Medicine Information

Injefer

Name: Injefer
Brand: Injefer
Rating: 4.5 (117 reviews)

Injection100 mg (of elemental iron)Anti-anemic preparations, Iron preparationsATC: B03AC02

Generic Name

Iron Sucrose

Manufacturer

Acme Laboratories Ltd. (example)

Country

Bangladesh (example)

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
injefer 100 mg injection	৳ 400.00	N/A

Description

Overview of the medicine

Iron Sucrose Injection is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with chronic kidney disease (CKD), including those on dialysis and not on dialysis, where oral iron is ineffective or not tolerated.

Uses & Indications

Iron deficiency anemia in patients with Chronic Kidney Disease (CKD) on hemodialysis.

Iron deficiency anemia in patients with CKD not on dialysis.

Iron deficiency anemia in patients with CKD on peritoneal dialysis.

Dosage

Adults

Generally, 100-200 mg elemental iron, administered 1 to 3 times per week, for a total cumulative dose of 1000 mg over several sessions. Administered as a slow intravenous injection or diluted infusion.

Elderly

Similar to adults, but with careful monitoring due to potential comorbidities.

Renal_impairment

Primary indication; dosage as described for adults, adjusted based on iron status and tolerance.

How to Take

Administer by slow intravenous injection (e.g., 100 mg over at least 2 to 5 minutes) or by infusion (diluted in 100 mL of 0.9% NaCl and infused over at least 15 minutes). Patient should be observed for adverse reactions during and after administration.

Mechanism of Action

Iron sucrose is a complex of polynuclear iron (III)-hydroxide in sucrose. After intravenous administration, the complex is taken up by the reticuloendothelial system, where iron is released and incorporated into transferrin, ferritin, and hemosiderin, eventually becoming available for erythropoiesis.

Pharmacokinetics

Onset

Rapid distribution, but clinical effect (increase in Hb) takes several weeks.

Excretion

Minimal renal excretion. The iron is primarily stored in the reticuloendothelial system or utilized for erythropoiesis.

Half life

Total iron half-life of approximately 3-4 hours.

Absorption

Administered intravenously, hence 100% bioavailable.

Metabolism

Iron dissociates from the sucrose complex; iron is then transported to the bone marrow and incorporated into hemoglobin.

Side Effects

Contraindications

Known hypersensitivity to iron sucrose or any of its components.
Anemia not caused by iron deficiency.
Evidence of iron overload (e.g., hemochromatosis, hemosiderosis).

Drug Interactions

Oral Iron Preparations

Reduced absorption of oral iron if given concomitantly. Do not administer oral iron until at least 5 days after the last iron sucrose injection.

Storage

Store below 30°C. Do not freeze. Protect from light. Keep out of reach of children.

Overdose

Overdose may lead to acute iron overload, which can manifest as hypotension, circulatory collapse, and potentially severe organ damage. Management includes discontinuing iron sucrose and, if severe, administering iron chelating agents (e.g., deferoxamine).

Pregnancy & Lactation

Pregnancy Category B. Studies in pregnant animals have shown no evidence of harm to the fetus. However, use in humans only if clearly needed. Caution should be exercised when administered to a nursing woman.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 x 5 mL vial5 x 5 mL vials

Shelf Life

Typically 2-3 years from manufacturing date, refer to package insert.

Availability

Available in hospitals and pharmacies

Approval Status

Approved by regulatory authorities (e.g., FDA, DGDA)

Patent Status

Generic available, patents expired

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have demonstrated the efficacy and safety of iron sucrose in treating iron deficiency anemia in CKD patients, leading to improved hemoglobin levels and iron stores.

Lab Monitoring

Hemoglobin (Hb) and Hematocrit (Hct) levels
Serum Ferritin
Transferrin Saturation (TSAT)

Doctor Notes

Always observe the patient for signs of hypersensitivity reactions for at least 30 minutes after each administration.
Administer slowly to minimize the risk of hypotension.
Monitor iron parameters regularly to guide subsequent dosing.

Patient Guidelines

Report any unusual symptoms or allergic reactions immediately to your healthcare provider.
Ensure you attend all scheduled appointments for injection and monitoring.
Do not take oral iron supplements unless advised by your doctor.

Missed Dose Advice

If a dose is missed, contact your doctor or nurse to reschedule. Do not double the dose to catch up.

Driving Precautions

May cause dizziness or lightheadedness, especially after initial doses. Patients should be cautioned against driving or operating machinery until they know how the medication affects them.

Lifestyle Advice

Maintain a balanced diet rich in iron-rich foods, where appropriate.
Follow your doctor's recommendations for managing your underlying chronic kidney disease.