Medicine Information

Insulet

Name: Insulet
Brand: Insulet
Rating: 4.5 (117 reviews)

Subcutaneous Injection100 Units/mL (50% Insulin Lispro Protamine Suspension & 50% Insulin Lispro Injection)AntidiabeticATC: A10AD04

Generic Name

Insulin Lispro Protamine Suspension & Insulin Lispro Injection

Manufacturer

Eli Lilly and Company

Country

USA

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
insulet 50 50 injection	৳ 169.70	N/A

Description

Overview of the medicine

Insulet-50-50-injection is a pre-mixed insulin formulation containing 50% insulin lispro protamine suspension and 50% insulin lispro injection. It is used to improve glycemic control in patients with diabetes mellitus.

Uses & Indications

Improve glycemic control in adults and children with diabetes mellitus.

Dosage

Adults

Individualized dosage based on metabolic needs, blood glucose monitoring, and glycemic control goals. Typically administered subcutaneously, 15 minutes before or immediately after a meal.

Elderly

Close monitoring of blood glucose required; dosage adjustments may be necessary due to potential renal/hepatic impairment and increased sensitivity to insulin.

Renal_impairment

Dosage may need to be reduced in patients with renal impairment due to decreased insulin clearance.

How to Take

Administer subcutaneously in the abdominal wall, thigh, upper arm, or buttock. Rotate injection sites to reduce the risk of lipodystrophy. Do not administer intravenously or intramuscularly.

Mechanism of Action

Insulin, including insulin lispro, lowers blood glucose by stimulating peripheral glucose uptake by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulin inhibits lipolysis and proteolysis, and enhances protein synthesis.

Pharmacokinetics

Onset

15-30 minutes (due to lispro component)

Excretion

Excreted primarily by the kidneys.

Half life

Variable, depends on dose and injection site. Functional half-life for glucose lowering effect can be longer.

Absorption

Rapid absorption of lispro, slower absorption of protamine suspension from subcutaneous tissue.

Metabolism

Metabolized in the liver and kidneys.

Side Effects

Contraindications

During episodes of hypoglycemia.
In patients with hypersensitivity to insulin lispro or any of the excipients.

Drug Interactions

Beta-blockers

May mask the symptoms of hypoglycemia.

Oral Antidiabetic Agents

May require dosage adjustments of both agents.

ACE Inhibitors, Salicylates, Sulfonamides

May enhance the hypoglycemic effect of insulin.

Thiazide Diuretics, Corticosteroids, Thyroid Hormones

May decrease the hypoglycemic effect of insulin.

Storage

Store unopened vials/cartridges in a refrigerator (2°C-8°C / 36°F-46°F). Do not freeze. Protect from light. Once opened or in-use, store at room temperature (below 30°C / 86°F) for up to 28 days.

Overdose

Overdose may lead to severe hypoglycemia, which can be treated by oral glucose or glucagon injection. Severe cases may require intravenous glucose.

Pregnancy & Lactation

Insulin requirements may change during pregnancy and lactation. Close monitoring and dosage adjustments are essential. Generally considered safe for use during pregnancy, but consult a healthcare provider.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

5 x 3 mL cartridges1 x 10 mL vial

Shelf Life

Unopened: 2 years from manufacture date when refrigerated. Opened/In-use: 28 days at room temperature (below 30°C/86°F).

Availability

Pharmacies, Hospitals

Approval Status

Approved by FDA

Patent Status

Patent Expired (for generic insulin lispro combinations)

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have demonstrated the efficacy and safety of insulin lispro 50/50 mix in improving glycemic control in both Type 1 and Type 2 diabetes.

Lab Monitoring

Fasting Plasma Glucose (FPG)
Postprandial Glucose
HbA1c
Serum Potassium (periodically)

Doctor Notes

Emphasize the importance of consistent meal timing and carbohydrate counting.
Educate patients on proper injection technique and rotation of sites to prevent lipodystrophy.
Counsel patients on recognizing and treating hypoglycemia.

Patient Guidelines

Always check the insulin label before each injection.
Learn proper injection technique and rotate injection sites.
Monitor blood glucose levels regularly as advised by your doctor.
Be aware of symptoms of hypoglycemia and how to treat it.

Missed Dose Advice

If a dose is missed, blood glucose should be checked, and a healthcare professional should be consulted. Do not take a double dose to compensate for a missed dose.

Driving Precautions

Patients should be advised to take precautions to avoid hypoglycemia while driving, especially if they experience recurrent hypoglycemia or have reduced or absent warning symptoms of hypoglycemia.