Medicine Information

Eteen

Name: Eteen
Brand: Eteen
Rating: 4.5 (117 reviews)

Tablet10 mgAntihypertensiveATC: C08CA01

Generic Name

Amlodipine

Manufacturer

Example Pharma Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
eteen 10 mg tablet	৳ 7.00	৳ 70.00

Description

Overview of the medicine

Amlodipine is a calcium channel blocker used to treat high blood pressure (hypertension) and chest pain (angina). It works by relaxing blood vessels, which makes it easier for the heart to pump blood and reduces the workload on the heart.

Uses & Indications

Hypertension (high blood pressure)

Chronic stable angina

Vasospastic angina (Prinzmetal's angina)

Dosage

Adults

Initial dose 5 mg once daily, maximum 10 mg once daily. For hypertension, usual maintenance dose is 5-10 mg once daily. For angina, 5-10 mg once daily.

Elderly

Initial dose 2.5 mg once daily, gradually increase if needed, considering potential lower clearance.

Renal_impairment

No dosage adjustment needed. Amlodipine is not dialyzable.

How to Take

Take orally once daily, with or without food. It is recommended to take it at the same time each day.

Mechanism of Action

Amlodipine is a dihydropyridine calcium antagonist that inhibits the transmembrane influx of calcium ions into cardiac and vascular smooth muscle. This reduces peripheral vascular resistance and lowers blood pressure. It also dilates coronary arteries and arterioles, increasing myocardial oxygen supply in angina.

Pharmacokinetics

Onset

1-2 hours for antihypertensive effect.

Excretion

Excreted predominantly as inactive metabolites in urine (approx. 60%) and feces (approx. 25%).

Half life

30-50 hours.

Absorption

Well absorbed orally, peak plasma concentrations in 6-12 hours. Bioavailability 64-90%.

Metabolism

Extensive hepatic metabolism to inactive metabolites.

Side Effects

Contraindications

Known hypersensitivity to dihydropyridines (e.g., amlodipine) or any component of the formulation
Cardiogenic shock
Severe aortic stenosis
Unstable angina or acute myocardial infarction (within the first 28 days)

Drug Interactions

Simvastatin

Amlodipine may increase simvastatin exposure; limit simvastatin dose to 20 mg/day.

Other Antihypertensives

Concurrent use may result in additive hypotensive effects.

CYP3A4 Inducers (e.g., rifampicin, St. John's Wort)

May decrease amlodipine plasma concentrations, potentially reducing efficacy. Dosage adjustment may be needed.

CYP3A4 Inhibitors (e.g., ketoconazole, clarithromycin, ritonavir)

May increase amlodipine plasma concentrations, leading to increased hypotensive effect. Close monitoring is recommended.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms include excessive peripheral vasodilation with marked hypotension and reflex tachycardia. Treatment involves symptomatic support, including monitoring of cardiac and respiratory function, elevation of extremities, and administration of vasopressors and intravenous fluids if necessary.

Pregnancy & Lactation

Pregnancy Category C. Use only if potential benefit justifies potential risk to fetus. Small amounts excreted in breast milk, caution advised. Consult doctor before use during pregnancy or lactation.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 mg x 10 tablets10 mg x 30 tablets

Shelf Life

24 months from the date of manufacture when stored under recommended conditions.

Availability

Pharmacies, hospitals

Approval Status

Approved by major regulatory bodies (e.g., FDA, EMA, DGDA)

Patent Status

Generic available, original patent expired

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have established amlodipine's efficacy and safety for the treatment of hypertension and angina pectoris in various patient populations.

Lab Monitoring

Regular blood pressure monitoring is essential.
Liver function tests (LFTs) should be considered in patients with hepatic impairment or if symptoms suggest liver dysfunction.
Electrolyte levels may be monitored, especially in patients on diuretics.

Doctor Notes

Monitor blood pressure regularly, especially during initial therapy and dose titration.
Advise patients on the importance of adherence to medication and lifestyle modifications.
Caution in patients with severe hepatic impairment; a lower starting dose (2.5 mg) is recommended for such patients.
Educate patients on potential side effects like ankle edema and advise them when to seek medical attention.

Patient Guidelines

Take Eteen (Amlodipine) exactly as prescribed by your doctor, preferably at the same time each day.
Do not stop taking the medicine without consulting your doctor, even if you feel better.
Inform your doctor about all other medications, supplements, and herbal products you are taking.
Report any unusual or severe side effects to your doctor immediately.
Avoid sudden discontinuation to prevent rebound hypertension.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it's close to the next dose (within 10-12 hours), skip the missed dose and resume your regular schedule. Do not double the dose.

Driving Precautions

Eteen (Amlodipine) may cause dizziness, fatigue, or drowsiness, especially at the start of treatment or when increasing dosage. Avoid driving or operating machinery until you know how this medicine affects you.

Lifestyle Advice

Maintain a healthy diet low in sodium and saturated fats.
Engage in regular physical activity as advised by your doctor.
Avoid smoking and excessive alcohol consumption, as these can worsen blood pressure.
Manage stress through relaxation techniques.