Medicine Information

Lacticon

Name: Lacticon
Brand: Lacticon
Rating: 4.5 (117 reviews)

Powder for Oral Solution10 gmLaxativesATC: A06AD11

Generic Name

Lactulose 10 gm powder

Manufacturer

Reputed Pharmaceutical Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
lacticon 10 gm powder	৳ 25.00	N/A

Description

Overview of the medicine

Lacticon 10 gm powder contains Lactulose, an osmotic laxative used to treat constipation and hepatic encephalopathy by increasing water content and softening stools, or by reducing ammonia absorption.

Uses & Indications

Chronic constipation

Hepatic encephalopathy

Bowel evacuation prior to colonoscopy or other procedures

Dosage

Adults

For constipation: 10-20 gm daily as a single dose or in two divided doses. For hepatic encephalopathy: 20-30 gm three to four times daily, adjusted to achieve 2-3 soft stools per day.

Elderly

Same as adult dosage, but may require careful titration.

Renal_impairment

No specific dose adjustment needed as it is minimally absorbed and renally excreted.

How to Take

Dissolve the contents of one sachet in half a glass of water and drink immediately. Can be taken with or without food. Ensure adequate fluid intake.

Mechanism of Action

Lactulose is metabolized by colonic bacteria into low molecular weight organic acids, which increase the osmotic pressure in the colon, drawing water into the lumen. This softens the stool and increases its bulk, promoting peristalsis. In hepatic encephalopathy, it lowers colonic pH, which favors the conversion of ammonia (NH3) to ammonium (NH4+), which is then trapped in the colon and excreted.

Pharmacokinetics

Onset

24-48 hours for laxative effect; 24 hours to several days for hepatic encephalopathy

Excretion

Excreted unchanged in feces; absorbed portion excreted in urine.

Half life

Undefined for systemic circulation due to minimal absorption; largely dependent on colonic transit time.

Absorption

Minimally absorbed (less than 3%)

Metabolism

Not metabolized by human enzymes; metabolized by colonic bacteria.

Side Effects

Contraindications

Galactosemia
Intestinal obstruction
Perforation of the gastrointestinal tract
Hypersensitivity to lactulose

Drug Interactions

Antacids

May inhibit the action of lactulose by altering colonic pH.

Other laxatives

Concurrent use with other laxatives may increase the risk of electrolyte imbalance.

Oral anti-infectives (e.g., neomycin)

May reduce the degradation of lactulose by colonic bacteria, diminishing its effect.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms may include abdominal pain, diarrhea, and electrolyte disturbances (especially hypokalemia). Treatment involves symptomatic and supportive care, including fluid and electrolyte replacement.

Pregnancy & Lactation

Generally considered safe during pregnancy and lactation as it is minimally absorbed. Consult a doctor before use.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 sachets per box20 sachets per box

Shelf Life

Typically 2-3 years, as specified on the packaging.

Availability

Pharmacies, Hospitals

Approval Status

Approved

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Numerous clinical trials support the efficacy of lactulose for chronic constipation and hepatic encephalopathy.

Lab Monitoring

Electrolyte levels (in patients on high doses or with pre-existing conditions)
Ammonia levels (in hepatic encephalopathy)

Doctor Notes

Advise patients on adequate hydration.
Monitor for electrolyte imbalance in susceptible patients.
Educate patients that initial flatulence is common.

Patient Guidelines

Drink plenty of water while taking this medicine.
Do not use for more than 7 days without consulting a doctor.
Be aware of increased flatulence initially; this usually subsides.
Inform your doctor if constipation persists or worsens.

Missed Dose Advice

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular schedule. Do not double the dose.

Driving Precautions

Generally not expected to affect the ability to drive or operate machinery. However, if experiencing dizziness or significant abdominal discomfort, avoid such activities.