Medicine Information

Gabatec

Name: Gabatec
Brand: Gabatec
Rating: 4.5 (117 reviews)

Capsule100 mgAnticonvulsant, Neuropathic Pain AgentATC: N03AX12

Generic Name

Gabapentin

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
gabatec 100 mg capsule	৳ 22.00	৳ 176.00

Description

Overview of the medicine

Gabapentin is an anticonvulsant medicine used to treat partial seizures and neuropathic pain such as postherpetic neuralgia and pain due to diabetic neuropathy.

Uses & Indications

Adjunctive therapy in the treatment of partial seizures with and without secondary generalization in adults and children 3 years and older.

Management of postherpetic neuralgia in adults.

Neuropathic pain due to diabetic neuropathy.

Dosage

Adults

For neuropathic pain: Initially 300 mg once daily on Day 1, 300 mg twice daily on Day 2, and 300 mg three times daily on Day 3. Doses can be further titrated up to 1800-3600 mg/day in divided doses. For partial seizures: Initial dose is 300 mg three times daily, which can be increased based on patient response up to 1800-3600 mg/day in divided doses.

Elderly

Dose adjustment may be necessary due to age-related decline in renal function. Start with a lower dose and titrate cautiously based on clinical response and tolerability.

Renal_impairment

Dose must be reduced in patients with impaired renal function. Dosage should be adjusted based on creatinine clearance. For example, for CrCl 30-59 mL/min, maximum daily dose is 400-800 mg/day.

How to Take

Take the capsule orally with a glass of water, with or without food. Do not chew, crush, or break the capsule. If taking antacids, take Gabatec at least 2 hours after the antacid.

Mechanism of Action

Gabapentin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the brain. This action is thought to reduce the release of excitatory neurotransmitters, thereby decreasing neuronal excitability and controlling pain signals and seizures.

Pharmacokinetics

Onset

Onset of action for pain relief or seizure control can vary, often requiring gradual titration over several days to weeks to achieve full therapeutic effect.

Excretion

It is excreted unchanged by the kidneys. Renal elimination is the sole route of excretion.

Half life

Approximately 5-7 hours in individuals with normal renal function.

Absorption

Gabapentin is absorbed from the gastrointestinal tract via a saturable L-amino acid transport system. Bioavailability is dose-dependent, decreasing with increasing dose.

Metabolism

Gabapentin is not significantly metabolized in humans. It does not induce or inhibit hepatic enzymes.

Side Effects

Contraindications

Hypersensitivity to gabapentin or any component of the formulation.

Drug Interactions

Antacids

Antacids containing aluminum and magnesium can reduce the bioavailability of gabapentin by about 20%. It is recommended to take gabapentin at least 2 hours after antacid administration.

Opioids (e.g., Morphine)

Concomitant use with opioids, especially morphine, can increase gabapentin levels and enhance CNS depressive effects like sedation, somnolence, and respiratory depression.

Alcohol and other CNS depressants

May enhance the sedative effects of gabapentin.

Storage

Store below 25°C in a dry place, protected from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include drowsiness, dizziness, blurred vision, slurred speech, lethargy, and mild diarrhea. Management is primarily supportive. Hemodialysis can be considered in severe cases, especially in patients with renal impairment.

Pregnancy & Lactation

Pregnancy Category C. Gabapentin has shown evidence of developmental toxicity in animals. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Gabapentin is excreted in human milk; caution should be exercised when administered to a nursing woman.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 x 10 capsules

Shelf Life

2-3 years (refer to package for exact date)

Availability

Pharmacies nationwide

Approval Status

Approved by regulatory authorities

Patent Status

Generic available

Clinical Trials

Gabapentin has undergone extensive clinical trials supporting its efficacy and safety in various neurological conditions, including partial seizures and neuropathic pain. Studies have demonstrated its role in reducing seizure frequency and pain intensity.

Lab Monitoring

Routine laboratory monitoring is not typically required for gabapentin. However, renal function should be monitored in patients with pre-existing renal impairment or in elderly patients.
Monitor for any signs of worsening depression, suicidal thoughts, or unusual changes in behavior.

Doctor Notes

Counsel patients on the importance of gradual dose titration and avoiding abrupt discontinuation to minimize withdrawal symptoms and rebound seizures.
Warn about potential CNS side effects such as dizziness, somnolence, and ataxia, especially during initiation of therapy. Advise caution with driving and operating machinery.
Monitor for signs of mood changes, depression, or suicidal ideation, particularly in vulnerable populations.

Patient Guidelines

Do not stop taking Gabatec suddenly, as this may increase the frequency of seizures or withdrawal symptoms. Always consult your doctor before stopping or changing your dose.
Gabatec may cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how the medicine affects you.
Report any unusual mood changes, depression, or suicidal thoughts to your doctor immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Gabatec can cause dizziness, drowsiness, and impaired vision. Patients should be advised not to drive or operate hazardous machinery until they are reasonably certain that Gabatec does not adversely affect their ability to engage in such activities.

Lifestyle Advice

Avoid alcohol consumption while taking Gabatec, as it can worsen drowsiness and dizziness.
Maintain a healthy lifestyle, including a balanced diet and regular exercise, which can support overall well-being.