Ivertin
Generic Name
Ivermectin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ivertin 6 mg tablet | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Ivermectin is an antiparasitic medication used to treat certain parasitic infections, including onchocerciasis (river blindness), strongyloidiasis, lymphatic filariasis, and scabies. It works by paralyzing and killing the parasites.
Uses & Indications
Dosage
Adults
Onchocerciasis: 0.15 mg/kg as a single oral dose, repeated every 3-12 months. Strongyloidiasis: 0.2 mg/kg as a single oral dose. Scabies: 0.2 mg/kg as a single oral dose, repeated in 7-14 days if needed. Other parasitic infections: Dosage varies, typically 0.2 mg/kg single dose or daily for a few days.
Elderly
No specific dose adjustment generally needed, but monitor for adverse effects.
Renal_impairment
No specific dose adjustment recommended, as it is primarily excreted in feces.
How to Take
Oral. Take with a glass of water, preferably on an empty stomach (e.g., 1 hour before a meal) for optimal absorption, though can be taken with food to reduce GI upset.
Mechanism of Action
Ivermectin binds selectively and with high affinity to glutamate-gated chloride ion channels which are present in invertebrate nerve and muscle cells. This binding leads to an increase in the permeability of the cell membrane to chloride ions, causing hyperpolarization of the nerve or muscle cell, and results in paralysis and death of the parasite.
Pharmacokinetics
Onset
Clinical effect often seen within days to weeks depending on the infection.
Excretion
Primarily excreted in feces (approximately 99%), with less than 1% excreted in urine.
Half life
Approximately 12-36 hours.
Absorption
Well absorbed orally, peak plasma concentrations reached in about 4-5 hours. Absorption is enhanced with a fatty meal.
Metabolism
Extensively metabolized in the liver, primarily by CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to ivermectin or any component of the tablet.
- Patients with impaired blood-brain barrier (e.g., meningitis, head trauma).
- Children weighing less than 15 kg.
Drug Interactions
Warfarin
May increase INR, monitor closely.
CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
May increase ivermectin plasma levels.
Other GABAergic drugs (e.g., benzodiazepines, barbiturates)
May enhance CNS depressant effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include rash, edema, headache, dizziness, asthenia, nausea, vomiting, diarrhea, abdominal pain, seizures, coma. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Excreted in breast milk, so advise caution or temporary discontinuation of breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years (check specific product packaging)
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Ongoing research for various indications, including COVID-19 (though not officially approved for it by major agencies). Established efficacy for approved parasitic infections.
Lab Monitoring
- Periodical stool examinations for strongyloidiasis to confirm eradication.
- Liver function tests if there are signs of hepatic impairment.
Doctor Notes
- Verify diagnosis with appropriate lab tests (e.g., stool ova and parasite, skin scraping).
- Educate patients on proper hygiene and contact precautions for parasitic infections.
- Monitor for systemic side effects, especially in patients with co-morbidities.
Patient Guidelines
- Complete the full course of treatment as prescribed.
- Report any severe side effects or allergic reactions immediately.
- Do not share the medication with others.
- Keep out of reach of children.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness, drowsiness, or visual disturbances. Patients should be cautioned about operating machinery or driving until they know how the medication affects them.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection, especially for scabies and intestinal parasites.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
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