Medicine Information

Letab

Name: Letab
Brand: Letab
Rating: 4.5 (117 reviews)

Tablet500 mgAntibiotic (Fluoroquinolone type)ATC: J01MA23

Generic Name

Letabine 500 mg Tablet

Manufacturer

MediPharma Inc.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
letab 500 mg tablet	৳ 15.00	৳ 150.00

Description

Overview of the medicine

Letab 500 mg Tablet is an antibiotic used to treat a variety of bacterial infections, including those of the respiratory tract, urinary tract, skin, and soft tissues. It contains Letabine, a broad-spectrum fluoroquinolone.

Uses & Indications

Community-acquired pneumonia

Acute bacterial sinusitis

Chronic bronchitis exacerbation

Complicated urinary tract infections

Skin and soft tissue infections

Dosage

Adults

500 mg once daily for 7-14 days, depending on the infection.

Elderly

No specific dose adjustment required based on age, but renal function should be assessed.

Renal_impairment

Reduce dose for creatinine clearance <50 mL/min; e.g., 250 mg once daily.

How to Take

Take orally with or without food. Swallow the tablet whole with a glass of water. Do not crush or chew.

Mechanism of Action

Letabine inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes involved in bacterial DNA replication, transcription, repair, and recombination. This leads to cell death and bacterial eradication.

Pharmacokinetics

Onset

1-2 hours

Excretion

Primarily renal excretion (urine) with a small amount excreted in feces.

Half life

Approximately 6-8 hours

Absorption

Rapidly and well absorbed from the gastrointestinal tract; bioavailability approximately 99%.

Metabolism

Minimally metabolized in the liver; primarily excreted unchanged.

Side Effects

Contraindications

Hypersensitivity to Letabine or other fluoroquinolones
History of tendonitis or tendon rupture associated with fluoroquinolone use
Myasthenia gravis
Children and adolescents (due to risk of cartilage damage)

Drug Interactions

NSAIDs

May increase risk of CNS stimulation and convulsions.

Warfarin

May enhance anticoagulant effects; monitor INR.

Theophylline

May increase theophylline levels and toxicity.

Antacids (containing magnesium, aluminum)

Decrease absorption of Letabine; take Letabine 2 hours before or 6 hours after antacids.

Storage

Store below 30°C in a dry place, away from direct sunlight. Keep out of reach of children.

Overdose

Symptoms may include CNS effects (confusion, tremors, seizures), nausea, vomiting. Treatment is symptomatic and supportive, including gastric lavage and adequate hydration. Hemodialysis is not effective.

Pregnancy & Lactation

Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Excreted in breast milk; avoid breastfeeding or discontinue the drug.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets30 tablets

Shelf Life

36 months from manufacturing date

Availability

Pharmacies, hospitals, clinics

Approval Status

Approved by regulatory authorities

Patent Status

Patent expired

Clinical Trials

Phase III clinical trials demonstrated efficacy against various bacterial infections with a good safety profile. Ongoing post-marketing surveillance.

Lab Monitoring

Renal function tests (for impaired patients)
Liver function tests (if signs of hepatotoxicity)
INR (if co-administered with warfarin)

Doctor Notes

Counsel patients on potential severe adverse reactions (tendon rupture, neuropathy) and to discontinue immediately if symptoms occur.
Consider culture and susceptibility testing to guide therapy.

Patient Guidelines

Complete the full course of treatment even if you feel better.
Avoid excessive sun exposure due to photosensitivity.
Stay well-hydrated.
Report any joint pain, swelling, or numbness immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose.