Medicine Information

Encarlev

Name: Encarlev
Brand: Encarlev
Rating: 4.5 (117 reviews)

Tablet100 mgAntiepilepticATC: N03AX14

Generic Name

Levetiracetam

Manufacturer

Incepta Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
encarlev 100 mg tablet	৳ 25.00	৳ 250.00

Description

Overview of the medicine

Encarlev 100 mg Tablet contains Levetiracetam, an antiepileptic drug used to treat various types of seizures in adults and children. It works by affecting nerve cells in the brain to reduce the frequency of seizures.

Uses & Indications

Partial-onset seizures with or without secondary generalization

Myoclonic seizures in patients with juvenile myoclonic epilepsy

Primary generalized tonic-clonic seizures

Dosage

Adults

Initial dose 500 mg twice daily, may be increased by 500 mg twice daily every 2-4 weeks to a maximum of 1500 mg twice daily.

Elderly

Dosage adjustment may be considered based on renal function.

Renal_impairment

Requires significant dose reduction and careful monitoring. Dosage intervals should be increased.

How to Take

Administer orally with or without food. Tablets should be swallowed whole with liquid and not chewed or crushed.

Mechanism of Action

Levetiracetam's precise mechanism is not fully understood, but it is believed to involve binding to synaptic vesicle glycoprotein 2A (SV2A) in the brain, thereby modulating neurotransmitter release and preventing hypersynchronization of neuronal activity.

Pharmacokinetics

Onset

Within a few days of consistent dosing, but immediate seizure control may vary.

Excretion

Primarily excreted unchanged in the urine (about 66%), with a smaller fraction as inactive metabolite.

Half life

Approximately 6-8 hours in adults, and shorter (4-5 hours) in children.

Absorption

Rapidly and almost completely absorbed after oral administration, with peak plasma concentrations occurring within 1-1.5 hours. Bioavailability is near 100%.

Metabolism

Minimal metabolism in humans (less than 3% via enzymatic hydrolysis), not extensively metabolized by hepatic cytochrome P450 system.

Side Effects

Contraindications

Hypersensitivity to Levetiracetam or any components of the formulation

Drug Interactions

Phenytoin

No significant pharmacokinetic interaction.

Valproate

No significant pharmacokinetic interaction.

Oral Contraceptives

No effect on the pharmacokinetics of oral contraceptives.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include somnolence, agitation, aggression, depressed level of consciousness, respiratory depression, and coma. Treatment is supportive, including gastric lavage or induced emesis, and symptomatic treatment. Hemodialysis can remove Levetiracetam from the body.

Pregnancy & Lactation

Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in human milk, so caution is advised during breastfeeding.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

30 tablets (3x10)50 tablets (5x10)

Shelf Life

Typically 2-3 years from manufacturing date

Availability

Pharmacies, hospitals

Approval Status

Approved by DGDA

Patent Status

Generic available (Patent expired for Levetiracetam)

WHO Essential Medicine

Yes

Clinical Trials

Extensively studied in numerous clinical trials demonstrating efficacy and safety in various seizure types. Ongoing trials may explore new indications or formulations.

Lab Monitoring

Renal function tests (especially in elderly or renally impaired patients)

Doctor Notes

Counsel patients on potential CNS side effects, especially at treatment initiation.
Monitor for signs of psychiatric symptoms or suicidal ideation.
Adjust dose carefully in patients with renal impairment.

Patient Guidelines

Do not stop taking this medicine suddenly without consulting your doctor, as it may worsen seizures.
Report any new or worsening symptoms of depression, suicidal thoughts, or unusual changes in mood or behavior to your doctor immediately.
Avoid driving or operating machinery until you know how this medicine affects you.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose.

Driving Precautions

Levetiracetam may cause dizziness, somnolence, and other central nervous system effects. Patients should be advised not to drive or operate hazardous machinery until they have gained sufficient experience on Levetiracetam to gauge whether it adversely affects their ability to drive or operate hazardous machinery.