Medicine Information

Ertu

Name: Ertu
Brand: Ertu
Rating: 4.5 (117 reviews)

Tablet5 mgAntidiabetic, SGLT2 InhibitorATC: A10BK04

Generic Name

Ertugliflozin 5 mg Tablet

Manufacturer

Generic Pharmaceutical Company

Country

Varies by manufacturer

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
ertu 5 mg tablet	৳ 22.00	৳ 220.00

Description

Overview of the medicine

Ertugliflozin is an SGLT2 inhibitor used to improve glycemic control in adults with type 2 diabetes mellitus and to reduce the risk of major adverse cardiovascular events in certain patients.

Uses & Indications

As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

To reduce the risk of major adverse cardiovascular events in adults with type 2 diabetes mellitus and established cardiovascular disease.

Dosage

Adults

Initial dose is 5 mg once daily, taken in the morning. May be increased to a maximum of 15 mg once daily if needed and tolerated.

Elderly

No specific dose adjustment is required based solely on age; however, renal function should be assessed before initiation and periodically thereafter.

Renal_impairment

Not recommended for patients with an eGFR <30 mL/min/1.73m². Dosage adjustment may be needed for eGFR 30-<60 mL/min/1.73m².

How to Take

Oral administration, once daily, preferably in the morning, with or without food.

Mechanism of Action

Ertugliflozin inhibits sodium-glucose co-transporter 2 (SGLT2) in the renal tubules, reducing glucose reabsorption and increasing glucose excretion in the urine, thereby lowering blood glucose levels.

Pharmacokinetics

Onset

Glucose-lowering effect typically observed within hours of administration.

Excretion

Approximately 66% excreted in feces and 33% in urine.

Half life

Approximately 11-16 hours.

Absorption

Rapidly absorbed, with peak plasma concentration (Cmax) occurring approximately 1 hour post-dose.

Metabolism

Primarily metabolized via UGT1A9 and UGT2B7 pathways.

Side Effects

Contraindications

Severe renal impairment, end-stage renal disease, or dialysis.
Hypersensitivity to ertugliflozin or any component of the formulation.

Drug Interactions

Lithium

SGLT2 inhibitors may decrease serum lithium levels.

Diuretics

May increase the risk of dehydration and hypotension.

Insulin or Insulin Secretagogues

Increased risk of hypoglycemia when used concomitantly; dose adjustment may be necessary.

Storage

Store below 30°C (86°F) in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Overdose management should involve symptomatic and supportive treatment. Ertugliflozin is minimally dialyzable.

Pregnancy & Lactation

Not recommended during the second and third trimesters of pregnancy. Not recommended during breastfeeding; consider discontinuing breastfeeding or the drug.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets30 tablets

Shelf Life

Typically 24-36 months from manufacturing date.

Availability

Pharmacies, hospitals

Approval Status

FDA Approved

Patent Status

Patent Protected

Clinical Trials

Ertugliflozin has been extensively studied in clinical trials to evaluate its efficacy and safety in glycemic control and cardiovascular outcomes in patients with type 2 diabetes.

Lab Monitoring

Renal function (eGFR) before initiation and periodically.
Glycemic control (HbA1c, fasting plasma glucose).
Lipid profile.

Doctor Notes

Assess renal function (eGFR) before initiating ertugliflozin and periodically thereafter.
Counsel patients on the signs and symptoms of dehydration, urinary tract infections, and diabetic ketoacidosis.
Consider dose adjustment of concomitant insulin or insulin secretagogues to minimize hypoglycemia risk.

Patient Guidelines

Drink adequate fluids to prevent dehydration.
Monitor for symptoms of urinary tract or genital infections and seek medical attention if they occur.
Report any symptoms of ketoacidosis (e.g., nausea, vomiting, abdominal pain, breathlessness, confusion) immediately.

Missed Dose Advice

If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a missed one.

Driving Precautions

Ertugliflozin generally does not directly impair driving ability. However, hypoglycemia (especially when used with insulin or sulfonylureas) or symptoms like dizziness may affect concentration and reaction time.