Medicine Information

Fusidate-H

Name: Fusidate-H
Brand: Fusidate-H
Rating: 4.5 (117 reviews)

CreamFusidic Acid 2% and Hydrocortisone 1%Topical Antibiotic and CorticosteroidATC: D07BC01

Generic Name

Fusidic Acid and Hydrocortisone Cream

Manufacturer

Beximco Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
fusidate h 2 1 cream	৳ 125.00	N/A

Description

Overview of the medicine

Fusidic Acid and Hydrocortisone Cream is a topical preparation combining an antibacterial agent (Fusidic Acid) and a corticosteroid (Hydrocortisone). It is used to treat skin conditions where bacterial infection is present or likely to occur alongside inflammation, such as eczema or dermatitis.

Uses & Indications

Eczema with secondary bacterial infection

Dermatitis with secondary bacterial infection

Impetigo (limited areas)

Infected cuts or abrasions where inflammation is also present

Dosage

Adults

Apply a thin layer to the affected skin area 2-3 times daily. Treatment duration usually for up to two weeks, or as directed by physician. Do not use for more than 7 days unless advised by a doctor.

Elderly

No specific dosage adjustments required for elderly patients, use as per adult dosage.

Renal_impairment

No dosage adjustments required for topical application.

How to Take

For external use only. Wash hands before and after applying the cream. Apply a thin layer gently to the affected area. Avoid contact with eyes, mouth, and other mucous membranes. Do not cover the treated area with occlusive dressings unless advised by a doctor.

Mechanism of Action

Fusidic acid inhibits bacterial protein synthesis by interfering with the translocation step of the elongation factor G (EF-G), thereby preventing the addition of new amino acids to the growing peptide chain. Hydrocortisone is a corticosteroid that reduces inflammation, itching, and redness by suppressing the immune response and inhibiting the release of inflammatory mediators.

Pharmacokinetics

Onset

Anti-inflammatory and antibacterial effects typically begin within a few hours to a day after application.

Excretion

Systemically absorbed fusidic acid is excreted mainly in bile. Systemically absorbed hydrocortisone metabolites are primarily excreted via urine and bile.

Half life

Not directly applicable for topical cream for systemic half-life. Systemic half-life of fusidic acid is ~5-6 hours. Hydrocortisone applied topically has negligible systemic half-life implications.

Absorption

Topical application leads to minimal systemic absorption for both fusidic acid and hydrocortisone, especially when skin is intact. Absorption may increase with broken skin, occlusive dressings, or application to large surface areas.

Metabolism

Fusidic acid is primarily metabolized in the liver, but systemic metabolism is minimal with topical application. Hydrocortisone is metabolized in the liver to inactive metabolites, but again, systemic metabolism is negligible with topical use.

Side Effects

Contraindications

Hypersensitivity to fusidic acid, hydrocortisone, or any excipients
Fungal skin infections (e.g., Athlete's foot, ringworm)
Viral skin infections (e.g., Herpes simplex, chickenpox)
Tuberculous skin infections
Perioral dermatitis
Rosacea
Acne vulgaris
Ulcerated skin areas

Drug Interactions

None significant

Systemic absorption is minimal, so significant drug interactions are unlikely with topical use. However, prolonged or extensive use may theoretically lead to some systemic absorption and potential interactions with drugs metabolized by CYP3A4 for hydrocortisone, but this is rare in practice.

Storage

Store below 30°C. Do not freeze. Keep out of reach of children. Protect from light and moisture.

Overdose

Topical overdose is unlikely to cause serious systemic effects due to minimal absorption. Excessive use may lead to local adverse effects such as skin thinning, stretch marks, or increased risk of local infection. If large amounts are ingested orally, seek medical attention.

Pregnancy & Lactation

Use during pregnancy and lactation should only be considered if the potential benefit outweighs the potential risk to the fetus or infant. Avoid extensive use, large areas, or prolonged periods. Consult a doctor before use.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 gm tube15 gm tube30 gm tube

Shelf Life

24-36 months (unopened), 3 months after opening

Availability

Pharmacies, Hospitals

Approval Status

Approved

Patent Status

Off-patent

Clinical Trials

Numerous clinical trials have established the efficacy and safety of fusidic acid and hydrocortisone in treating infected eczematous dermatitis. Studies typically focus on comparing it with individual components or other combination therapies.

Lab Monitoring

Not typically required for routine topical use.

Doctor Notes

Emphasize limited duration of use (usually max 2 weeks).
Advise against use on viral/fungal infections.
Caution patients about potential skin thinning with prolonged use, especially on face or in children.
Consider bacterial resistance if no improvement.

Patient Guidelines

Complete the full course of treatment even if symptoms improve.
Do not use for longer than recommended by your doctor.
Avoid applying to eyes, mouth, or internal body cavities.
Inform your doctor if your condition does not improve or worsens.

Missed Dose Advice

If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one.