Medicine Information

Emetus

Name: Emetus
Brand: Emetus
Rating: 4.5 (117 reviews)

Oral Solution4 mgAnti-emeticATC: A04AA01

Generic Name

Ondansetron

Manufacturer

Popular Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
emetus 4 mg oral solution	৳ 50.00	N/A

Description

Overview of the medicine

Ondansetron is an anti-emetic drug used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, and surgery.

Uses & Indications

Prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy.

Prevention of nausea and vomiting associated with moderately emetogenic cancer chemotherapy.

Prevention of postoperative nausea and vomiting.

Dosage

Adults

Chemotherapy-induced Nausea and Vomiting (CINV): 8 mg orally 30 minutes before chemotherapy, then 8 mg every 8 hours for up to 1-2 days after chemotherapy. Postoperative Nausea and Vomiting (PONV): 16 mg orally one hour before anesthesia.

Elderly

Similar to adult dosage, but half-life may be prolonged.

Renal_impairment

No dosage adjustment required.

How to Take

May be taken with or without food. Measure the dose carefully using the provided measuring device.

Mechanism of Action

Ondansetron selectively antagonizes 5-HT3 receptors located both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone (CTZ) in the area postrema. This action blocks the initiation of the vomiting reflex.

Pharmacokinetics

Onset

Within 30 minutes for oral administration.

Excretion

Excreted via urine (approx. 5%) and feces.

Half life

Approximately 3-5 hours (adults), 6 hours (elderly).

Absorption

Rapidly and completely absorbed from the GI tract. Peak plasma concentrations are reached in about 1.5 hours.

Metabolism

Primarily metabolized in the liver by hydroxylation, followed by glucuronide or sulfate conjugation.

Side Effects

Contraindications

Hypersensitivity to ondansetron or any component of the formulation.
Concomitant use with apomorphine.

Drug Interactions

Tramadol

May reduce the analgesic effect of tramadol.

Apomorphine

Concomitant use is contraindicated due to increased risk of profound hypotension and loss of consciousness.

Phenytoin, Carbamazepine, Rifampicin

May decrease ondansetron plasma levels.

Serotonergic drugs (e.g., SSRIs, SNRIs)

Increased risk of serotonin syndrome.

Storage

Store at room temperature (20-25°C), away from light and moisture. Do not freeze.

Overdose

Symptoms include visual disturbances, severe constipation, hypotension, and vasovagal episodes with transient AV block. Treatment is supportive.

Pregnancy & Lactation

Pregnancy Category B. Use in pregnancy only if clearly needed. Excreted in breast milk, caution advised.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

50 mL bottle100 mL bottle

Shelf Life

Typically 24 months from manufacturing date.

Availability

Pharmacies, Hospitals

Approval Status

FDA approved (generic)

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have established Ondansetron's efficacy and safety in preventing chemotherapy-induced, radiation-induced, and postoperative nausea and vomiting.

Lab Monitoring

No routine lab monitoring is generally required.

Doctor Notes

Ensure correct diagnosis of emesis etiology.
Advise patients on potential for constipation and how to manage it.
Monitor for QT prolongation in high-risk patients.

Patient Guidelines

Do not take more than the prescribed dose.
Inform your doctor if you have heart problems or liver disease.
Report any unusual side effects promptly.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.