Medicine Information

Glitab

Name: Glitab
Brand: Glitab
Rating: 4.5 (117 reviews)

Tablet80 mgOral AntidiabeticATC: A10BB09

Generic Name

Gliclazide

Manufacturer

X Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
glitab 80 mg tablet	৳ 4.50	N/A

Description

Overview of the medicine

Gliclazide 80 mg tablet is an oral antidiabetic medication used to lower blood sugar levels in adults with type 2 diabetes mellitus. It helps the pancreas produce more insulin.

Uses & Indications

Treatment of Type 2 Diabetes Mellitus in adults, when diet, physical exercise, and weight reduction alone are not sufficient.

Monotherapy or in combination with other antidiabetic agents.

Dosage

Adults

Initial dose is 40-80 mg daily, taken with breakfast. The dose can be gradually increased to a maximum of 320 mg daily in divided doses, depending on the patient's response.

Elderly

No specific dose adjustment for elderly patients, but careful monitoring is recommended due to potential increased sensitivity to hypoglycemic effects. Start with a low dose and titrate slowly.

Renal_impairment

In mild to moderate renal impairment, the dose may need to be reduced. Close monitoring of blood glucose and renal function is essential. Contraindicated in severe renal impairment.

How to Take

Glitab 80 mg Tablet should be taken orally once daily with breakfast or the first main meal. It should be swallowed whole with water, not crushed or chewed.

Mechanism of Action

Gliclazide stimulates insulin release from the pancreatic β-cells by blocking ATP-sensitive potassium channels, leading to depolarization and calcium influx, which triggers insulin secretion. It also has some extrapancreatic effects and potential antioxidant properties.

Pharmacokinetics

Onset

Onset of action typically within 1-2 hours.

Excretion

Excreted mainly in the urine (60-70%) and feces (10-20%) as metabolites.

Half life

Plasma half-life of approximately 8-20 hours.

Absorption

Rapidly and completely absorbed from the gastrointestinal tract.

Metabolism

Extensively metabolized in the liver, primarily by CYP2C9, to inactive metabolites.

Side Effects

Contraindications

Type 1 Diabetes Mellitus
Diabetic ketoacidosis, diabetic precoma and coma
Severe renal or hepatic insufficiency
Hypersensitivity to gliclazide or other sulfonylureas or any excipients of the product
Pregnancy and lactation
Concomitant treatment with miconazole

Drug Interactions

Alcohol

Increases the hypoglycaemic reaction, which can lead to hypoglycaemic coma.

Phenylbutazone (systemic route)

Increases the hypoglycaemic effect of sulfonylureas, displacing them from protein binding sites and/or reducing their elimination.

Miconazole (systemic route, oral gel)

Increases the hypoglycaemic effect with possible onset of hypoglycaemia or even coma.

Beta-blockers, ACE inhibitors, Fluconazole, H2-receptor antagonists

May potentiate the blood glucose lowering effect, increasing the risk of hypoglycemia.

Storage

Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

An overdose of Gliclazide can lead to severe hypoglycemia, which may manifest as confusion, tremor, sweating, hunger, blurred vision, and potentially coma. Treatment involves immediate administration of glucose (oral if conscious, intravenous if unconscious) and careful monitoring.

Pregnancy & Lactation

Gliclazide is contraindicated during pregnancy and lactation. Insulin is the preferred treatment for diabetes during pregnancy. Breastfeeding is not recommended while taking Gliclazide.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

30 tablets (10x3 blister)100 tablets (10x10 blister)

Shelf Life

Usually 24 to 36 months from the date of manufacture.

Availability

Available in pharmacies and hospitals

Approval Status

Approved by regulatory authorities

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Gliclazide has been extensively studied in numerous clinical trials demonstrating its efficacy and safety in managing Type 2 Diabetes Mellitus. Studies have shown its cardiovascular benefits compared to some other sulfonylureas.

Lab Monitoring

Regular monitoring of blood glucose levels (fasting, postprandial)
Glycated hemoglobin (HbA1c) every 3-6 months
Renal function tests (e.g., serum creatinine, eGFR)
Liver function tests (e.g., ALT, AST)

Doctor Notes

Emphasize patient education regarding hypoglycemia symptoms and management.
Monitor renal and hepatic function, especially in elderly patients.
Consider lifestyle modifications (diet, exercise) as foundational therapy for Type 2 Diabetes Mellitus.
Avoid concomitant use with miconazole due to severe interaction risk.

Patient Guidelines

Take the tablet at the same time each day with a meal, preferably breakfast, to reduce the risk of hypoglycemia.
Do not skip meals and maintain a regular eating pattern.
Recognize and manage symptoms of hypoglycemia (e.g., sweating, trembling, dizziness) by consuming a quick source of sugar.
Regularly monitor blood sugar levels as advised by your doctor.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

Driving Precautions

Patients should be aware of the symptoms of hypoglycemia and exercise caution while driving or operating machinery, especially at the beginning of treatment or after dose adjustments. If hypoglycemic symptoms occur, avoid driving.

Lifestyle Advice

Adhere to a balanced diet recommended for diabetes, limiting sugar and refined carbohydrates.
Engage in regular physical activity as advised by your healthcare provider.
Maintain a healthy weight.
Avoid or limit alcohol consumption.