Medicine Information

Emenil Plus

Name: Emenil Plus
Brand: Emenil Plus
Rating: 4.5 (117 reviews)

Tablet25 mgAntiemetic, AntivertigoATC: N05AB04

Generic Name

Prochlorperazine Maleate

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
emenil plus 25 mg tablet	৳ 3.00	৳ 30.00

Description

Overview of the medicine

Emenil Plus 25 mg Tablet contains Prochlorperazine Maleate, a phenothiazine derivative. It is primarily used to treat severe nausea, vomiting, vertigo, and sometimes anxiety or as an adjunct in psychotic disorders.

Uses & Indications

Treatment of severe nausea and vomiting

Management of vertigo (e.g., associated with Meniere's disease)

Short-term management of severe anxiety

Adjunctive treatment in psychotic disorders (lower doses)

Dosage

Adults

For severe nausea/vomiting or vertigo: 1 tablet (25 mg) once daily, or as directed by physician. For severe cases, dosage may be adjusted by a doctor.

Elderly

Lower doses are recommended due to increased sensitivity to side effects. Start with 5-10 mg daily and adjust cautiously.

Renal_impairment

Use with caution. Dose reduction may be necessary in severe renal impairment. Consult physician.

How to Take

Take orally with or without food. Swallow the tablet whole with water.

Mechanism of Action

Prochlorperazine blocks dopamine D2 receptors in the chemoreceptor trigger zone (CTZ) in the brain, thereby inhibiting signals to the vomiting center. It also possesses mild anticholinergic, antihistaminic, and alpha-adrenergic blocking effects.

Pharmacokinetics

Onset

Oral: 30-40 minutes; Intramuscular: 10-20 minutes.

Excretion

Mainly through urine and feces (via bile).

Half life

Variable, typically 6-8 hours for a single dose, longer with chronic use.

Absorption

Well absorbed orally but undergoes extensive first-pass metabolism.

Metabolism

Extensively metabolized in the liver, primarily via oxidation, hydroxylation, and glucuronidation.

Side Effects

Contraindications

Hypersensitivity to prochlorperazine or other phenothiazines
Comatose states or severe central nervous system depression
Bone marrow depression or blood dyscrasias
Children under 2 years or weighing less than 9 kg
Angle-closure glaucoma, prostatic hypertrophy (due to anticholinergic effects)

Drug Interactions

Antihypertensives

Enhanced hypotensive effect.

Dopamine agonists (e.g., bromocriptine, levodopa)

Reduced therapeutic effect of dopamine agonists due to dopamine receptor blockade.

CNS depressants (e.g., alcohol, opioids, sedatives)

Increased sedation and central nervous system depression.

Anticholinergic agents (e.g., antihistamines, tricyclic antidepressants)

Potentiated anticholinergic effects (e.g., dry mouth, blurred vision, constipation).

Storage

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include severe drowsiness, confusion, extrapyramidal symptoms, hypotension, and seizures. Treatment is supportive and symptomatic, focusing on maintaining vital functions.

Pregnancy & Lactation

Not recommended during pregnancy or lactation unless clearly essential and the benefits outweigh the risks. Prochlorperazine is excreted into breast milk. Consult your doctor.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per strip30 tablets per box

Shelf Life

Typically 2-3 years from manufacturing date.

Availability

Available in pharmacies and hospitals

Approval Status

Approved globally, including by DGDA (Bangladesh)

Patent Status

Off-patent (Generic available)

WHO Essential Medicine

Yes

Clinical Trials

Prochlorperazine has been extensively studied in clinical trials for its efficacy in treating nausea, vomiting, vertigo, and psychiatric conditions since its introduction in the mid-20th century.

Lab Monitoring

Liver function tests (periodically, especially with long-term use)
Complete Blood Count (CBC) if long-term treatment is planned

Doctor Notes

Educate patients about potential extrapyramidal symptoms and orthostatic hypotension.
Consider lower doses in elderly patients and those with hepatic or renal impairment.
Avoid concurrent use with other CNS depressants.
Monitor for signs of Neuroleptic Malignant Syndrome, especially during initiation or dose escalation.

Patient Guidelines

Do not exceed the recommended dose.
Avoid alcohol while taking this medicine.
Report any unusual movements or severe side effects to your doctor immediately.
May cause drowsiness; use caution when driving or operating machinery.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Emenil Plus 25 mg Tablet may cause drowsiness, dizziness, or blurred vision. Do not drive or operate heavy machinery until you know how this medicine affects you.