Medicine Information

Intravas

Name: Intravas
Brand: Intravas
Rating: 4.5 (117 reviews)

Solution for Injection (Prefilled Syringe)6000 anti-Xa IU/0.6 mLAnticoagulantsATC: B01AB06

Generic Name

Nadroparin Calcium

Manufacturer

Hypothetical Pharma Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
intravas 6000 anti xa injection	৳ 600.00	N/A

Description

Overview of the medicine

Nadroparin Calcium is a low molecular weight heparin (LMWH) used to prevent and treat blood clots (thrombosis). It works by inhibiting Factor Xa, an enzyme critical in the blood clotting cascade.

Uses & Indications

Prophylaxis of venous thromboembolic disease (VTE), particularly in surgical patients.

Treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE).

Prevention of clotting in the extracorporeal circulation during hemodialysis.

Treatment of unstable angina and non-ST-segment elevation myocardial infarction (NSTEMI).

Dosage

Adults

Dosage varies by indication and patient weight. For DVT prophylaxis, typical doses range from 2850 to 5700 anti-Xa IU once daily. For DVT/PE treatment, doses can be 85 anti-Xa IU/kg twice daily or 171 anti-Xa IU/kg once daily.

Elderly

No specific dose adjustment for elderly patients with normal renal function, but caution is advised due to potential age-related decline in renal function.

Renal_impairment

Dose adjustment or avoidance is required in severe renal impairment (creatinine clearance <30 mL/min). Monitoring of anti-Xa levels may be necessary.

How to Take

Administer by subcutaneous injection into the abdominal wall, usually alternately on the left and right sides. Do not inject intramuscularly. Follow aseptic technique. Do not mix with other injections.

Mechanism of Action

Nadroparin potentiates the action of antithrombin III, leading to the inactivation of Factor Xa. It has a high anti-Xa activity and a lower anti-IIa (antithrombin) activity compared to unfractionated heparin, resulting in a more predictable anticoagulant response.

Pharmacokinetics

Onset

Within hours following subcutaneous administration.

Excretion

Primarily renally excreted as unchanged drug and metabolites.

Half life

Approximately 3-4 hours for anti-Xa activity after subcutaneous administration.

Absorption

Rapidly and almost completely absorbed after subcutaneous injection. Peak anti-Xa activity occurs 3-5 hours post-dose.

Metabolism

Partially desulfated and depolymerized in the liver and kidneys.

Side Effects

Contraindications

Active major bleeding or conditions predisposing to severe bleeding (e.g., hemorrhagic stroke, active gastric ulcer).
History of Heparin-Induced Thrombocytopenia (HIT) with or without thrombosis.
Severe uncontrolled hypertension.
Hypersensitivity to nadroparin or other heparins/LMWHs.

Drug Interactions

Thrombolytic agents

Greatly increased risk of hemorrhage.

Other Anticoagulants (e.g., Warfarin, Dabigatran)

Potentiated anticoagulant effect, significantly increased bleeding risk.

NSAIDs and Antiplatelet agents (e.g., Aspirin, Clopidogrel)

Increased risk of bleeding. Use with caution.

Storage

Store below 25-30°C. Do not freeze. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms include bleeding. Management involves discontinuing the drug. Protamine sulfate can partially neutralize the anti-Xa activity, but it does not fully reverse the effect of LMWHs.

Pregnancy & Lactation

Pregnancy Category B/C. Use during pregnancy only if clearly needed after careful assessment of benefits and risks. Excretion into breast milk is minimal, but caution is advised in nursing mothers.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

2 prefilled syringes5 prefilled syringes10 prefilled syringes

Shelf Life

Typically 2-3 years when stored under recommended conditions.

Availability

Pharmacies, Hospitals

Approval Status

Approved

Patent Status

Off-patent, Generic available

WHO Essential Medicine

Yes

Clinical Trials

Nadroparin, as an LMWH, has undergone extensive clinical trials demonstrating its efficacy and safety in various indications, particularly in the prevention and treatment of venous thromboembolism.

Lab Monitoring

Complete Blood Count (CBC) including platelet count (before treatment and regularly thereafter to detect HIT).
Renal function tests (creatinine clearance).
Anti-Xa levels (may be useful in obese patients, renal impairment, pregnancy, or in cases of suspected overdose).

Doctor Notes

Monitor for signs of bleeding, particularly in patients with renal impairment, low body weight, or concomitant use of other anticoagulants/antiplatelets.
Check platelet count regularly to screen for Heparin-Induced Thrombocytopenia (HIT).
Dose adjustment is crucial in patients with severe renal impairment. Consider anti-Xa level monitoring in specific high-risk populations.

Patient Guidelines

Follow proper subcutaneous injection technique as instructed by your healthcare provider.
Report any signs of unusual bleeding or bruising immediately.
Inform all healthcare professionals (including dentists) that you are taking this medication.
Do not take aspirin, NSAIDs, or other blood thinners unless approved by your doctor.

Missed Dose Advice

If a dose is missed, take it as soon as you remember, unless it is almost time for your next scheduled dose. Do not double the dose to catch up.

Driving Precautions

Nadroparin is not expected to affect the ability to drive or operate machinery. However, if you experience dizziness or other symptoms of bleeding, exercise caution.

Lifestyle Advice

Avoid activities that may increase your risk of bleeding or injury.
Maintain good hydration and follow a balanced diet.

Alternative Medicines in Bangladesh

Similar medicines available in the market

Enoxaparin (e.g., Clexane, Enox) - Sanofi, InceptaDalteparin (e.g., Fragmin) - Pfizer

Global Brand Names

International brand names for this medicine

Acme Laboratories Ltd.

TabletParacetamol 500 mg + Caffeine 65 mg

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