Medicine Information

g-diazepam

Name: g-diazepam
Brand: g-diazepam
Rating: 4.5 (117 reviews)

Injection10 mg/2 mlAnxiolytic, Sedative, Anticonvulsant, Muscle RelaxantATC: N05BA01

Generic Name

Diazepam 10 mg Injection

Manufacturer

Generic Pharma Co.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
g diazepam 10 mg injection	৳ 7.00	N/A

Description

Overview of the medicine

Diazepam is a benzodiazepine derivative that has anxiolytic, anticonvulsant, sedative, skeletal muscle relaxant, and amnestic properties. It is used to treat anxiety disorders, withdrawal symptoms, muscle spasms, and certain types of seizures. The injection form is used for rapid action in acute conditions.

Uses & Indications

Acute anxiety states

Status epilepticus (severe seizures)

Severe recurrent convulsive seizures

Premedication for surgical procedures

Acute alcohol withdrawal syndrome

Skeletal muscle spasm

Dosage

Adults

Adults: For acute anxiety/agitation: 2-10 mg IM or IV, repeated in 3-4 hours if necessary. For status epilepticus: 5-10 mg IV, repeated if necessary at 10-15 minute intervals up to max 30 mg. For muscle spasm: 5-10 mg IM or IV, repeated if necessary.

Elderly

Elderly: Initial dose should be reduced to half of the usual adult dose (e.g., 2.5-5 mg IV/IM), with careful titration based on response.

Renal_impairment

Renal impairment: No specific dose adjustment generally required, but caution is advised. Monitor for excessive sedation.

How to Take

For intravenous (IV) administration, inject slowly into a large vein at a rate not exceeding 5 mg/minute to minimize risk of venous irritation and thrombophlebitis. For intramuscular (IM) administration, inject deeply into a large muscle mass.

Mechanism of Action

Diazepam enhances the effect of gamma-aminobutyric acid (GABA) by binding to the benzodiazepine site on the GABA-A receptor, leading to increased chloride ion influx, hyperpolarization, and reduced neuronal excitability.

Pharmacokinetics

Onset

IV: 1-5 minutes for anxiolytic/sedative effects. IM: 15-30 minutes.

Excretion

Primarily excreted in urine as glucuronide conjugates.

Half life

Parent drug: 20-50 hours. Active metabolite (desmethyldiazepam): 30-100 hours.

Absorption

Rapid and complete absorption after intramuscular (IM) injection, but may be erratic. Rapid after intravenous (IV) injection.

Metabolism

Extensively metabolized in the liver via CYP3A4 and CYP2C19 to active metabolites (desmethyldiazepam, temazepam, oxazepam).

Side Effects

Contraindications

Hypersensitivity to diazepam or other benzodiazepines
Acute narrow-angle glaucoma
Severe respiratory insufficiency
Severe hepatic insufficiency
Myasthenia gravis
Sleep apnea syndrome

Drug Interactions

Alcohol

Increased CNS depression.

Opioids

Increased risk of profound sedation, respiratory depression, coma, and death due to additive CNS depressant effects.

Antacids

Delayed absorption but not reduced.

Phenytoin

May alter phenytoin levels.

Antifungals (e.g., ketoconazole)

Increased diazepam levels due to CYP3A4 inhibition.

Storage

Store at room temperature (below 30°C), protect from light. Do not freeze.

Overdose

Symptoms include somnolence, confusion, diminished reflexes, coma. In severe cases, respiratory depression and hypotension. Treatment is supportive, including airway management, IV fluids, and flumazenil (a benzodiazepine antagonist) as an antidote if severe CNS/respiratory depression is present and not due to mixed overdose.

Pregnancy & Lactation

Pregnancy Category D. May cause fetal harm. Avoid during pregnancy, especially in the first trimester. Excreted in breast milk, avoid during breastfeeding or monitor infant for sedation/feeding difficulties.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

5 ampoules x 2 ml10 ampoules x 2 ml

Shelf Life

Typically 2-3 years from manufacturing date.

Availability

Hospitals, pharmacies, clinics

Approval Status

Approved by major regulatory bodies (e.g., FDA, MHRA, DGDA)

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Extensively studied and widely used for decades. Ongoing research focuses on specific applications and comparative effectiveness.

Lab Monitoring

Liver function tests (for long-term use)
Complete blood count (for long-term use)
Respiratory rate and depth (during acute administration)

Doctor Notes

Caution in patients with respiratory depression or hepatic impairment.
Monitor for signs of dependence during long-term therapy.
Avoid rapid IV injection to prevent hypotension and respiratory arrest.

Patient Guidelines

Do not discontinue abruptly due to withdrawal risk.
Avoid alcohol and other CNS depressants.
Report any unusual side effects to your doctor.
Do not drive or operate heavy machinery until you know how this medicine affects you.

Missed Dose Advice

As this is an injection, administered by a healthcare professional, a missed dose is unlikely in a controlled setting. If administered at home, contact your doctor immediately.

Driving Precautions

This medicine causes drowsiness, dizziness, and impaired coordination. Do not drive, operate machinery, or perform other hazardous activities until you know how this medicine affects you and are sure it does not impair your ability.