Medicine Information

Dorakid

Name: Dorakid
Brand: Dorakid
Rating: 4.5 (117 reviews)

Syrup5 mg/5 mlAnti-emetic, ProkineticATC: A03FA03

Generic Name

Domperidone

Manufacturer

Reputable Pharma Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
dorakid syrup	৳ 120.00	N/A

Description

Overview of the medicine

Dorakid Syrup is used to treat nausea and vomiting, especially in children. It also helps in conditions where gastric motility is impaired.

Uses & Indications

Nausea and vomiting of various origins (e.g., drug-induced, post-chemotherapy, post-radiation)

Dyspepsia (feeling of fullness, bloating, heartburn, regurgitation) in some regions

Gastroparesis

Dosage

Adults

Adults and adolescents (≥12 years and ≥35 kg): 10 ml (10 mg) up to 3 times daily, maximum 30 ml (30 mg) per day.

Elderly

Similar to adult dosage, but caution with renal impairment.

Renal_impairment

Dosage reduction may be necessary; consult physician. In severe renal impairment (CrCl <30 mL/min), frequency should be reduced to once or twice daily depending on severity.

How to Take

Take orally, ideally 15-30 minutes before meals. Do not exceed the prescribed dose. Shake well before use.

Mechanism of Action

Domperidone, an active ingredient, works by blocking dopamine D2 receptors in the chemoreceptor trigger zone (CTZ) and in the stomach. This increases gastrointestinal motility and produces an antiemetic effect.

Pharmacokinetics

Onset

Within 30-60 minutes for antiemetic effects.

Excretion

Approximately 66% excreted in feces and 33% in urine as inactive metabolites.

Half life

Approximately 7-9 hours, may be prolonged in severe renal impairment.

Absorption

Rapidly absorbed after oral administration, peak plasma concentrations occur within 30-60 minutes.

Metabolism

Extensively metabolized in the liver by CYP3A4 hydroxylation and N-dealkylation.

Side Effects

Contraindications

Hypersensitivity to domperidone or any component of the syrup
Known prolongation of cardiac QT intervals or significant cardiac disease (e.g., congestive heart failure)
Moderate to severe hepatic impairment
Prolactin-releasing pituitary tumour (prolactinoma)
Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
Gastrointestinal haemorrhage, mechanical obstruction, or perforation

Drug Interactions

Antacids or H2-receptor antagonists

May decrease the oral bioavailability of domperidone. Should be taken after domperidone.

Drugs that prolong QT interval (e.g., Amiodarone, Haloperidol, Quinidine)

Increased risk of cardiac arrhythmias. Concomitant use is contraindicated.

Strong CYP3A4 inhibitors (e.g., Ketoconazole, Erythromycin, Clarithromycin)

Increased plasma levels of domperidone, significantly increasing the risk of QT prolongation. Concomitant use is contraindicated.

Storage

Store below 30°C, away from light and moisture. Do not freeze. Keep out of reach of children.

Overdose

Symptoms of overdose include drowsiness, disorientation, and extrapyramidal reactions, particularly in children. Management involves symptomatic and supportive treatment, including gastric lavage and activated charcoal if appropriate. ECG monitoring is recommended.

Pregnancy & Lactation

Pregnancy Category C. Domperidone should only be used during pregnancy if the potential benefits justify the potential risks to the fetus. It is excreted in breast milk and should not be used during lactation unless the expected benefits outweigh the risks to the infant.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

30 ml syrup60 ml syrup100 ml syrup

Shelf Life

Typically 24-36 months from manufacturing date.

Availability

Available in pharmacies and hospitals

Approval Status

Approved by regulatory bodies like DGDA

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Numerous clinical trials have evaluated domperidone's efficacy and safety for various indications, including its cardiac safety profile which has led to stricter dosing recommendations.

Lab Monitoring

ECG monitoring in patients with pre-existing cardiac conditions or at risk for QT prolongation.

Doctor Notes

Emphasize the importance of lowest effective dose and shortest duration due to cardiac risks.
Screen for cardiac risk factors and co-medications that prolong QT interval.
Educate patients on symptoms of cardiac arrhythmias and extrapyramidal effects.

Patient Guidelines

Take the syrup as directed by your doctor, do not exceed the prescribed dose.
Take it 15-30 minutes before meals for best absorption.
Report any unusual side effects, especially palpitations or fainting, to your doctor immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.