Medicine Information

Facticin

Name: Facticin
Brand: Facticin
Rating: 4.5 (117 reviews)

Tablet320 mgAntibioticsATC: J01XA01

Generic Name

Fosfomycin

Manufacturer

Hypothetical Pharma Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
facticin 320 mg tablet	৳ 65.19	৳ 391.14

Description

Overview of the medicine

Facticin 320 mg tablet contains Fosfomycin, an antibiotic used to treat various bacterial infections, primarily uncomplicated urinary tract infections (UTIs) in women and other susceptible infections.

Uses & Indications

Uncomplicated urinary tract infections (acute cystitis) in women caused by susceptible strains of E. coli and E. faecalis.

Prophylaxis for transrectal prostate biopsy (off-label use for oral fosfomycin).

Other bacterial infections sensitive to fosfomycin, as determined by susceptibility testing.

Dosage

Adults

For uncomplicated urinary tract infections (acute cystitis): typically a single 3 g dose (often provided in sachet form). For a 320 mg tablet, the specific regimen should be followed as prescribed by a physician, potentially involving multiple doses for 3-7 days for certain infections or as part of a regimen if the 320mg is a specific salt/prodrug.

Elderly

Similar to adult dosage, but caution is advised in elderly patients, especially those with impaired renal function. Dosage adjustment may be necessary.

Renal_impairment

Dosage adjustment is required for patients with creatinine clearance less than 80 mL/min. Not recommended for severe renal impairment (CrCl < 10 mL/min).

How to Take

Facticin 320 mg tablet should be taken orally. It can be taken with or without food. Ensure adequate fluid intake during treatment. If a single dose is prescribed (e.g., 3g sachet), it should be dissolved in water and consumed immediately.

Mechanism of Action

Fosfomycin works by inhibiting bacterial cell wall synthesis at an early stage, specifically by inactivating the enzyme UDP-N-acetylglucosamine-3-enolpyruvyltransferase (MurA), which is crucial for peptidoglycan biosynthesis. This leads to the destruction of the bacterial cell wall.

Pharmacokinetics

Onset

Peak plasma concentrations are typically reached within 2-4 hours after oral administration.

Excretion

Primarily excreted unchanged in the urine (about 80-90% of the dose), with some fecal excretion.

Half life

The elimination half-life is approximately 4-8 hours in individuals with normal renal function.

Absorption

Rapidly absorbed after oral administration. Bioavailability is approximately 30-60%. Absorption may be delayed by food.

Metabolism

Fosfomycin is not significantly metabolized in the body. It is excreted mainly as unchanged drug.

Side Effects

Contraindications

Hypersensitivity to fosfomycin or any other components of the formulation.
Patients with severe renal impairment (creatinine clearance < 10 mL/min) or undergoing hemodialysis.
History of severe diarrhea or colitis associated with antibiotic use.

Drug Interactions

Warfarin

Although rare, some reports suggest potential alteration of INR. Monitor INR closely if co-administered.

Metoclopramide

May reduce the plasma concentrations and urinary excretion of fosfomycin, decreasing its efficacy. Concomitant use should be avoided.

Antacids or Calcium Salts

May decrease the absorption of fosfomycin if administered concurrently. Separate administration by at least 2-3 hours.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose may include gastrointestinal disturbances (e.g., diarrhea, nausea), electrolyte imbalances, and sometimes neurological effects. Management is supportive, including gastric lavage to reduce absorption and symptomatic treatment. Hemodialysis can effectively remove fosfomycin from the bloodstream.

Pregnancy & Lactation

Pregnancy Category B. Fosfomycin is generally considered safe for use during pregnancy when clearly needed and the benefits outweigh the risks. It is excreted into breast milk in small amounts; caution is advised when administering to nursing mothers.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 x 10 tablets (10 tablets per box)3 x 10 tablets (30 tablets per box)

Shelf Life

Usually 2-3 years from the date of manufacture. Check the expiry date on the packaging.

Availability

Available in pharmacies and hospitals nationwide

Approval Status

Approved by national regulatory authorities

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Fosfomycin has undergone extensive clinical trials demonstrating its efficacy and safety for treating uncomplicated UTIs and other susceptible bacterial infections. Ongoing research explores its role in multidrug-resistant infections.

Lab Monitoring

Renal function tests (e.g., serum creatinine, creatinine clearance) should be monitored in patients with pre-existing renal impairment or during prolonged therapy.
Liver function tests (e.g., AST, ALT) may be considered if signs of hepatic dysfunction develop.

Doctor Notes

Confirm susceptibility of the pathogen if clinical response is inadequate after 48-72 hours of treatment.
Educate patients on proper hygiene to prevent recurrence of UTIs.
Consider alternative agents for severe or complicated UTIs due to the single-dose nature or specific formulation limitations of fosfomycin.

Patient Guidelines

Complete the entire prescribed course of Facticin, even if your symptoms improve, to prevent recurrence and development of antibiotic resistance.
Maintain adequate hydration throughout the treatment period.
Report any unusual or severe side effects, especially persistent diarrhea or allergic reactions, to your doctor immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Fosfomycin may cause dizziness. Patients should be advised to exercise caution when driving or operating machinery until they know how the medication affects them.

Lifestyle Advice

For recurrent UTIs, maintain good personal hygiene, especially after bowel movements and before/after sexual activity.
Drink plenty of water to help flush bacteria from the urinary tract.
Avoid irritants like perfumed feminine products.