Medicine Information

Flubac-DS

Name: Flubac-DS
Brand: Flubac-DS
Rating: 4.5 (117 reviews)

Suspension250 mg/5 mLAntibacterial (beta-lactam)ATC: J01CF05

Generic Name

Flucloxacillin

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
flubac ds 250 mg suspension	৳ 110.42	N/A

Description

Overview of the medicine

Flubac-DS 250 mg Suspension contains Flucloxacillin, a penicillin-group antibiotic used to treat bacterial infections. It is effective against various Gram-positive bacteria, particularly penicillinase-producing staphylococci, commonly causing skin and soft tissue infections, bone and joint infections, and respiratory tract infections.

Uses & Indications

Skin and soft tissue infections (e.g., boils, abscesses, cellulitis, infected wounds)

Bone and joint infections (e.g., osteomyelitis)

Respiratory tract infections (e.g., pneumonia, bronchitis when caused by susceptible organisms)

Ear, nose, and throat infections (e.g., otitis media, sinusitis)

Urinary tract infections (when caused by susceptible organisms)

Dosage

Adults

Oral: 250-500 mg every 6 hours, or as directed by the physician. For severe infections, the dose may be increased.

Elderly

No specific dose adjustment is required unless there is significant renal impairment. Monitor renal function.

Renal_impairment

For severe renal impairment (creatinine clearance < 10 mL/min), the dose should be reduced or the dosing interval extended (e.g., 250 mg every 8 or 12 hours) under medical supervision.

How to Take

Flubac-DS suspension should be taken orally. For optimal absorption, it is best to take the medicine 30-60 minutes before meals. Shake the bottle well before each use to ensure uniform dosage. Use the provided measuring cup or spoon for accurate dosing.

Mechanism of Action

Flucloxacillin exerts its bactericidal action by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which prevents the cross-linking of peptidoglycan polymers, leading to cell lysis and bacterial death. It is resistant to degradation by beta-lactamase enzymes produced by some bacteria.

Pharmacokinetics

Onset

Bactericidal effects typically begin within 1-2 hours of administration.

Excretion

Mainly excreted unchanged in the urine (60-70%) via tubular secretion and glomerular filtration. A small amount is excreted in the bile.

Half life

Approximately 0.5 to 1 hour in individuals with normal renal function.

Absorption

Rapidly absorbed from the gastrointestinal tract, especially when taken on an empty stomach. Peak plasma concentrations are achieved within 1-2 hours.

Metabolism

Partially metabolized in the liver, primarily to inactive metabolites.

Side Effects

Contraindications

Hypersensitivity to flucloxacillin, other penicillins, or any component of the formulation.
History of flucloxacillin-associated jaundice or hepatic dysfunction.

Drug Interactions

Probenecid

Increases and prolongs plasma levels of flucloxacillin by reducing its renal tubular secretion.

Methotrexate

Flucloxacillin may reduce the renal clearance of methotrexate, potentially increasing its toxicity.

Oral Contraceptives

May reduce the effectiveness of oral contraceptives, advising additional barrier methods.

Warfarin and other oral anticoagulants

May alter INR (International Normalized Ratio) and bleeding risk. Close monitoring of INR is recommended.

Storage

Store the dry powder below 30°C in a cool, dry place, protected from direct sunlight and moisture. Keep out of reach of children. After reconstitution, store the suspension in a refrigerator (2-8°C) and do not freeze.

Overdose

In case of an overdose, symptomatic and supportive treatment should be given. Gastric lavage may be considered soon after ingestion. Hemodialysis is not effective in removing flucloxacillin from the blood.

Pregnancy & Lactation

Pregnancy: Flucloxacillin should be used during pregnancy only if clearly needed and after careful consideration of the risks and benefits. Lactation: Flucloxacillin is excreted in breast milk in small amounts. Use with caution in nursing mothers, as it may lead to sensitization or gastrointestinal disturbances in the infant. Consult your doctor.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

60 mL bottle (powder for reconstitution)

Shelf Life

Unopened powder: 24-36 months (refer to specific product packaging). Reconstituted suspension: 7-14 days when stored in a refrigerator (2-8°C).

Availability

Pharmacies nationwide

Approval Status

Approved by DGDA

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Flucloxacillin is a well-established antibiotic with extensive historical clinical trial data demonstrating its efficacy and safety against susceptible bacterial infections. Newer trials focus on specific indications, comparative efficacy, and resistance patterns rather than initial drug approval.

Lab Monitoring

Liver function tests (LFTs) should be monitored, especially during prolonged treatment, in the elderly, or in patients with pre-existing hepatic disease.
Renal function should be monitored in patients receiving high doses or with pre-existing renal impairment.

Doctor Notes

Emphasize the importance of taking flucloxacillin on an empty stomach to optimize absorption.
Counsel patients on completing the full prescribed course to prevent antibiotic resistance and ensure eradication of infection.
Advise monitoring for signs of hepatic dysfunction (jaundice, dark urine, pale stools) especially in elderly patients or those on prolonged therapy.
Be aware of potential drug interactions, particularly with warfarin, and monitor INR closely.

Patient Guidelines

Complete the entire course of medication as prescribed by your doctor, even if symptoms improve.
Do not share this medicine with others, even if they have similar symptoms.
Take the medicine on an empty stomach for better absorption, preferably 30-60 minutes before meals.
Shake the suspension well before each use.

Missed Dose Advice

If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Flubac-DS is generally not expected to affect the ability to drive or operate machinery. However, if you experience dizziness or other side effects that could impair your concentration, avoid these activities.

Lifestyle Advice

Maintain good hydration by drinking plenty of fluids during the course of treatment.
Avoid alcohol consumption as it may exacerbate side effects like nausea or stomach upset.

Alternative Medicines in Bangladesh

Similar medicines available in the market

Floclox (Incepta Pharmaceuticals Ltd.)Flucox (Beximco Pharmaceuticals Ltd.)Flumin (Acme Laboratories Ltd.)

Global Brand Names

International brand names for this medicine

General Pharmaceuticals Ltd.

Tablet200 mg

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