Halonate
Generic Name
Halobetasol Propionate 0.05% Ointment
Manufacturer
Generic Pharma Inc.
Country
Bangladesh
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Price Details
Current market pricing information
Variant | Unit Price | Strip Price |
---|---|---|
halonate 005 ointment | ৳ 130.00 | N/A |
Description
Overview of the medicine
Halobetasol Propionate 0.05% Ointment is a high-potency topical corticosteroid indicated for the relief of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
Uses & Indications
Dosage
Adults
Apply a thin layer to the affected skin area once or twice daily for up to 2 consecutive weeks. Do not use for longer than 2 weeks.
Elderly
No specific dosage adjustments required; use with caution due to thinner skin and increased potential for systemic absorption.
Renal_impairment
No specific dosage adjustment guidance for topical use.
How to Take
For external use only. Apply a thin film to the affected skin area and massage gently until the medicine disappears. Wash hands before and after application.
Mechanism of Action
Halobetasol Propionate, a synthetic corticosteroid, exerts its therapeutic effects by its anti-inflammatory, antipruritic, and vasoconstrictive actions. It induces phospholipase A2 inhibitory proteins, thereby controlling the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.
Pharmacokinetics
Onset
Within hours to days of application.
Excretion
Excreted by the kidneys, with some biliary excretion.
Half life
Not well-established for topical application; systemic half-life of corticosteroids generally varies.
Absorption
Systemic absorption of topical corticosteroids varies. Factors influencing absorption include the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings. Absorption is higher on damaged skin and in areas like the face, groin, and axillae.
Metabolism
Primarily metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to halobetasol propionate or any component of the formulation
- Viral (e.g., herpes simplex, varicella) and fungal infections of the skin
- Rosacea
- Perioral dermatitis
- Acne vulgaris
Drug Interactions
Not significant for topical use
Systemic drug interactions are unlikely with appropriate topical use due to minimal systemic absorption. However, caution should be exercised if other systemic corticosteroids are being used concurrently.
Storage
Store below 30°C. Do not freeze. Protect from light and moisture. Keep out of reach of children.
Overdose
Excessive or prolonged use of topical corticosteroids can suppress the hypothalamic-pituitary-adrenal (HPA) axis, leading to secondary adrenal insufficiency. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Avoid extensive use, large areas, or prolonged periods. Exercise caution when administered to a nursing woman; consider potential systemic absorption.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by FDA/DGDA
Patent Status
Off-patent
Clinical Trials
Clinical trials have demonstrated the efficacy and safety of Halobetasol Propionate 0.05% Ointment in treating corticosteroid-responsive dermatoses, including psoriasis and eczema, typically showing significant improvement within 2 weeks.
Lab Monitoring
- Periodical evaluation for HPA axis suppression (e.g., ACTH stimulation test, plasma cortisol levels) if applied over large surface areas or for prolonged periods, especially in children.
Doctor Notes
- Emphasize short-term use (maximum 2 weeks) for optimal efficacy and minimal side effects.
- Educate patients on proper application technique and warning signs of systemic absorption.
- Consider alternative, less potent steroids for sensitive areas or maintenance therapy.
Patient Guidelines
- Use only as directed by your doctor. Do not use for longer than 2 consecutive weeks.
- Avoid contact with eyes, mouth, and other mucous membranes.
- Do not apply to the face, groin, or axillae unless specifically directed by a doctor.
- Do not cover the treated area with an occlusive dressing (e.g., plastic wrap) unless instructed by a doctor.
- Inform your doctor if your condition does not improve within 2 weeks or worsens.
Missed Dose Advice
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not apply a double dose to make up for a missed one.
Driving Precautions
Halonate-005-Ointment is a topical medication and is not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- Keep the affected skin area clean and dry.
- Avoid harsh soaps or irritants on the treated skin.
- Wear loose-fitting clothing to avoid irritation.
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Global Brand Names
International brand names for this medicine
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