Medicine Information

Doximet

Name: Doximet
Brand: Doximet
Rating: 4.5 (117 reviews)

Capsule100 mgTetracycline AntibioticATC: J01AA02

Generic Name

Doxycycline

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
doximet 100 mg capsule	৳ 2.50	N/A

Description

Overview of the medicine

Doximet 100 mg Capsule contains Doxycycline, which is a broad-spectrum tetracycline antibiotic used to treat various bacterial infections including respiratory tract infections, urinary tract infections, skin infections, sexually transmitted infections, rickettsial infections, and for malaria prophylaxis. It works by stopping the growth of bacteria.

Uses & Indications

Respiratory tract infections (e.g., bronchitis, pneumonia)

Urinary tract infections

Skin and soft tissue infections (e.g., acne vulgaris)

Sexually transmitted infections (e.g., chlamydia, gonorrhea, syphilis)

Rickettsial infections (e.g., Rocky Mountain spotted fever, typhus)

Malaria prophylaxis and treatment

Anthrax (post-exposure)

Periodontitis

Lyme disease

Dosage

Adults

The usual adult dose is 200 mg on the first day (administered as 100 mg every 12 hours) followed by a maintenance dose of 100 mg once daily. For severe infections, 100 mg every 12 hours may be continued.

Elderly

No specific dose adjustment is generally required for elderly patients, but caution is advised in those with significant hepatic impairment.

Renal_impairment

No dosage adjustment is needed in patients with impaired renal function, which is a unique advantage among tetracyclines.

How to Take

Take the capsule orally with a full glass of water (approx. 240 mL) to prevent esophageal irritation and ulceration. It can be taken with food or milk if gastric irritation occurs, but avoid dairy products, antacids, or iron preparations within 1-2 hours of taking Doximet, as they can interfere with absorption. Remain in an upright position for at least 30 minutes after taking the medicine.

Mechanism of Action

Doxycycline inhibits bacterial protein synthesis by reversibly binding to the 30S ribosomal subunit of susceptible bacteria, thereby preventing the attachment of aminoacyl-tRNA to the ribosomal acceptor site. This action prevents the elongation of the peptide chain, leading to bacteriostatic effects.

Pharmacokinetics

Onset

Peak plasma concentrations are usually reached within 1-3 hours after oral administration.

Excretion

Mainly excreted in urine and feces as inactive compounds, with approximately 40% eliminated via the kidneys within 72 hours and a significant portion via the gastrointestinal tract.

Half life

Plasma half-life is 16-22 hours, allowing for once or twice daily dosing.

Absorption

Well absorbed orally (approximately 90-100%) in the fasting state. Absorption is not significantly affected by food, although dairy products and antacids may reduce it.

Metabolism

Minimal hepatic metabolism; primarily undergoes enterohepatic recirculation.

Side Effects

Contraindications

Hypersensitivity to Doxycycline or any other tetracycline antibiotics.
Pregnancy (especially during the latter half) due to potential for permanent tooth discoloration and bone growth retardation in the fetus.
Lactation, as it passes into breast milk.
Children under 8 years of age (risk of permanent tooth discoloration).

Drug Interactions

Warfarin

Doxycycline may potentiate the anticoagulant effect of warfarin, requiring monitoring of INR and possible dose adjustment.

Penicillins

Tetracyclines can interfere with the bactericidal action of penicillins. Avoid concomitant use.

Methotrexate

May increase the serum concentration of methotrexate, potentially increasing toxicity.

Oral contraceptives

May reduce the effectiveness of oral contraceptives. Advise patients to use an alternative or additional method of contraception.

Retinoids (e.g., isotretinoin)

Risk of increased intracranial pressure (pseudotumor cerebri). Avoid concomitant use.

Antacids containing aluminum, calcium, magnesium, and iron preparations

Can decrease the absorption of Doxycycline. Take Doxycycline 1-2 hours before or 2-3 hours after these products.

Storage

Store in a cool, dry place (below 30°C), away from direct sunlight and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose may include nausea, vomiting, and diarrhea. In case of overdose, discontinue the drug, institute gastric lavage, and provide supportive therapy. Hemodialysis is not effective in removing Doxycycline.

Pregnancy & Lactation

Doxycycline is contraindicated in the second and third trimesters of pregnancy due to the risk of permanent tooth discoloration and inhibition of bone growth in the fetus. It passes into breast milk and is generally not recommended during lactation. Alternative antibiotics should be considered.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules per strip30 capsules per box

Shelf Life

Typically 2-3 years from the date of manufacture.

Availability

Available in pharmacies, hospitals

Approval Status

Approved by regulatory bodies (e.g., FDA, DGDA)

Patent Status

Off-patent (generic available)

WHO Essential Medicine

Yes

Clinical Trials

Doxycycline has undergone extensive clinical trials and is a well-established antibiotic. Ongoing research explores new indications and formulations.

Lab Monitoring

Liver function tests (for prolonged therapy or in patients with pre-existing hepatic impairment)
Renal function tests (although Doxycycline is unique among tetracyclines in not requiring dose adjustment for renal impairment, monitoring may be warranted in some cases)

Doctor Notes

Emphasize strict adherence to administration guidelines to prevent esophageal irritation/ulceration.
Advise patients about photosensitivity and the importance of sun protection.
Contraindicated in pregnant women (2nd/3rd trimester) and children under 8 years due to tooth discoloration risk.
Caution with concomitant use of antacids, iron, warfarin, and oral contraceptives.

Patient Guidelines

Take with a full glass of water and remain upright for at least 30 minutes to prevent esophageal irritation.
Avoid dairy products, antacids, or iron preparations within 1-2 hours of taking Doximet.
Protect yourself from direct sunlight or artificial UV light, as Doxycycline can cause photosensitivity. Use sunscreen and wear protective clothing.
Complete the full course of treatment as prescribed, even if symptoms improve, to prevent antibiotic resistance.
Do not use in children under 8 years of age or during pregnancy/lactation without consulting a doctor.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Doxycycline is generally not known to impair the ability to drive or operate machinery. However, if you experience dizziness or visual disturbances, avoid such activities.