Medicine Information

Flupen

Name: Flupen
Brand: Flupen
Rating: 4.5 (117 reviews)

Oral Suspension125 mg/5 mlAntibioticsATC: J01CF05

Generic Name

Flucloxacillin

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
flupen 125 mg suspension	৳ 95.00	N/A

Description

Overview of the medicine

Flupen 125 mg Suspension is an antibiotic from the penicillin group, effective against a wide range of bacterial infections. It is particularly useful against penicillinase-producing staphylococci.

Uses & Indications

Skin and soft tissue infections (e.g., cellulitis, boils, abscesses)

Bone and joint infections (e.g., osteomyelitis)

Respiratory tract infections (e.g., pneumonia, bronchitis)

Ear, nose, and throat infections

Urinary tract infections

Septicaemia

Endocarditis

Dosage

Adults

250-500 mg every 6 hours, usually taken half an hour before meals.

Elderly

No specific dose adjustment is generally required unless renal impairment is present.

Renal_impairment

Dose reduction may be necessary in severe renal impairment (creatinine clearance <10 ml/min). For example, 125-250 mg every 8-12 hours.

How to Take

Shake the bottle well before each use. Administer with the provided measuring spoon or cup. Best taken half an hour before meals on an empty stomach to ensure maximum absorption.

Mechanism of Action

Flucloxacillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death. It is resistant to degradation by beta-lactamase enzymes produced by certain bacteria.

Pharmacokinetics

Onset

Rapid (within 1-2 hours)

Excretion

Primarily excreted unchanged by the kidneys via tubular secretion and glomerular filtration. A small amount is excreted in bile.

Half life

Approximately 0.5-1.5 hours in adults with normal renal function.

Absorption

Well absorbed from the gastrointestinal tract, especially when taken on an empty stomach. Peak plasma concentrations are achieved within 1-2 hours.

Metabolism

Partially metabolized in the liver to inactive metabolites.

Side Effects

Contraindications

Hypersensitivity to penicillin antibiotics
History of flucloxacillin-associated jaundice/hepatic dysfunction
Porphyria

Drug Interactions

Warfarin

May enhance the anticoagulant effect of warfarin, requiring close INR monitoring.

Probenecid

Increases plasma levels and prolongs the half-life of flucloxacillin by reducing renal tubular secretion.

Methotrexate

Increases methotrexate toxicity due to competition for renal tubular secretion.

Storage

Store below 30°C in a dry place, away from light. Keep out of reach of children. Once reconstituted, store in a refrigerator (2-8°C) and discard after 7-14 days.

Overdose

Symptoms may include nausea, vomiting, diarrhea, and electrolyte imbalance. Treatment is supportive and symptomatic; gastric lavage or activated charcoal may be considered if recent ingestion. Hemodialysis is not effective.

Pregnancy & Lactation

Pregnancy Category B. Flucloxacillin is generally considered safe during pregnancy. Small amounts are excreted in breast milk; generally considered compatible with breastfeeding, but monitor for rash or diarrhea in the infant.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

60 ml suspension100 ml suspension

Shelf Life

Typically 24-36 months for unopened bottles. Once reconstituted, typically 7-14 days when stored in a refrigerator.

Availability

Pharmacies

Approval Status

Approved

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical use has established its efficacy and safety. Specific trials for new indications or formulations may be ongoing.

Lab Monitoring

Liver function tests (especially with prolonged use or in patients with pre-existing hepatic impairment)
Renal function tests (in patients with pre-existing renal impairment)
Complete blood count (rarely, in prolonged high-dose therapy)

Doctor Notes

Emphasize taking on an empty stomach for optimal absorption.
Caution patients about completing the full course to prevent antibiotic resistance.
Monitor liver function tests in patients with pre-existing hepatic disease or prolonged therapy.

Patient Guidelines

Complete the full course of antibiotics, even if symptoms improve, to prevent resistance.
Take on an empty stomach, 30-60 minutes before meals.
Shake the suspension well before each use.
Do not store leftover medicine; discard after the recommended period (usually 7-14 days after reconstitution).

Missed Dose Advice

If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not double the dose to catch up.

Driving Precautions

Generally, flucloxacillin does not affect the ability to drive or operate machinery. However, if you experience dizziness or other side effects that impair concentration, avoid these activities.

Lifestyle Advice

Maintain good hygiene to prevent reinfection.
Drink plenty of fluids unless advised otherwise by your doctor.
Avoid alcohol consumption during treatment if experiencing side effects like nausea or dizziness.