Feel
Generic Name
Escitalopram Oxalate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| feel 5 mg tablet | ৳ 15.00 | ৳ 60.00 |
Description
Overview of the medicine
Feel 5 mg Tablet is an antidepressant medicine belonging to the Selective Serotonin Reuptake Inhibitor (SSRI) class. It is primarily used to treat depression, anxiety disorders, and panic disorder by increasing the level of serotonin in the brain, which helps to improve mood and reduce symptoms.
Uses & Indications
Dosage
Adults
Initial: 10 mg once daily, may be increased to 20 mg/day after at least one week based on response. For 5 mg tablet, it's typically a starting dose or for maintenance.
Elderly
Initial: 5 mg once daily. Max 10 mg/day.
Renal_impairment
No dosage adjustment needed for mild to moderate impairment. Use with caution in severe impairment.
How to Take
Take orally once daily, with or without food. Swallow the tablet whole with water. Do not crush or chew.
Mechanism of Action
Escitalopram selectively inhibits the reuptake of serotonin (5-HT) in the central nervous system (CNS), leading to an increased concentration of serotonin in the synaptic cleft. This potentiation of serotonergic neurotransmission is thought to be responsible for its antidepressant and anxiolytic effects.
Pharmacokinetics
Onset
Antidepressant effects typically observed within 2-4 weeks.
Excretion
Mainly via urine (metabolites) and feces.
Half life
Approximately 27-32 hours.
Absorption
Well absorbed orally, bioavailability approx 80%.
Metabolism
Primarily hepatic metabolism via CYP2C19, CYP3A4, and CYP2D6 to active and inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to escitalopram or citalopram
- Concomitant use with MAOIs (Monoamine Oxidase Inhibitors) or within 14 days of stopping an MAOI
- Concomitant use with pimozide
- Congenital long QT syndrome or acquired long QT syndrome
Drug Interactions
MAOIs
Increased risk of serotonin syndrome (hyperthermia, rigidity, myoclonus, autonomic instability).
Alcohol
Enhances CNS depressant effects.
Pimozide
Increased pimozide levels and risk of QT prolongation.
NSAIDs/Aspirin/Warfarin
Increased risk of bleeding.
Serotonergic drugs (e.g., Triptans, Tramadol, St. John's Wort)
Increased risk of serotonin syndrome.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms include dizziness, tremor, agitation, somnolence, coma, nausea, vomiting, tachycardia, hypotension, and QT prolongation. Management involves supportive care, maintaining airway, oxygenation, and ventilation. Gastric lavage and activated charcoal may be considered. No specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as escitalopram is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Pharmacies, hospitals, clinics
Approval Status
FDA Approved, DGDA Registered
Patent Status
Patent expired (Generic available)
Clinical Trials
Extensive clinical trials have demonstrated escitalopram's efficacy and safety in the treatment of MDD, GAD, PD, SAD, and OCD. Studies show superior efficacy to placebo and comparable efficacy to other SSRIs and SNRIs.
Lab Monitoring
- Monitor for electrolyte imbalances (especially sodium) if hyponatremia is suspected.
- Monitor liver function tests periodically in patients with hepatic impairment.
Doctor Notes
- Advise patients about the delayed onset of therapeutic effects and the importance of continued treatment.
- Counsel on potential sexual side effects and strategies for management.
- Warn about serotonin syndrome risk when co-administered with other serotonergic agents.
- Monitor for signs of clinical worsening or suicidality, particularly at the start of treatment or after dose changes.
Patient Guidelines
- Do not stop taking this medicine abruptly without consulting your doctor, as it can cause withdrawal symptoms.
- It may take several weeks to feel the full effects of the medicine.
- Avoid alcohol while taking this medicine.
- Report any unusual mood changes or suicidal thoughts to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
This medicine may cause dizziness, drowsiness, or blurred vision. Avoid driving or operating machinery until you know how it affects you.
Lifestyle Advice
- Combine medication with psychotherapy for best results.
- Maintain a balanced diet and regular exercise.
- Ensure adequate sleep.
- Practice stress-reduction techniques like meditation or yoga.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
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