Medicine Information

Feva-Plus

Name: Feva-Plus
Brand: Feva-Plus
Rating: 4.5 (117 reviews)

Tablet500 mgAnalgesics, AntipyreticsATC: N02BE01

Generic Name

Paracetamol 500 mg

Manufacturer

Square Pharmaceuticals Ltd. (assumed)

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
feva plus 500 mg tablet	৳ 2.50	৳ 25.00

Description

Overview of the medicine

Feva-Plus 500 mg Tablet is used to relieve mild to moderate pain and reduce fever. It contains Paracetamol (Acetaminophen) as its active ingredient.

Uses & Indications

Relief of mild to moderate pain (e.g., headache, muscle aches, toothache, menstrual pain)

Reduction of fever

Symptomatic relief of cold and flu

Dosage

Adults

500 mg to 1000 mg every 4-6 hours as needed, maximum 4000 mg in 24 hours.

Elderly

Same as adult dose, but caution advised for those with hepatic or renal impairment.

Renal_impairment

Adjust dose interval for severe renal impairment. CrCl 10-50 mL/min: 6 hours; CrCl <10 mL/min: 8 hours.

How to Take

Oral. Can be taken with or without food. Do not exceed the recommended dose.

Mechanism of Action

Paracetamol works by inhibiting prostaglandin synthesis, primarily in the central nervous system, which leads to analgesic and antipyretic effects.

Pharmacokinetics

Onset

Pain relief: 30-60 minutes, Fever reduction: within 30 minutes.

Excretion

Mainly excreted in urine as glucuronide and sulfate conjugates. Less than 5% is excreted unchanged.

Half life

1-4 hours, typically 2-3 hours.

Absorption

Rapidly and almost completely absorbed from the gastrointestinal tract.

Metabolism

Extensively metabolized in the liver, primarily via glucuronidation and sulfation. A small portion is metabolized by cytochrome P450 to a toxic intermediate (NAPQI).

Side Effects

Contraindications

Hypersensitivity to paracetamol
Severe hepatic impairment

Drug Interactions

Alcohol

Increased risk of hepatotoxicity.

Warfarin

May increase anticoagulant effect.

Cholestyramine

Decreases paracetamol absorption rate.

Isoniazid, Rifampicin

Increased risk of hepatotoxicity.

Metoclopramide, Domperidone

Increase paracetamol absorption rate.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms include nausea, vomiting, abdominal pain, and liver damage. Seek immediate medical attention. N-acetylcysteine (NAC) is the antidote.

Pregnancy & Lactation

Generally considered safe for use during pregnancy and lactation at recommended doses, but always consult a doctor.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets50 tablets100 tablets

Shelf Life

Typically 2-3 years from manufacturing date.

Availability

Pharmacies, Drugstores

Approval Status

Approved by DGDA (assumed for Bangladesh)

Patent Status

Generic (Patent expired)

WHO Essential Medicine

Yes

Clinical Trials

Extensively studied for efficacy and safety, ongoing post-marketing surveillance.

Lab Monitoring

Liver function tests (in cases of overdose or chronic high dose use)
Renal function tests (in prolonged use with pre-existing renal impairment)

Doctor Notes

Advise patients on maximum daily dose to prevent liver toxicity.
Counsel on avoiding concomitant use of other paracetamol-containing products.
Caution for patients with hepatic or severe renal impairment.

Patient Guidelines

Do not exceed the maximum daily dose.
Avoid taking other paracetamol-containing products simultaneously.
Consult a doctor if symptoms persist for more than a few days.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not double the dose.