Medicine Information

Flukin

Name: Flukin
Brand: Flukin
Rating: 4.5 (117 reviews)

Capsule500 mgAntifungalATC: J02AC01

Generic Name

Fluconazole 500 mg Capsule

Manufacturer

Beximco Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
flukin 500 mg capsule	৳ 11.00	৳ 44.00

Description

Overview of the medicine

Flukin-500 mg Capsule contains Fluconazole, an antifungal medication used to treat a variety of fungal infections, particularly those caused by Candida species. It is effective for systemic infections, vaginal candidiasis, and other mucosal candidiasis.

Uses & Indications

Treatment of cryptococcal meningitis

Treatment of coccidioidomycosis

Prevention of candidiasis in immunocompromised patients

Treatment of oropharyngeal and esophageal candidiasis

Treatment of vaginal candidiasis (acute or recurrent)

Dosage

Adults

For vaginal candidiasis: Single oral dose of 150 mg. For cryptococcal meningitis: 400 mg on day 1, followed by 200-400 mg once daily for 6-8 weeks. For other systemic candidiasis: 400 mg on day 1, then 200-400 mg once daily. For some severe or resistant infections, higher doses up to 800 mg daily may be used.

Elderly

Dosage should be adjusted based on renal function.

Renal_impairment

Reduced dose required for creatinine clearance < 50 mL/min. For CrCl 21-50 mL/min, 50% of the usual dose. For CrCl < 20 mL/min, 25% of the usual dose, or administer usual dose every 2 days.

How to Take

Flukin-500 mg Capsule should be swallowed whole with water, with or without food. For effective treatment, complete the full course of medication as prescribed by the doctor, even if symptoms improve.

Mechanism of Action

Fluconazole inhibits the fungal cytochrome P450 enzyme 14α-demethylase, which is responsible for the demethylation of lanosterol to ergosterol. Ergosterol is an essential component of the fungal cell membrane; its inhibition leads to increased cell membrane permeability and leakage of cellular contents, ultimately causing fungal cell death.

Pharmacokinetics

Onset

Peak plasma concentrations usually achieved within 1-2 hours after oral administration.

Excretion

Mainly renal, 80% as unchanged drug.

Half life

Approximately 30 hours (range 20-50 hours).

Absorption

Well absorbed orally (over 90%), bioavailability is not affected by food.

Metabolism

Minimally metabolized; primarily unchanged drug excreted.

Side Effects

Contraindications

Hypersensitivity to Fluconazole or other azole antifungals
Co-administration with terfenadine, astemizole, cisapride, pimozide, or quinidine due to risk of QTc prolongation and arrhythmias

Drug Interactions

Rifampin

Decreased fluconazole levels, dose adjustment may be needed.

Warfarin

Increased prothrombin time, monitor INR.

Phenytoin

Increased phenytoin levels, monitor.

Cyclosporine, Tacrolimus, Sirolimus

Increased levels of immunosuppressants, monitor renal function and drug levels.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose may include hallucinations and paranoid behavior. Treatment involves symptomatic and supportive care, with hemodialysis potentially accelerating clearance of Fluconazole.

Pregnancy & Lactation

Pregnancy Category D (single dose for vaginal candidiasis is Category C). Avoid during pregnancy, especially during the first trimester, unless the benefits outweigh the risks. Fluconazole is excreted in breast milk; caution is advised during breastfeeding.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 capsule per pack7 capsules per pack10 capsules per pack

Shelf Life

24-36 months from manufacturing date.

Availability

Pharmacies, hospitals, and clinics

Approval Status

Approved by regulatory authorities worldwide, including FDA and DGDA

Patent Status

Generic available (patent expired)

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have established Fluconazole's efficacy and safety for various fungal infections since its approval. Ongoing research explores its use in emerging resistant strains and new indications.

Lab Monitoring

Liver function tests (ALT, AST, bilirubin) in patients with pre-existing liver disease or during prolonged therapy
Renal function tests (creatinine, BUN) for dose adjustment
Electrolytes (potassium, magnesium) for patients at risk of QTc prolongation

Doctor Notes

Ensure patient is not pregnant before prescribing, especially for high doses.
Monitor liver function periodically during prolonged treatment.
Counsel patients on potential drug interactions, especially with narrow therapeutic index drugs.

Patient Guidelines

Take the medication exactly as prescribed by your doctor.
Do not stop taking Flukin-500 mg Capsule prematurely, even if you feel better, to prevent recurrence of infection.
Report any severe skin rash, yellowing of skin/eyes, or unusual fatigue to your doctor immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Flukin-500 mg Capsule may cause dizziness or seizures in some individuals. If you experience these symptoms, avoid driving or operating machinery until you know how the medication affects you.