Medicine Information

Doxseem

Name: Doxseem
Brand: Doxseem
Rating: 4.5 (117 reviews)

Capsule100 mgTetracycline AntibioticsATC: J01AA02

Generic Name

Doxycycline

Manufacturer

Example Pharmaceutical Company Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
doxseem 100 mg capsule	৳ 2.50	N/A

Description

Overview of the medicine

Doxycycline is a broad-spectrum tetracycline antibiotic used to treat a wide variety of bacterial infections, including respiratory tract infections, urinary tract infections, skin infections, sexually transmitted infections, and certain parasitic infections. It works by inhibiting bacterial protein synthesis.

Uses & Indications

Respiratory tract infections (e.g., bronchitis, pneumonia)

Urinary tract infections

Skin and soft tissue infections (e.g., acne, cellulitis)

Sexually transmitted infections (e.g., chlamydia, gonorrhea, syphilis)

Lyme disease

Malaria prophylaxis

Cholera

Rickettsial infections (e.g., Rocky Mountain spotted fever, typhus)

Dosage

Adults

Typical adult dose for most infections: 100 mg orally every 12 hours on the first day, followed by 100 mg once daily. For severe infections, 100 mg every 12 hours. For acne: 50-100 mg once daily.

Elderly

No specific dosage adjustment is generally required for elderly patients, but caution is advised in those with significant hepatic impairment.

Renal_impairment

No dosage adjustment is necessary for patients with renal impairment, as doxycycline is primarily excreted non-renally.

How to Take

Take Doxseem capsules with a full glass of water (approx. 240 mL) to reduce the risk of esophageal irritation and ulceration. It can be taken with food or milk to minimize gastrointestinal upset, but avoid taking it with dairy products, antacids, or iron supplements within 2 hours of dose due to reduced absorption. Remain upright for at least 30-60 minutes after taking the capsule.

Mechanism of Action

Doxycycline inhibits bacterial protein synthesis by reversibly binding to the 30S ribosomal subunit of susceptible bacteria, thereby preventing the attachment of aminoacyl-tRNA to the ribosomal A site. This leads to the inhibition of peptide chain elongation and bacterial growth.

Pharmacokinetics

Onset

Antibacterial effects typically begin within 1-2 hours after administration.

Excretion

Primarily excreted unchanged in the feces via biliary and intestinal secretion. A smaller portion is excreted in the urine.

Half life

Plasma elimination half-life ranges from 16 to 22 hours, which allows for once or twice daily dosing.

Absorption

Rapidly and almost completely absorbed from the gastrointestinal tract after oral administration, with bioavailability typically between 90-100%. Peak plasma concentrations are reached in 2-4 hours.

Metabolism

Partially metabolized in the liver to inactive metabolites. About 20% of the dose is metabolized.

Side Effects

Contraindications

Hypersensitivity to doxycycline or any other tetracycline antibiotic
Children under 8 years of age (due to potential for permanent tooth discoloration and enamel hypoplasia)
Pregnancy and lactation

Drug Interactions

Warfarin

May enhance the anticoagulant effect of warfarin, requiring monitoring of INR.

Penicillins

Tetracyclines may interfere with the bactericidal action of penicillin. Avoid concomitant use.

Oral contraceptives

May reduce the effectiveness of oral contraceptives, requiring additional birth control methods.

Barbiturates, carbamazepine, phenytoin

May decrease doxycycline half-life through enzyme induction.

Antacids, iron preparations, calcium-containing foods/supplements

Decreased absorption of doxycycline. Administer 2-3 hours apart.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

In case of overdose, gastrointestinal symptoms (nausea, vomiting, diarrhea) are most common. Management includes gastric lavage if ingestion is recent, followed by symptomatic and supportive treatment. Dialysis does not effectively remove doxycycline from the blood.

Pregnancy & Lactation

Doxycycline is contraindicated during pregnancy due to the risk of permanent tooth discoloration and skeletal effects in the fetus. It is also contraindicated during lactation as it is excreted in breast milk and can cause similar adverse effects in nursing infants.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules per strip5 strips per box (50 capsules)

Shelf Life

Usually 24-36 months from the date of manufacture.

Availability

Available in pharmacies and hospitals

Approval Status

Approved by relevant authorities (e.g., DGDA, FDA)

Patent Status

Patent expired

WHO Essential Medicine

Yes

Clinical Trials

Doxycycline is a well-established drug with extensive clinical trial data supporting its efficacy and safety for various indications. Ongoing research explores new applications, such as anti-inflammatory roles.

Lab Monitoring

For prolonged therapy, periodic laboratory evaluation of organ systems, including hematopoietic, renal, and hepatic studies, is recommended.

Doctor Notes

Emphasize patient education regarding administration to prevent esophageal injury.
Advise patients on strict sun protection measures due to photosensitivity.
Review potential drug interactions, especially with anticoagulants and oral contraceptives.

Patient Guidelines

Take the medicine exactly as prescribed by your doctor and complete the full course of treatment, even if symptoms improve.
Take with plenty of water to prevent esophageal irritation. Avoid lying down for at least 30-60 minutes after taking.
Avoid direct sunlight and use sunscreen/protective clothing as doxycycline can cause photosensitivity.
Avoid taking with dairy products, antacids, or iron supplements. If necessary, take them 2-3 hours apart.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Doxycycline generally does not impair the ability to drive or operate machinery. However, if you experience dizziness or visual disturbances, avoid such activities.

Lifestyle Advice

Stay well-hydrated by drinking plenty of fluids throughout the day.
Protect your skin from sun exposure; wear hats, long sleeves, and use high-SPF sunscreen.