Medicine Information

Frusin

Name: Frusin
Brand: Frusin
Rating: 4.5 (117 reviews)

Syrup20 mg/5 mLDiuretics, Loop DiureticsATC: C03CA01

Generic Name

Furosemide

Manufacturer

Beximco Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
frusin 20 mg syrup	৳ 85.32	N/A

Description

Overview of the medicine

Furosemide is a potent loop diuretic used to treat edema (fluid retention) associated with congestive heart failure, liver cirrhosis, and renal disease. It is also used to manage hypertension.

Uses & Indications

Edema associated with congestive heart failure, liver cirrhosis, and renal disease (including nephrotic syndrome)

Hypertension (alone or in combination with other antihypertensive agents)

Dosage

Adults

Edema: Initial 20-80 mg as a single dose, adjusted based on response. Hypertension: 20-40 mg twice daily.

Elderly

Lower initial doses and gradual titration, as they may be more susceptible to adverse effects.

Renal_impairment

Dosage adjustment required. In severe renal impairment, higher doses may be needed, but with caution to avoid ototoxicity.

How to Take

Frusin syrup is for oral administration. It can be taken with or without food. To minimize the chance of nighttime urination, take the last dose several hours before bedtime.

Mechanism of Action

Furosemide acts primarily on the thick ascending limb of the loop of Henle, inhibiting the reabsorption of sodium and chloride ions. This leads to increased excretion of water, sodium, chloride, potassium, and hydrogen ions, resulting in diuresis.

Pharmacokinetics

Onset

Oral: 30-60 minutes.

Excretion

Mainly by renal excretion (60-80% as unchanged drug) and some biliary excretion.

Half life

1-1.5 hours in healthy individuals, can be prolonged in renal impairment.

Absorption

Rapidly and almost completely absorbed from the gastrointestinal tract following oral administration. Bioavailability is approximately 50-70%.

Metabolism

Primarily hepatic, with some renal metabolism. It undergoes glucuronidation.

Side Effects

Contraindications

Anuria (absence of urine production)
Hepatic coma and pre-coma states
Severe electrolyte depletion (e.g., severe hypokalemia, hyponatremia)
Hypersensitivity to furosemide or sulfonamides

Drug Interactions

Digoxin

Increased risk of digoxin toxicity due to furosemide-induced hypokalemia.

Lithium

Furosemide may decrease renal excretion of lithium, leading to increased lithium levels and toxicity.

Antihypertensive agents

Potentiation of antihypertensive effect; dose adjustment may be required.

Aminoglycoside antibiotics

Increased risk of ototoxicity.

NSAIDs (Nonsteroidal Anti-inflammatory Drugs)

May reduce the diuretic and antihypertensive effects of furosemide.

Storage

Store below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include dehydration, electrolyte imbalance (hypokalemia, hyponatremia, hypochloremia), hypotension, and gastrointestinal disturbances. Management involves symptomatic treatment, fluid and electrolyte replacement, and monitoring of vital signs.

Pregnancy & Lactation

Pregnancy Category C. Furosemide should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in human breast milk; therefore, discretion should be used when administering to nursing mothers. Consider discontinuing the drug or nursing.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

60 mL syrup bottle100 mL syrup bottle

Shelf Life

Usually 24 to 36 months from the date of manufacture.

Availability

Pharmacies, Hospitals

Approval Status

Approved

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Furosemide has been extensively studied in clinical trials since its introduction, demonstrating efficacy and safety for the treatment of edema and hypertension across various patient populations.

Lab Monitoring

Serum electrolytes (potassium, sodium, chloride, magnesium)
Renal function (BUN, serum creatinine)
Blood pressure
Fluid balance and body weight

Doctor Notes

Monitor serum electrolytes (especially potassium) and renal function closely during therapy, particularly in elderly patients or those on concomitant medications.
Adjust dosage based on patient's fluid status, renal response, and electrolyte levels.
Advise patients on potential symptoms of electrolyte imbalance and importance of compliance.

Patient Guidelines

Take Frusin syrup exactly as prescribed by your doctor.
Report any symptoms of dehydration or electrolyte imbalance (e.g., severe thirst, dry mouth, muscle weakness, confusion).
Do not stop taking the medicine abruptly without consulting your doctor.
Limit your intake of alcohol while taking this medicine, as it may increase dizziness.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Furosemide may cause dizziness or lightheadedness, especially at the beginning of treatment or when changing dose. Avoid driving or operating machinery until you know how this medicine affects you.

Lifestyle Advice

Maintain a balanced diet and follow any dietary restrictions (e.g., low sodium diet) recommended by your doctor.
Stay adequately hydrated, but avoid excessive fluid intake unless advised by your doctor.

Alternative Medicines in Bangladesh

Similar medicines available in the market

Furosemide Syrup (Square Pharmaceuticals Ltd.)Furocef Syrup (ACI Limited)Frusen Syrup (Beximco Pharmaceuticals Ltd.)Furosid Syrup (Incepta Pharmaceuticals Ltd.)