Gonal-f
Generic Name
Follitropin alfa
Manufacturer
Merck Serono (a division of Merck KGaA, Germany)
Country
Germany
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| gonal f 1050 iu injection | ৳ 39,019.00 | N/A |
Description
Overview of the medicine
Gonal-f is a recombinant human follicle-stimulating hormone (r-hFSH) used in fertility treatments to stimulate follicular development in women undergoing controlled ovarian stimulation and to induce spermatogenesis in men with hypogonadotropic hypogonadism.
Uses & Indications
Dosage
Adults
Dosage is highly individualized and determined by a healthcare professional. For women, typical starting doses range from 75-150 IU daily, adjusted based on ovarian response. For men, typically 150 IU three times weekly, in conjunction with hCG.
Elderly
No specific dosage adjustments are typically required for elderly patients, but caution is advised. Limited data available.
Renal_impairment
No specific studies in renal impairment. Use with caution and consider individual patient factors.
How to Take
Administered by subcutaneous injection, usually in the abdomen or thigh. Patients may be taught self-administration after proper training.
Mechanism of Action
Follitropin alfa binds to FSH receptors on ovarian granulosa cells in women and Sertoli cells in men, stimulating follicular growth and maturation in women, and inducing spermatogenesis in men.
Pharmacokinetics
Onset
Therapeutic effects are observed over several days to weeks of treatment.
Excretion
Excreted mainly via the kidneys, with a smaller proportion in the bile.
Half life
Approximately 24-48 hours.
Absorption
Subcutaneous bioavailability is approximately 70%. Peak serum concentrations occur 6-24 hours post-administration.
Metabolism
Primarily metabolized in the liver and kidneys.
Side Effects
Contraindications
- Primary ovarian failure (elevated FSH levels).
- Primary testicular failure.
- Uncontrolled non-gonadal endocrinopathies (e.g., thyroid, adrenal, pituitary disorders).
- Sex hormone-dependent tumors of the reproductive organs or breast.
- Abnormal uterine bleeding of undetermined origin.
- Ovarian cysts or enlargement not due to polycystic ovarian disease (PCOD).
- Pregnancy or lactation.
- Hypersensitivity to the active substance or any excipients.
Drug Interactions
Clomiphene citrate
Concurrent use may potentiate the follicular response, requiring lower Gonal-f doses.
GnRH agonists/antagonists
May require higher doses of Gonal-f to achieve the desired ovarian response.
Storage
Store in a refrigerator (2°C to 8°C). Do not freeze. After first use, can be stored for up to 28 days at or below 25°C.
Overdose
The effects of an overdose are unknown, but it may lead to ovarian hyperstimulation syndrome (OHSS). Management is supportive and symptomatic.
Pregnancy & Lactation
Gonal-f is contraindicated during pregnancy and should not be used by women who are breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years when stored unopened. Check product packaging for exact expiry.
Availability
Available in pharmacies and fertility clinics
Approval Status
FDA approved, widely approved internationally
Patent Status
Patent expired in many regions, generics available
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Gonal-f in controlled ovarian stimulation for ART and in induction of ovulation.
Lab Monitoring
- Serum estradiol levels
- Transvaginal ultrasonography for follicular development
- hCG levels (to confirm pregnancy or as part of male treatment)
Doctor Notes
- Individualize treatment based on patient's ovarian reserve and response.
- Careful monitoring of follicular development and serum estradiol levels is crucial to minimize OHSS risk.
- Counsel patients thoroughly on risks, benefits, and proper administration technique.
Patient Guidelines
- Follow your doctor's instructions for dosage and administration precisely.
- Learn proper injection technique if self-administering.
- Report any severe abdominal pain, bloating, or rapid weight gain immediately, as these could be signs of OHSS.
- Attend all scheduled monitoring appointments.
- Discuss all medications, supplements, and health conditions with your doctor.
Missed Dose Advice
If a dose is missed, contact your doctor or clinic immediately for advice. Do not take a double dose to make up for a missed one.
Driving Precautions
Gonal-f is not expected to affect the ability to drive or operate machinery. However, if side effects such as headache or dizziness occur, avoid such activities.
Lifestyle Advice
- Maintain a healthy diet and lifestyle.
- Avoid alcohol and smoking during treatment.
- Follow any specific dietary or activity recommendations from your fertility specialist.
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