Eflow
Generic Name
Eplerenone
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| eflow 25 mg tablet | ৳ 30.00 | ৳ 300.00 |
Description
Overview of the medicine
Eplerenone is a selective aldosterone receptor antagonist used to treat heart failure after a heart attack and high blood pressure.
Uses & Indications
Dosage
Adults
For hypertension, initial 50 mg once daily, adjusted based on response up to 50 mg twice daily. For heart failure post-MI, initial 25 mg once daily, titrated to 50 mg once daily within 4 weeks.
Elderly
No specific dosage adjustment usually needed, but monitor renal function.
Renal_impairment
Contraindicated in severe renal impairment. Dose adjustment needed for moderate impairment (e.g., initial 25 mg every other day).
How to Take
Oral, with or without food.
Mechanism of Action
Eplerenone selectively binds to the mineralocorticoid receptor, blocking the binding of aldosterone. This prevents aldosterone-mediated sodium reabsorption and potassium excretion, leading to diuresis and reduction in blood pressure.
Pharmacokinetics
Onset
Antihypertensive effects typically seen within 4 weeks. Heart failure benefits seen over longer term.
Excretion
Approximately two-thirds excreted in urine and one-third in feces, mainly as inactive metabolites.
Half life
Approximately 4-6 hours.
Absorption
Rapidly absorbed. Peak plasma concentration reached within 1.5-2 hours. Bioavailability not affected by food.
Metabolism
Primarily metabolized by CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to eplerenone
- Hyperkalemia (serum potassium > 5.0 mmol/L)
- Severe renal impairment (CrCl < 30 mL/min)
- Severe hepatic impairment
- Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole)
- Concomitant use with other potassium-sparing diuretics or potassium supplements
Drug Interactions
NSAIDs
May reduce antihypertensive effect and increase risk of renal impairment and hyperkalemia.
ACE inhibitors/ARBs
Increased risk of hyperkalemia.
Strong CYP3A4 inhibitors
Significantly increase eplerenone levels (contraindicated).
Potassium-sparing diuretics/supplements
Increased risk of hyperkalemia.
Storage
Store below 30°C, protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include hypotension, hyperkalemia. Management is supportive, including discontinuing eplerenone, monitoring electrolytes, and supportive measures. Eplerenone is not removed by hemodialysis.
Pregnancy & Lactation
Use only if clearly needed. Limited data in pregnant women. Unknown if excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years (refer to product specific packaging)
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Generic available
Clinical Trials
Key studies include the EPHESUS trial, which demonstrated improved survival in heart failure patients post-MI.
Lab Monitoring
- Serum potassium
- Renal function (creatinine, eGFR)
Doctor Notes
- Monitor serum potassium and renal function closely, particularly at initiation and dose titration.
- Avoid concomitant use with strong CYP3A4 inhibitors and other potassium-sparing agents.
- Educate patients on symptoms of hyperkalemia and importance of regular lab monitoring.
Patient Guidelines
- Take as directed, do not stop without consulting a doctor.
- Report any signs of high potassium (muscle weakness, irregular heartbeat).
- Avoid potassium supplements or salt substitutes containing potassium.
- Regular blood tests will be needed.
Missed Dose Advice
Take the missed dose as soon as remembered unless it's almost time for the next dose. Do not double the dose.
Driving Precautions
May cause dizziness. Patients should be cautious if driving or operating machinery.
Lifestyle Advice
- Maintain a healthy diet, limit high-potassium foods if advised.
- Regular exercise (as advised by doctor).
- Limit alcohol intake.
- Monitor blood pressure at home if recommended.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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