Medicine Information

Diobis

Name: Diobis
Brand: Diobis
Rating: 4.5 (117 reviews)

Tablet10 mgBeta-blockersATC: C07AB07

Generic Name

Bisoprolol Fumarate

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

Loading images...

Price Details

Current market pricing information

Variant	Unit Price	Strip Price
diobis 10 mg tablet	৳ 16.05	N/A

Description

Overview of the medicine

Diobis 10 mg Tablet contains Bisoprolol Fumarate, a selective beta-1 adrenergic blocking agent, used primarily for the management of hypertension, angina pectoris, and chronic heart failure.

Uses & Indications

Hypertension (high blood pressure)

Angina pectoris (chest pain due to heart disease)

Chronic stable heart failure (in combination with ACE inhibitors, diuretics, and optionally cardiac glycosides)

Dosage

Adults

Hypertension/Angina: Initially 5 mg once daily, maximum 20 mg once daily. Chronic Heart Failure: Initially 1.25 mg once daily, gradually titrated up to a maximum of 10 mg once daily.

Elderly

No dosage adjustment is generally required, but close monitoring is advised.

Renal_impairment

For severe renal impairment (creatinine clearance < 20 mL/min), initial dose of 2.5 mg once daily, maximum 10 mg once daily.

How to Take

Take the tablet orally once daily in the morning, with or without food. Do not chew or crush the tablet.

Mechanism of Action

Bisoprolol selectively blocks beta-1 adrenergic receptors, primarily in the heart. This reduces heart rate, myocardial contractility, and cardiac output, leading to a decrease in blood pressure. It also inhibits the release of renin.

Pharmacokinetics

Onset

Within 2-4 hours

Excretion

Approximately 50% renally excreted unchanged; the remaining 50% is excreted as inactive metabolites via kidneys and feces.

Half life

9-12 hours

Absorption

Well absorbed from the GI tract (approx. 90%). Bioavailability is about 90%.

Metabolism

Approximately 50% metabolized in the liver to inactive metabolites.

Side Effects

Contraindications

Acute heart failure or decompensated heart failure requiring intravenous inotropic therapy
Cardiogenic shock
Second or third degree AV block without a pacemaker
Sick sinus syndrome
Sinoatrial block
Bradycardia (heart rate < 60 beats/min before therapy)
Severe asthma or severe chronic obstructive pulmonary disease
Severe peripheral arterial occlusive disease or Raynaud's syndrome
Pheochromocytoma (untreated)
Metabolic acidosis
Hypersensitivity to Bisoprolol or any excipients

Drug Interactions

NSAIDs

May reduce the hypotensive effect of bisoprolol.

Clonidine

Risk of rebound hypertension upon clonidine withdrawal if beta-blocker is not withdrawn first.

Insulin and oral antidiabetics

May mask symptoms of hypoglycemia and potentiate hypoglycemic effects.

Antiarrhythmics (e.g., disopyramide, amiodarone)

Increased risk of bradycardia and cardiac depression.

Calcium channel blockers (e.g., verapamil, diltiazem)

May increase risk of bradycardia, AV block, and heart failure.

Storage

Store below 30°C, in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms include bradycardia, hypotension, bronchospasm, acute cardiac insufficiency. Management involves supportive and symptomatic treatment, including atropine for severe bradycardia, IV fluids and vasopressors for hypotension, and bronchodilators for bronchospasm.

Pregnancy & Lactation

Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Bisoprolol is excreted in breast milk; advise caution in nursing mothers. Consult a doctor.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per pack30 tablets per pack

Shelf Life

Typically 24-36 months from the date of manufacture.

Availability

Available in pharmacies nationwide

Approval Status

Approved by FDA and DGDA

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Bisoprolol has been extensively studied in various clinical trials demonstrating its efficacy and safety in hypertension, angina, and chronic heart failure (e.g., CIBIS studies for heart failure).

Lab Monitoring

Monitor blood pressure regularly.
Monitor heart rate regularly.
Monitor renal function in patients with kidney impairment.
Monitor liver function periodically.

Doctor Notes

Monitor patient for signs of bradycardia and hypotension, especially during initiation and titration.
Caution in patients with obstructive airway disease or diabetes mellitus.
Emphasize the importance of gradual dose reduction when discontinuing.

Patient Guidelines

Do not stop taking Diobis suddenly without consulting your doctor.
Inform your doctor about all other medications you are taking.
Report any unusual symptoms, especially slow heart rate or severe dizziness.
Follow a healthy lifestyle, including diet and exercise, as advised by your doctor.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose.

Driving Precautions

May cause dizziness or fatigue, especially at the start of treatment or when changing medication. Avoid driving or operating machinery until you know how Diobis affects you.