Medicine Information

Ketorin

Name: Ketorin
Brand: Ketorin
Rating: 4.5 (117 reviews)

Tablet10 mgNSAIDs (Non-Steroidal Anti-Inflammatory Drugs)ATC: M01AB15

Generic Name

Ketorolac Tromethamine

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
ketorin 10 mg tablet	৳ 10.07	৳ 100.70

Description

Overview of the medicine

Ketorin 10 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) primarily used for the short-term management of moderate to severe acute pain. It works by reducing hormones that cause inflammation and pain in the body.

Uses & Indications

Short-term management of moderate to severe acute pain

Post-operative pain

Musculoskeletal pain

Renal colic (off-label)

Dosage

Adults

10 mg every 4-6 hours as needed, not to exceed 40 mg per day. Treatment duration should not exceed 5 days.

Elderly

Reduced dosage may be necessary due to potential for impaired renal function. Max 20 mg/day.

Renal_impairment

Contraindicated in advanced renal impairment. For mild impairment, dosage reduction is required; max 10 mg/day.

How to Take

For oral use. Can be taken with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water.

Mechanism of Action

Ketorolac inhibits prostaglandin synthesis by blocking cyclooxygenase (COX-1 and COX-2) enzymes. This reduces the formation of prostaglandins, which are mediators of pain, inflammation, and fever.

Pharmacokinetics

Onset

Analgesic effect typically begins within 30-60 minutes.

Excretion

Primarily excreted in the urine (about 91%) and feces (about 6%).

Half life

Approximately 5-6 hours in healthy adults.

Absorption

Rapidly and completely absorbed orally. Peak plasma concentrations are reached within 30-60 minutes after oral administration.

Metabolism

Extensively metabolized in the liver, primarily via glucuronidation.

Side Effects

Contraindications

Hypersensitivity to ketorolac or other NSAIDs
Active peptic ulcer, GI bleeding or perforation
Advanced renal impairment
Coagulopathy or patients at high risk of bleeding
As prophylactic analgesic before major surgery
During labor and delivery
Children under 16 years

Drug Interactions

Lithium

Increased lithium plasma levels, potentially leading to toxicity.

Methotrexate

Increased methotrexate toxicity.

ACE Inhibitors/ARBs

Increased risk of renal impairment, especially in elderly or volume-depleted patients.

Other NSAIDs/Aspirin

Increased risk of GI adverse effects.

Diuretics (e.g., Furosemide)

Reduced natriuretic effect, potential for renal impairment.

Anticoagulants (e.g., Warfarin)

Increased risk of bleeding.

Storage

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves symptomatic and supportive care. Gastric lavage or activated charcoal may be considered if recent ingestion.

Pregnancy & Lactation

Not recommended during pregnancy, especially in the third trimester due to risk of premature closure of the fetal ductus arteriosus. Use with caution during lactation; small amounts may pass into breast milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per box30 tablets per box

Shelf Life

3 years from the date of manufacture.

Availability

Pharmacies, Hospitals

Approval Status

Approved by FDA and DGDA

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have demonstrated ketorolac's efficacy in managing acute pain, often showing comparable or superior analgesia to opioids for moderate pain, with a favorable safety profile when used short-term.

Lab Monitoring

Renal function (BUN, creatinine)
Liver function (ALT, AST)
Complete blood count (CBC) if long-term use (not recommended for ketorolac)
Stool for occult blood if GI symptoms occur

Doctor Notes

Emphasize short-term use (max 5 days) due to significant GI and CV risks.
Assess renal function prior to and during treatment, especially in elderly or compromised patients.
Concomitant use with other NSAIDs or anticoagulants is generally contraindicated.
Educate patients on symptoms of GI bleeding and stroke/MI.

Patient Guidelines

Take exactly as prescribed, for the shortest duration possible.
Do not exceed the recommended dose or duration of treatment (max 5 days).
Report any signs of GI bleeding (black, tarry stools; coffee-ground vomit).
Avoid alcohol while taking this medicine.
Inform your doctor about all other medications you are taking.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

May cause dizziness, drowsiness, or visual disturbances. Patients should be advised not to drive or operate machinery if they experience these effects.

Lifestyle Advice

Avoid activities that require alertness if experiencing drowsiness or dizziness.
Maintain good hydration.
Avoid smoking, as it can worsen GI side effects.