Exiben
Generic Name
Ibandronic Acid
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| exiben 100 mg suspension | ৳ 145.00 | N/A |
Description
Overview of the medicine
Exiben 100 mg Suspension contains Ibandronic Acid, a bisphosphonate medication used to prevent and treat osteoporosis. It works by slowing down bone loss and increasing bone density, reducing the risk of fractures.
Uses & Indications
Dosage
Adults
For osteoporosis, the typical oral dose of ibandronic acid is 150 mg once a month. For a 100 mg suspension, specific dosing would be determined by a physician. If used daily, 100 mg could be considered. Administer at least 60 minutes before the first food or drink of the day (except plain water).
Elderly
No specific dose adjustment is required for elderly patients based on age alone, but renal function should be considered.
Renal_impairment
For creatinine clearance >30 mL/min, no dosage adjustment is needed. For creatinine clearance ≤30 mL/min, use is generally not recommended or requires careful medical assessment.
How to Take
Take orally, at least 60 minutes before the first food, drink (other than plain water), or other medication of the day. Do not lie down for at least 60 minutes after taking the dose.
Mechanism of Action
Ibandronic acid inhibits osteoclast-mediated bone resorption. It binds to hydroxyapatite crystals in the bone matrix and is taken up by osteoclasts. Inside osteoclasts, it disrupts their normal function, leading to decreased bone breakdown.
Pharmacokinetics
Onset
Bone turnover markers begin to decrease within a few days, full effect on BMD takes months.
Excretion
Approximately 50% of the absorbed dose is excreted renally; the unabsorbed portion is excreted in feces.
Half life
Terminal half-life is variable, approximately 10-72 hours, but effectively much longer due to bone binding.
Absorption
Oral absorption is low, typically less than 10%. Absorption is reduced by food and beverages (except plain water).
Metabolism
Not metabolized in humans; excreted unchanged.
Side Effects
Contraindications
- Hypocalcemia
- Inability to stand or sit upright for at least 60 minutes
- Hypersensitivity to ibandronic acid or any excipients
- Severe renal impairment (creatinine clearance ≤ 30 mL/min)
- Esophageal abnormalities which delay esophageal emptying (e.g., stricture or achalasia)
Drug Interactions
NSAIDs
Increased risk of gastrointestinal irritation.
Other Oral Medications
Administer Exiben 100 mg Suspension separately to avoid absorption interference.
Proton Pump Inhibitors (PPIs)
May reduce the efficacy of bisphosphonates (controversial, monitor BMD).
Calcium-containing products & Antacids
May interfere with absorption. Take Exiben 100 mg Suspension at least 60 minutes before.
Storage
Store below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Overdose can lead to hypocalcemia, hypophosphatemia, and upper gastrointestinal adverse events (e.g., esophageal injury, heartburn, esophagitis). Manage symptomatically, provide milk or antacids to bind ibandronic acid.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk. It is unknown whether ibandronic acid is excreted in human milk. Exercise caution when administering to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months when stored as recommended.
Availability
Pharmacies, hospitals
Approval Status
Approved (for Ibandronic Acid formulations)
Patent Status
Generic available
Clinical Trials
Ibandronic acid has undergone extensive clinical trials demonstrating its efficacy in increasing BMD and reducing fracture risk in postmenopausal osteoporosis.
Lab Monitoring
- Serum calcium and phosphate levels (especially before and during treatment)
- Renal function (creatinine clearance)
- Bone mineral density (BMD) using DXA scan (periodically)
Doctor Notes
- Educate patients on proper administration technique to minimize esophageal adverse events.
- Monitor calcium and vitamin D levels, and supplement if necessary.
- Advise patients to report any new thigh, hip, or groin pain immediately.
- Consider drug holidays for long-term users based on individual risk assessment.
Patient Guidelines
- Take with a full glass of plain water (180-240 mL).
- Do not chew, crush, or suck the suspension.
- Remain upright (sitting or standing) for at least 60 minutes after taking the dose.
- Do not eat, drink (other than plain water), or take other medicines for at least 60 minutes after your dose.
Missed Dose Advice
If a monthly dose is missed, and the next scheduled dose is more than 7 days away, take one Exiben 100 mg Suspension in the morning. Then return to your original schedule. If the next scheduled dose is less than 7 days away, skip the missed dose and wait for your next regularly scheduled dose.
Driving Precautions
Generally, Exiben is not expected to affect the ability to drive or operate machinery. However, if side effects like dizziness occur, avoid such activities.
Lifestyle Advice
- Ensure adequate calcium and Vitamin D intake through diet or supplements.
- Engage in weight-bearing exercises.
- Avoid smoking and excessive alcohol consumption.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
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