Medicine Information

Duofix

Name: Duofix
Brand: Duofix
Rating: 4.5 (117 reviews)

TabletCefixime 250 mg + Clavulanic Acid 125 mgAntibiotic (3rd generation Cephalosporin + Beta-lactamase inhibitor)ATC: J01DD08 (Cefixime)

Generic Name

Cefixime + Clavulanic Acid

Manufacturer

Incepta Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
duofix 375 mg tablet	৳ 10.00	৳ 100.00

Description

Overview of the medicine

Duofix-375 mg tablet is a combination antibiotic containing Cefixime (a 3rd generation cephalosporin) and Clavulanic Acid (a beta-lactamase inhibitor). It is used to treat a wide range of bacterial infections.

Uses & Indications

Uncomplicated urinary tract infections (UTI)

Upper and lower respiratory tract infections (e.g., bronchitis, pneumonia)

Otitis media (middle ear infection)

Pharyngitis and tonsillitis

Skin and soft tissue infections

Acute bacterial exacerbations of chronic bronchitis

Dosage

Adults

The usual adult dose is one Duofix-375 mg tablet (Cefixime 250 mg + Clavulanic Acid 125 mg) orally every 12 hours for 7 to 14 days, depending on the severity and type of infection.

Elderly

No specific dose adjustment is generally required for elderly patients with normal renal function. Dose should be adjusted in case of renal impairment.

Renal_impairment

Dose adjustment is necessary for patients with severe renal impairment (creatinine clearance < 30 mL/min). Consult a physician for specific recommendations.

How to Take

Take the tablet orally with a glass of water, with or without food. It is recommended to take it at regular intervals.

Mechanism of Action

Cefixime inhibits bacterial cell wall synthesis, leading to bacterial cell lysis and death. Clavulanic Acid inactivates a wide range of beta-lactamase enzymes produced by bacteria, which would otherwise degrade Cefixime, thereby extending Cefixime's antibacterial spectrum.

Pharmacokinetics

Onset

Peak plasma concentrations are achieved in approximately 2-6 hours for Cefixime and 1-2 hours for Clavulanic Acid.

Excretion

Cefixime is primarily eliminated by renal excretion. Clavulanic Acid is also largely excreted renally.

Half life

Cefixime has a half-life of 3-4 hours. Clavulanic Acid has a half-life of approximately 1 hour.

Absorption

Both Cefixime and Clavulanic Acid are well absorbed from the gastrointestinal tract after oral administration. Cefixime's bioavailability is approximately 40-50%. Clavulanic acid is also well absorbed.

Metabolism

Cefixime undergoes limited hepatic metabolism. Clavulanic Acid is extensively metabolized.

Side Effects

Contraindications

Hypersensitivity to Cefixime, Clavulanic Acid, other cephalosporins, penicillins, or any component of the formulation.
History of severe allergic reactions to beta-lactam antibiotics.

Drug Interactions

Probenecid

Increases plasma concentrations of Cefixime by decreasing its renal tubular secretion.

Carbamazepine

Concomitant administration may increase plasma levels of carbamazepine.

Oral Anticoagulants (e.g., Warfarin)

May increase INR and risk of bleeding. Close monitoring is advised.

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

Overdose

In case of overdose, gastric lavage may be indicated. No specific antidote exists. Treatment should be symptomatic and supportive.

Pregnancy & Lactation

Use in pregnancy only if clearly needed and the potential benefits outweigh the potential risks to the fetus. Small amounts of Cefixime are excreted in breast milk; caution should be exercised when administered to a nursing mother. Consult your doctor.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

6 tablets per pack10 tablets per pack

Shelf Life

Typically 2 to 3 years from the manufacturing date. Refer to the package for the exact expiry date.

Availability

Pharmacies, Hospitals

Approval Status

Approved

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Ongoing clinical trials focus on assessing efficacy in various bacterial infections, evaluating resistance patterns, and exploring optimal dosing regimens for specific patient populations.

Lab Monitoring

Renal function tests (for prolonged therapy or in patients with pre-existing renal impairment)
Liver function tests (if signs of hepatic dysfunction appear)
Complete blood count (for prolonged therapy)

Doctor Notes

Before initiating therapy, inquire about prior hypersensitivity reactions to cephalosporins, penicillins, or other drugs.
Adjust dosage in patients with significant renal impairment.
Advise patients on the importance of completing the full course of therapy to minimize resistance development.

Patient Guidelines

Complete the entire prescribed course of medication, even if symptoms improve, to prevent recurrence and development of antibiotic resistance.
Do not share your medication with others.
Report any severe or persistent side effects to your doctor.
Take the tablet with plenty of water.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.

Driving Precautions

This medicine may cause dizziness in some individuals. If you experience dizziness, avoid driving or operating machinery until you know how it affects you.

Lifestyle Advice

Maintain good personal hygiene to prevent infections.
Avoid self-medication and always consult a healthcare professional before starting any antibiotic.