Medicine Information

Inpen

Name: Inpen
Brand: Inpen
Rating: 4.5 (117 reviews)

Injection (Powder for solution)500 mgCarbapenem antibioticATC: J01DH02

Generic Name

Meropenem

Manufacturer

Reputable Generic Pharmaceutical Co.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
inpen 500 mg injection	৳ 700.00	N/A

Description

Overview of the medicine

Inpen 500 mg Injection contains Meropenem, a broad-spectrum carbapenem antibiotic used to treat a wide range of serious bacterial infections, including pneumonia, urinary tract infections, intra-abdominal infections, skin and soft tissue infections, and meningitis.

Uses & Indications

Complicated skin and skin structure infections

Complicated intra-abdominal infections

Bacterial meningitis

Pneumonia (including hospital-acquired pneumonia and ventilator-associated pneumonia)

Complicated urinary tract infections

Febrile neutropenia (empiric therapy)

Sepsis

Dosage

Adults

Usual dose is 500 mg to 1 g intravenously every 8 hours, depending on the type and severity of infection.

Elderly

Dose adjustment may be necessary based on renal function.

Renal_impairment

Dose reduction required; e.g., CrCl 26-50 mL/min: 1 adult unit every 12 hours; CrCl 10-25 mL/min: 1/2 adult unit every 12 hours; CrCl <10 mL/min: 1/2 adult unit every 24 hours.

How to Take

For intravenous use only. Administer as an intravenous bolus over 3-5 minutes or as an intravenous infusion over 15-30 minutes. Reconstitution instructions must be followed carefully.

Mechanism of Action

Meropenem is a bactericidal antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.

Pharmacokinetics

Onset

Rapid, typically within minutes of IV administration.

Excretion

Primarily excreted unchanged in the urine (approximately 70% within 12 hours).

Half life

Approximately 1 hour in adults with normal renal function.

Absorption

Rapid and almost complete absorption after intravenous administration.

Metabolism

Minimal hepatic metabolism; primarily hydrolyzed by dehydropeptidase-I (DHP-I) in the kidneys, but Meropenem is stable to DHP-I.

Side Effects

Contraindications

Known hypersensitivity to meropenem, carbapenem antibiotics, or any component of the formulation.
Patients with a history of severe hypersensitivity reactions to other beta-lactam antibiotics (e.g., penicillins, cephalosporins).

Drug Interactions

Probenecid

Probenecid competes with meropenem for active tubular secretion, leading to increased plasma concentrations and prolonged half-life of meropenem.

Valproic acid

Concomitant use with Meropenem may result in significant reduction in valproic acid plasma concentrations, increasing the risk of seizure.

Oral anticoagulants (e.g., Warfarin)

Increased anticoagulant effect has been reported when carbapenems are co-administered with warfarin, leading to an increased risk of bleeding.

Storage

Store dry powder below 25°C (77°F), protected from light. Reconstituted solution should be used immediately or stored as per manufacturer's guidelines.

Overdose

In the event of an overdose, discontinue Meropenem and initiate general supportive treatment. Hemodialysis can remove meropenem and its metabolite from the body.

Pregnancy & Lactation

Pregnancy Category B. Use in pregnancy only if clearly needed. Meropenem is excreted in human milk; caution should be exercised when administered to a nursing woman.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 vial of 500 mg Meropenem

Shelf Life

Typically 2-3 years, check product label for specific expiry.

Availability

Hospitals and pharmacies

Approval Status

Approved (Generic)

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Meropenem has undergone extensive clinical trials demonstrating its efficacy and safety across a broad range of severe bacterial infections in both adults and pediatric populations.

Lab Monitoring

Monitor renal function (creatinine, BUN) regularly, especially in patients with pre-existing renal impairment.
Monitor liver function tests (ALT, AST, ALP) periodically.
Complete blood count (CBC) should be monitored during prolonged therapy.

Doctor Notes

Meropenem is a critical antibiotic for treating severe, multidrug-resistant bacterial infections.
Careful consideration of renal function is essential for dose adjustment, especially in elderly and renally impaired patients.
Monitor for seizure activity, particularly in patients with CNS disorders or compromised renal function.

Patient Guidelines

Complete the full course of treatment, even if symptoms improve, to prevent recurrence and development of antibiotic resistance.
Report any severe side effects immediately to your healthcare provider.
Inform your doctor about all other medications you are taking.

Missed Dose Advice

If a dose is missed, administer it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.

Driving Precautions

This medicine may cause dizziness or seizures in some patients. Patients should be advised to exercise caution when driving or operating machinery.

Lifestyle Advice

Maintain good hydration during treatment.
Avoid alcohol consumption while on Meropenem.
Practice good hygiene to prevent further infections.

Alternative Medicines in Bangladesh

Similar medicines available in the market

Meronem (AstraZeneca)Meropen (Renata Limited)Merostar (Square Pharmaceuticals Ltd.)Meropem (Beximco Pharmaceuticals Ltd.)

Global Brand Names

International brand names for this medicine

Square Pharmaceuticals Ltd.

Tablet500 mg

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