Medicine Information

L-Sol

Name: L-Sol
Brand: L-Sol
Rating: 4.5 (117 reviews)

Tablet2 mgProkinetic Agent, AntipsychoticATC: N05AL07

Generic Name

Levosulpiride

Manufacturer

Reputable Pharmaceutical Co.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
l sol 2 mg tablet	৳ 1.50	৳ 15.00

Description

Overview of the medicine

L-Sol 2 mg Tablet contains Levosulpiride, which is primarily used to treat functional dyspepsia, irritable bowel syndrome (IBS) with predominant dyspepsia, and anxiety or depression with somatic symptoms. It acts as a prokinetic agent and also has mild antipsychotic properties.

Uses & Indications

Functional dyspepsia (non-ulcer dyspepsia)

Irritable Bowel Syndrome (IBS) with predominant dyspepsia

Anxiety and depression with somatic symptoms

Dosage

Adults

The usual recommended dose is 25 mg three times daily. For L-Sol 2 mg, a lower dose might be prescribed for specific conditions, typically 2 mg three times daily, or as directed by the physician.

Elderly

A lower initial dose may be considered due to potential reduced renal function. Dosage should be individualized based on response and tolerability.

Renal_impairment

Dosage adjustment is necessary. For mild to moderate impairment, the dose may be reduced to half. For severe impairment, it may be contraindicated or require significant reduction and careful monitoring.

How to Take

Take the tablet orally with water, with or without food. It is generally recommended to take it before meals for better prokinetic effect.

Mechanism of Action

Levosulpiride is a selective antagonist of peripheral and central D2-dopaminergic receptors. Its prokinetic action is primarily due to antagonism of pre-synaptic D2 receptors in the enteric nervous system, leading to increased acetylcholine release and enhanced gastrointestinal motility. At higher doses, it also blocks post-synaptic D2 receptors in the limbic system, contributing to its mood-modulating and anxiolytic effects.

Pharmacokinetics

Onset

Clinical effects on gastric motility typically begin within 30-60 minutes.

Excretion

Mainly excreted by the kidneys (approximately 90% as unchanged drug) within 24 hours.

Half life

Approximately 6-8 hours, with some inter-individual variability.

Absorption

Rapidly absorbed after oral administration, with peak plasma concentrations reached within 1-3 hours.

Metabolism

Undergoes minimal hepatic metabolism. Excretion primarily occurs unchanged.

Side Effects

Contraindications

Hypersensitivity to Levosulpiride or any component of the formulation.
Pheochromocytoma.
Epilepsy or manic states.
Prolactin-dependent tumors (e.g., pituitary prolactinoma, breast cancer).
Gastrointestinal hemorrhage, mechanical obstruction, or perforation where stimulation of gastrointestinal motility could be harmful.

Drug Interactions

Levodopa

Levosulpiride may antagonize the effects of levodopa.

CNS Depressants

Concurrent use may enhance CNS depression (e.g., drowsiness, sedation).

Anticholinergics

May antagonize the prokinetic effect of Levosulpiride.

Drugs prolonging QT interval

Caution advised as Levosulpiride may prolong QT interval (though rare at low doses).

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose may include drowsiness, sedation, extrapyramidal symptoms, and hypotension. Treatment is symptomatic and supportive, including gastric lavage and activated charcoal if appropriate. ECG monitoring may be necessary.

Pregnancy & Lactation

Not recommended during pregnancy, especially during the first trimester, unless clearly necessary and potential benefits outweigh the risks. Avoid during lactation as Levosulpiride is excreted in breast milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 Tablets (Blister Pack)30 Tablets (Blister Pack)

Shelf Life

24 months from the date of manufacture when stored under recommended conditions.

Availability

Pharmacies nationwide

Approval Status

Approved

Patent Status

Generic

Clinical Trials

Extensive clinical trials have demonstrated Levosulpiride's efficacy in improving symptoms of functional dyspepsia and IBS, as well as its tolerability profile. Further research is ongoing for other potential applications.

Lab Monitoring

Prolactin levels (especially with long-term use or endocrine symptoms)
Renal function (in patients with kidney impairment)

Doctor Notes

Consider baseline prolactin levels before initiating long-term therapy.
Educate patients about potential endocrine side effects and advise them to report any changes.
Monitor for extrapyramidal symptoms, particularly in sensitive patients or with dose escalation.
Use with caution in patients with a history of cardiovascular disease due to potential QT prolongation risk.

Patient Guidelines

Do not exceed the prescribed dose without consulting your doctor.
Inform your doctor about all other medications, including over-the-counter drugs and herbal supplements.
Avoid consumption of alcohol while taking this medicine as it may increase drowsiness.
If you experience unusual symptoms, contact your physician immediately.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

L-Sol 2 mg may cause drowsiness or dizziness. Avoid driving or operating heavy machinery until you know how the medicine affects you.

Lifestyle Advice

Maintain a balanced diet and regular meal schedule to help manage gastrointestinal symptoms.
Regular, moderate exercise can also aid in digestive health.