoskeletal pain and osteoarthritis.

Lab Monitoring

No routine lab monitoring is required for topical diclofenac gel.

Doctor Notes

Emphasize proper application technique: thin layer, gentle rubbing, no occlusive dressings.
Advise patients on duration of use and when to seek further medical advice.
Inform about the very low systemic risk compared to oral NSAIDs.